Article: Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.

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Title	Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
Authors	Khoo, US1 Chan, KY1 Chan, VS1 Ching, JC1 Yam, L1 Chu, CM1 Lai, ST1 Wong, TY1 Tam, P1 Yip, SP1 Leung, GM1 Lin, CL1 Peiris, JS1
Issue Date	2008
Publisher	Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation	Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2008, v. 14 Suppl 4, p. 31-35 [How to Cite?]
Abstract	1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.
Description	Research Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)
ISSN	1024-2708 2011 SCImago Journal Rankings: 0.054

DC Field	Value
dc.contributor.author	Khoo, US
dc.contributor.author	Chan, KY
dc.contributor.author	Chan, VS
dc.contributor.author	Ching, JC
dc.contributor.author	Yam, L
dc.contributor.author	Chu, CM
dc.contributor.author	Lai, ST
dc.contributor.author	Wong, TY
dc.contributor.author	Tam, P
dc.contributor.author	Yip, SP
dc.contributor.author	Leung, GM
dc.contributor.author	Lin, CL
dc.contributor.author	Peiris, JS
dc.date.accessioned	2010-04-12T01:34:18Z
dc.date.available	2010-04-12T01:34:18Z
dc.date.issued	2008
dc.description.abstract	1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.
dc.description.nature	published_or_final_version
dc.description	Research Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)
dc.identifier.citation	Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2008, v. 14 Suppl 4, p. 31-35 [How to Cite?]
dc.identifier.epage	35
dc.identifier.hkuros	150914
dc.identifier.issn	1024-2708 2011 SCImago Journal Rankings: 0.054
dc.identifier.openurl
dc.identifier.pmid	18708672
dc.identifier.scopus	eid_2-s2.0-70449903273
dc.identifier.spage	31
dc.identifier.uri	http://hdl.handle.net/10722/57361
dc.identifier.volume	14 Suppl 4
dc.language	eng
dc.publisher	Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
dc.publisher.place	Hong Kong
dc.relation.ispartof	Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine
dc.rights	Hong Kong Medical Journal. Copyright © Hong Kong Medical Association.
dc.rights	Creative Commons: Attribution 3.0 Hong Kong License
dc.subject.mesh	Adult
dc.subject.mesh	Alleles
dc.subject.mesh	Analysis of Variance
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	Cell Adhesion Molecules - genetics
dc.subject.mesh	Communicable Diseases - genetics - physiopathology
dc.subject.mesh	Confidence Intervals
dc.subject.mesh	Cytokines - genetics - metabolism
dc.subject.mesh	Female
dc.subject.mesh	Gene Frequency
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	Humans
dc.subject.mesh	Lectins, C-Type - genetics
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Odds Ratio
dc.subject.mesh	Polymorphism, Genetic
dc.subject.mesh	Probability
dc.subject.mesh	Receptors, Cell Surface - genetics
dc.subject.mesh	SARS Virus - genetics - metabolism
dc.subject.mesh	Severe Acute Respiratory Syndrome - genetics - physiopathology
dc.subject.mesh	Tandem Repeat Sequences
dc.subject.mesh	Tumor Necrosis Factor-alpha - genetics - metabolism
dc.title	Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
dc.type	Article

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Author Affiliations

The University of Hong Kong Li Ka Shing Faculty of Medicine