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Article: Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
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TitleHaplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
 
AuthorsOng, KL1
Wong, LYF1
Man, YB1
Leung, RYH1
Song, YQ1
Lam, KSL1
Cheung, BMY1
 
KeywordsHaplotype
Hypertension
Insulin resistance
Metabolic syndrome
Single nucleotide polymorphism
Urotensin II
 
Issue Date2006
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
 
CitationPeptides, 2006, v. 27 n. 7, p. 1659-1667 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.peptides.2006.02.008
 
AbstractWe studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved.
 
ISSN0196-9781
2013 Impact Factor: 2.614
2013 SCImago Journal Rankings: 0.971
 
DOIhttp://dx.doi.org/10.1016/j.peptides.2006.02.008
 
ISI Accession Number IDWOS:000238780300010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorWong, LYF
 
dc.contributor.authorMan, YB
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorSong, YQ
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorCheung, BMY
 
dc.date.accessioned2009-04-03T07:40:53Z
 
dc.date.available2009-04-03T07:40:53Z
 
dc.date.issued2006
 
dc.description.abstractWe studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved.
 
dc.description.naturepostprint
 
dc.identifier.citationPeptides, 2006, v. 27 n. 7, p. 1659-1667 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.peptides.2006.02.008
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.peptides.2006.02.008
 
dc.identifier.epage1667
 
dc.identifier.hkuros119732
 
dc.identifier.isiWOS:000238780300010
 
dc.identifier.issn0196-9781
2013 Impact Factor: 2.614
2013 SCImago Journal Rankings: 0.971
 
dc.identifier.issue7
 
dc.identifier.openurl
 
dc.identifier.pmid16597476
 
dc.identifier.scopuseid_2-s2.0-33745070225
 
dc.identifier.spage1659
 
dc.identifier.urihttp://hdl.handle.net/10722/54243
 
dc.identifier.volume27
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides
 
dc.publisher.placeUnited States
 
dc.relation.ispartofPeptides
 
dc.relation.referencesReferences in Scopus
 
dc.rightsPeptides. Copyright © Elsevier BV.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshHaplotypes
 
dc.subject.meshInsulin Resistance
 
dc.subject.meshUrotensins - genetics - metabolism
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshHypertension - blood - genetics
 
dc.subjectHaplotype
 
dc.subjectHypertension
 
dc.subjectInsulin resistance
 
dc.subjectMetabolic syndrome
 
dc.subjectSingle nucleotide polymorphism
 
dc.subjectUrotensin II
 
dc.titleHaplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong