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Article: Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance

TitleHaplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
Authors
KeywordsHaplotype
Hypertension
Insulin resistance
Metabolic syndrome
Single nucleotide polymorphism
Urotensin II
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
Citation
Peptides, 2006, v. 27 n. 7, p. 1659-1667 How to Cite?
AbstractWe studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/54243
ISSN
2014 Impact Factor: 2.618
2013 SCImago Journal Rankings: 0.971
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_HK
dc.contributor.authorWong, LYFen_HK
dc.contributor.authorMan, YBen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2009-04-03T07:40:53Z-
dc.date.available2009-04-03T07:40:53Z-
dc.date.issued2006en_HK
dc.identifier.citationPeptides, 2006, v. 27 n. 7, p. 1659-1667en_HK
dc.identifier.issn0196-9781en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54243-
dc.description.abstractWe studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptidesen_HK
dc.relation.ispartofPeptidesen_HK
dc.rightsPeptides. Copyright © Elsevier BV.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectHaplotypeen_HK
dc.subjectHypertensionen_HK
dc.subjectInsulin resistanceen_HK
dc.subjectMetabolic syndromeen_HK
dc.subjectSingle nucleotide polymorphismen_HK
dc.subjectUrotensin IIen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshInsulin Resistanceen_HK
dc.subject.meshUrotensins - genetics - metabolismen_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshHypertension - blood - geneticsen_HK
dc.titleHaplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose toleranceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0079-0753&volume=27&issue=7&spage=1659&epage=1667&date=2006&atitle=Haplotypes+in+the+urotensin+II+gene+and+urotensin+II+receptor+gene+are+associated+with+insulin+resistance+and+impaired+glucose+toleranceen_HK
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1016/j.peptides.2006.02.008en_HK
dc.identifier.pmid16597476en_HK
dc.identifier.scopuseid_2-s2.0-33745070225en_HK
dc.identifier.hkuros119732-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745070225&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1659en_HK
dc.identifier.epage1667en_HK
dc.identifier.isiWOS:000238780300010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK
dc.identifier.scopusauthoridMan, YB=10245005900en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK

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