Article: Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance

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TitleHaplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
AuthorsOng, KL1
Wong, LYF1
Man, YB1
Leung, RYH1
Song, YQ1
Lam, KSL1
Cheung, BMY1
KeywordsHaplotype
Hypertension
Insulin resistance
Metabolic syndrome
Single nucleotide polymorphism
Urotensin II
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
CitationPeptides, 2006, v. 27 n. 7, p. 1659-1667 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.peptides.2006.02.008
AbstractWe studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved.
ISSN0196-9781
2011 Impact Factor: 2.434
2011 SCImago Journal Rankings: 0.180
DOIhttp://dx.doi.org/10.1016/j.peptides.2006.02.008
ISI Accession Number IDWOS:000238780300010
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorOng, KL
dc.contributor.authorWong, LYF
dc.contributor.authorMan, YB
dc.contributor.authorLeung, RYH
dc.contributor.authorSong, YQ
dc.contributor.authorLam, KSL
dc.contributor.authorCheung, BMY
dc.date.accessioned2009-04-03T07:40:53Z
dc.date.available2009-04-03T07:40:53Z
dc.date.issued2006
dc.description.abstractWe studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved.
dc.description.naturepostprint
dc.identifier.citationPeptides, 2006, v. 27 n. 7, p. 1659-1667 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.peptides.2006.02.008
dc.identifier.doihttp://dx.doi.org/10.1016/j.peptides.2006.02.008
dc.identifier.epage1667
dc.identifier.hkuros119732
dc.identifier.isiWOS:000238780300010
dc.identifier.issn0196-9781
2011 Impact Factor: 2.434
2011 SCImago Journal Rankings: 0.180
dc.identifier.issue7
dc.identifier.openurl
dc.identifier.pmid16597476
dc.identifier.scopuseid_2-s2.0-33745070225
dc.identifier.spage1659
dc.identifier.urihttp://hdl.handle.net/10722/54243
dc.identifier.volume27
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
dc.publisher.placeUnited States
dc.relation.ispartofPeptides
dc.relation.referencesReferences in Scopus
dc.rightsPeptides. Copyright © Elsevier BV.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshHaplotypes
dc.subject.meshInsulin Resistance
dc.subject.meshUrotensins - genetics - metabolism
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshHypertension - blood - genetics
dc.subjectHaplotype
dc.subjectHypertension
dc.subjectInsulin resistance
dc.subjectMetabolic syndrome
dc.subjectSingle nucleotide polymorphism
dc.subjectUrotensin II
dc.titleHaplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong