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Article: Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.

TitleRole of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
Authors
Issue Date2008
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal, 2008, v. 14 suppl. 4, p. 31-35 How to Cite?
Abstract1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.
DescriptionResearch Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)
Persistent Identifierhttp://hdl.handle.net/10722/57361
ISSN
2014 Impact Factor: 0.872
2014 SCImago Journal Rankings: 0.237

 

DC FieldValueLanguage
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorChan, KYen_HK
dc.contributor.authorChan, VSen_HK
dc.contributor.authorChing, JCen_HK
dc.contributor.authorYam, Len_HK
dc.contributor.authorChu, CMen_HK
dc.contributor.authorLai, STen_HK
dc.contributor.authorWong, TYen_HK
dc.contributor.authorTam, Pen_HK
dc.contributor.authorYip, SPen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorLin, CLen_HK
dc.contributor.authorPeiris, JSen_HK
dc.date.accessioned2010-04-12T01:34:18Z-
dc.date.available2010-04-12T01:34:18Z-
dc.date.issued2008en_HK
dc.identifier.citationHong Kong Medical Journal, 2008, v. 14 suppl. 4, p. 31-35en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57361-
dc.descriptionResearch Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)en_HK
dc.description.abstract1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong Medical Journalen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdulten_HK
dc.subject.meshAllelesen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshCell Adhesion Molecules - geneticsen_HK
dc.subject.meshCommunicable Diseases - genetics - physiopathologyen_HK
dc.subject.meshConfidence Intervalsen_HK
dc.subject.meshCytokines - genetics - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLectins, C-Type - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshProbabilityen_HK
dc.subject.meshReceptors, Cell Surface - geneticsen_HK
dc.subject.meshSARS Virus - genetics - metabolismen_HK
dc.subject.meshSevere Acute Respiratory Syndrome - genetics - physiopathologyen_HK
dc.subject.meshTandem Repeat Sequencesen_HK
dc.subject.meshTumor Necrosis Factor-alpha - genetics - metabolismen_HK
dc.titleRole of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=14&issue=4 Suppl 4&spage=S31&epage=S35&date=2008&atitle=Role+of+polymorphisms+of+the+inflammatory+response+genes+and+DC-SIGNR+in+genetic+susceptibility+to+SARS+and+other+infectionsen_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.emailChan, KY: kelvinc@pathology.hku.hken_HK
dc.identifier.emailChan, VS: sfvchan@hku.hken_HK
dc.identifier.emailTam, P: paultam@hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.emailPeiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityChan, KY=rp00453en_HK
dc.identifier.authorityChan, VS=rp01459en_HK
dc.identifier.authorityTam, P=rp00060en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityPeiris, JS=rp00410en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid18708672en_HK
dc.identifier.scopuseid_2-s2.0-70449903273en_HK
dc.identifier.hkuros150914-
dc.identifier.volume14en_HK
dc.identifier.issuesuppl. 4-
dc.identifier.spage31en_HK
dc.identifier.epage35en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridChan, KY=7406034195en_HK
dc.identifier.scopusauthoridChan, VS=35200370000en_HK
dc.identifier.scopusauthoridChing, JC=15735635300en_HK
dc.identifier.scopusauthoridYam, L=7102764741en_HK
dc.identifier.scopusauthoridChu, CM=7404345558en_HK
dc.identifier.scopusauthoridLai, ST=7402937038en_HK
dc.identifier.scopusauthoridWong, TY=55350855600en_HK
dc.identifier.scopusauthoridTam, P=7202539421en_HK
dc.identifier.scopusauthoridYip, SP=7102133673en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridLin, CL=37099293900en_HK
dc.identifier.scopusauthoridPeiris, JS=7005486823en_HK

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