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Article: Salvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat

TitleSalvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the rat
Authors
Keywords15-F 2t-isoprostane
Myocardial ischemia reperfusion
Salvia miltiorrhiza
Issue Date2007
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
Citation
Canadian Journal Of Physiology And Pharmacology, 2007, v. 85 n. 10, p. 1012-1019 How to Cite?
AbstractOxidative stress may play a causative role in myocardial ischemia-reperfusion injury. However, it is a relatively understudied aspect regarding an optimal timing of antioxidant intervention during ischemia-reperfusion. The present study investigates the effect of different treatment regimens of Salvia miltiorrhiza (SM) herb extracts containing phenolic compounds that possess potent antioxidant properties on postischemic myocardial functional recovery in the setting of global myocardial ischemia and reperfusion. Langendorff-perfused rat hearts were subjected to 40 min of global ischemia at 37°C followed by 60 min of reperfusion, and were randomly assigned into the untreated control and 2 SM-treated groups (n = 7 per group). In treatment 1 (SM1), 3 mg/mL of water soluble extract of SM was given for 10 min before ischemia and continued during ischemia through the aorta at a reduced flow rate of 60 μL/min, but not during reperfusion. In treatment 2 (SM2), SM (3 mg/mL) was given during the first 15 min of reperfusion. During ischemia, hearts in the control and SM2 groups were given physiological saline at 60 μL/min. The SM1 treatment reduced the production of 15-F2t- isoprostane, a specific index of oxidative stress-induced lipid peroxidation, during ischemia (94 ± 20, 43 ± 6, and 95 ± 15 pg/mL in the coronary effluent in control, SM1, and SM2 groups, respectively; p < 0.05, SM1 vs. control or SM2) and post-poned the onset of ischemic contracture. However, SM2, but not the SM1 regimen, significantly reduced 15-F 2t-isoprostane production during early reperfusion and led to optimal postischemic myocardial functional recovery (left ventricular developed pressure 51 ± 4, 46 ± 4, and 60 ± 6 mmHg in the control, SM1, and SM2 groups, respectively, at 60 min of reperfusion; p < 0.05, SM2 vs. control or SM1) and reduced myocardial infarct size as measured by triphenyltetrazolium chloride staining (26% ± 2%, 22% ± 2%, and 20% ± 2% of the total area in the control, SM1, and SM2 groups, respectively, p < 0.05, SM2 vs. control). It is concluded that S. miltiorrhiza could be beneficial in the treatment of myocardial ischemic injury and the timing of administration seems important. © 2007 NRC.
Persistent Identifierhttp://hdl.handle.net/10722/57357
ISSN
2015 Impact Factor: 1.704
2015 SCImago Journal Rankings: 0.683
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNie, Ren_HK
dc.contributor.authorXia, Ren_HK
dc.contributor.authorZhong, Xen_HK
dc.contributor.authorXia, Zen_HK
dc.date.accessioned2010-04-12T01:34:08Z-
dc.date.available2010-04-12T01:34:08Z-
dc.date.issued2007en_HK
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology, 2007, v. 85 n. 10, p. 1012-1019en_HK
dc.identifier.issn0008-4212en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57357-
dc.description.abstractOxidative stress may play a causative role in myocardial ischemia-reperfusion injury. However, it is a relatively understudied aspect regarding an optimal timing of antioxidant intervention during ischemia-reperfusion. The present study investigates the effect of different treatment regimens of Salvia miltiorrhiza (SM) herb extracts containing phenolic compounds that possess potent antioxidant properties on postischemic myocardial functional recovery in the setting of global myocardial ischemia and reperfusion. Langendorff-perfused rat hearts were subjected to 40 min of global ischemia at 37°C followed by 60 min of reperfusion, and were randomly assigned into the untreated control and 2 SM-treated groups (n = 7 per group). In treatment 1 (SM1), 3 mg/mL of water soluble extract of SM was given for 10 min before ischemia and continued during ischemia through the aorta at a reduced flow rate of 60 μL/min, but not during reperfusion. In treatment 2 (SM2), SM (3 mg/mL) was given during the first 15 min of reperfusion. During ischemia, hearts in the control and SM2 groups were given physiological saline at 60 μL/min. The SM1 treatment reduced the production of 15-F2t- isoprostane, a specific index of oxidative stress-induced lipid peroxidation, during ischemia (94 ± 20, 43 ± 6, and 95 ± 15 pg/mL in the coronary effluent in control, SM1, and SM2 groups, respectively; p < 0.05, SM1 vs. control or SM2) and post-poned the onset of ischemic contracture. However, SM2, but not the SM1 regimen, significantly reduced 15-F 2t-isoprostane production during early reperfusion and led to optimal postischemic myocardial functional recovery (left ventricular developed pressure 51 ± 4, 46 ± 4, and 60 ± 6 mmHg in the control, SM1, and SM2 groups, respectively, at 60 min of reperfusion; p < 0.05, SM2 vs. control or SM1) and reduced myocardial infarct size as measured by triphenyltetrazolium chloride staining (26% ± 2%, 22% ± 2%, and 20% ± 2% of the total area in the control, SM1, and SM2 groups, respectively, p < 0.05, SM2 vs. control). It is concluded that S. miltiorrhiza could be beneficial in the treatment of myocardial ischemic injury and the timing of administration seems important. © 2007 NRC.en_HK
dc.languageengen_HK
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjppen_HK
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCanadian Journal of Physiology and Pharmacology. Copyright © N R C Research Press.en_HK
dc.rightsPublisher PDF may be archived 6 months after publicationen_HK
dc.subject15-F 2t-isoprostaneen_HK
dc.subjectMyocardial ischemia reperfusionen_HK
dc.subjectSalvia miltiorrhizaen_HK
dc.subject.meshAntioxidants - administration & dosage - pharmacology - therapeutic useen_HK
dc.subject.meshDrugs, Chinese Herbal - administration & dosage - pharmacology - therapeutic useen_HK
dc.subject.meshMyocardial Infarction - metabolism - pathology - physiopathology - prevention & controlen_HK
dc.subject.meshMyocardial Reperfusion Injury - drug therapy - metabolism - pathology - physiopathologyen_HK
dc.subject.meshMyocardium - metabolism - pathologyen_HK
dc.titleSalvia miltiorrhiza treatment during early reperfusion reduced postischemic myocardial injury in the raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-4212&volume=85&issue=10&spage=1012&epage=1019&date=2007&atitle=Salvia+miltiorrhiza+treatment+during+early+reperfusion+reduced+postischemic+myocardial+injury+in+the+raten_HK
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_HK
dc.identifier.authorityXia, Z=rp00532en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1139/Y07-092en_HK
dc.identifier.pmid18066102-
dc.identifier.scopuseid_2-s2.0-38049045493en_HK
dc.identifier.hkuros140044-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38049045493&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1012en_HK
dc.identifier.epage1019en_HK
dc.identifier.isiWOS:000251508000005-
dc.publisher.placeCanadaen_HK

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