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Article: The antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice

TitleThe antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db mice
Authors
Keywordsdb/db mice
Diabetes
Traditional Chinese medicine (TCM)
Issue Date2008
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=8
Citation
Biologics: Targets And Therapy, 2008, v. 2 n. 3, p. 571-576 How to Cite?
AbstractWe evaluated the antidiabetic effects of a mixed vegetable powder-formula I (MVP-FI), which is a dry powder mixture of over 65 kinds of vegetables and fruits, using the db/db type 2 diabetes mouse model. The db/db mice at 8-10 weeks of age were randomly divided into three groups: vehicle treatment, 1.575 g/kg MVP-FI treatment, and 3.15 g/kg MVP-FI treatment. During 12 days of treatment, we measured food intake and body weight changes, fasting blood glucose levels, and plasma lipid levels. Our results showed that the food intake and the body weight of MVP-FI-treated group were decreased gradually. Moreover, the fasting blood glucose level of the treated group was significantly dropped to a normal level comparable to that of the lean mice. Furthermore, we also found that the plasma triglyceride level in the treated group was dropped, whereas the high-density lipoprotein (HDL) level was increased and total cholesterol/HDL-cholesterol ratio was decreased. Taken together, these results suggest that the diabetic conditions of the db/db mice have been improved after 12 days treatment with MVP-FI. The antihyperglycemic and antiobese activities of the MVP-FI, as demonstrated in the present study, may have important clinical implications for improving the management of type 2 diabetic patients. © 2008 Yeung et al, publisher and licensee Dove Medical Press Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/57174
ISSN
2015 SCImago Journal Rankings: 1.046
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, CMen_HK
dc.contributor.authorTan, Yen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorKo, KHen_HK
dc.contributor.authorYang, PHen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorLin, MCen_HK
dc.date.accessioned2010-04-12T01:28:17Z-
dc.date.available2010-04-12T01:28:17Z-
dc.date.issued2008en_HK
dc.identifier.citationBiologics: Targets And Therapy, 2008, v. 2 n. 3, p. 571-576en_HK
dc.identifier.issn1177-5475en_HK
dc.identifier.urihttp://hdl.handle.net/10722/57174-
dc.description.abstractWe evaluated the antidiabetic effects of a mixed vegetable powder-formula I (MVP-FI), which is a dry powder mixture of over 65 kinds of vegetables and fruits, using the db/db type 2 diabetes mouse model. The db/db mice at 8-10 weeks of age were randomly divided into three groups: vehicle treatment, 1.575 g/kg MVP-FI treatment, and 3.15 g/kg MVP-FI treatment. During 12 days of treatment, we measured food intake and body weight changes, fasting blood glucose levels, and plasma lipid levels. Our results showed that the food intake and the body weight of MVP-FI-treated group were decreased gradually. Moreover, the fasting blood glucose level of the treated group was significantly dropped to a normal level comparable to that of the lean mice. Furthermore, we also found that the plasma triglyceride level in the treated group was dropped, whereas the high-density lipoprotein (HDL) level was increased and total cholesterol/HDL-cholesterol ratio was decreased. Taken together, these results suggest that the diabetic conditions of the db/db mice have been improved after 12 days treatment with MVP-FI. The antihyperglycemic and antiobese activities of the MVP-FI, as demonstrated in the present study, may have important clinical implications for improving the management of type 2 diabetic patients. © 2008 Yeung et al, publisher and licensee Dove Medical Press Ltd.en_HK
dc.languageengen_HK
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/articles.php?journal_id=8en_HK
dc.relation.ispartofBiologics: Targets and Therapyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectdb/db miceen_HK
dc.subjectDiabetesen_HK
dc.subjectTraditional Chinese medicine (TCM)en_HK
dc.titleThe antidiabetic effects of a dry powder of dietary vegetable and fruit mixtures in diabetic db/db miceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1177-5475&volume=2&issue=3&spage=571&epage=576&date=2008&atitle=The+antidiabetic+effects+of+a+dry+powder+of+dietary+vegetable+and+fruit+mixtures+in+diabetic+db/db+miceen_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid19707387-
dc.identifier.pmcidPMC2721366-
dc.identifier.scopuseid_2-s2.0-83455211823en_HK
dc.identifier.hkuros145155-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83455211823&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue3en_HK
dc.identifier.spage571en_HK
dc.identifier.epage576en_HK
dc.publisher.placeNew Zealanden_HK
dc.identifier.scopusauthoridYeung, CM=7201354151en_HK
dc.identifier.scopusauthoridTan, Y=54685062200en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridLu, L=7403963552en_HK
dc.identifier.scopusauthoridKo, KH=7202688627en_HK
dc.identifier.scopusauthoridYang, PH=24340289000en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridLin, MC=7404816359en_HK

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