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Article: Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
Title | Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance |
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Authors | |
Keywords | Haplotype Hypertension Insulin resistance Metabolic syndrome Single nucleotide polymorphism Urotensin II |
Issue Date | 2006 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides |
Citation | Peptides, 2006, v. 27 n. 7, p. 1659-1667 How to Cite? |
Abstract | We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/54243 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.826 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Ong, KL | en_HK |
dc.contributor.author | Wong, LYF | en_HK |
dc.contributor.author | Man, YB | en_HK |
dc.contributor.author | Leung, RYH | en_HK |
dc.contributor.author | Song, YQ | en_HK |
dc.contributor.author | Lam, KSL | en_HK |
dc.contributor.author | Cheung, BMY | en_HK |
dc.date.accessioned | 2009-04-03T07:40:53Z | - |
dc.date.available | 2009-04-03T07:40:53Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Peptides, 2006, v. 27 n. 7, p. 1659-1667 | en_HK |
dc.identifier.issn | 0196-9781 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/54243 | - |
dc.description.abstract | We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and β-cell function. For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance. © 2006 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/peptides | en_HK |
dc.relation.ispartof | Peptides | en_HK |
dc.rights | Peptides. Copyright © Elsevier BV. | en_HK |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Haplotype | en_HK |
dc.subject | Hypertension | en_HK |
dc.subject | Insulin resistance | en_HK |
dc.subject | Metabolic syndrome | en_HK |
dc.subject | Single nucleotide polymorphism | en_HK |
dc.subject | Urotensin II | en_HK |
dc.subject.mesh | Haplotypes | en_HK |
dc.subject.mesh | Insulin Resistance | en_HK |
dc.subject.mesh | Urotensins - genetics - metabolism | en_HK |
dc.subject.mesh | Polymorphism, Single Nucleotide | en_HK |
dc.subject.mesh | Hypertension - blood - genetics | en_HK |
dc.title | Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0079-0753&volume=27&issue=7&spage=1659&epage=1667&date=2006&atitle=Haplotypes+in+the+urotensin+II+gene+and+urotensin+II+receptor+gene+are+associated+with+insulin+resistance+and+impaired+glucose+tolerance | en_HK |
dc.identifier.email | Song, YQ:songy@hkucc.hku.hk | en_HK |
dc.identifier.email | Lam, KSL:ksllam@hku.hk | en_HK |
dc.identifier.email | Cheung, BMY:mycheung@hku.hk | en_HK |
dc.identifier.authority | Song, YQ=rp00488 | en_HK |
dc.identifier.authority | Lam, KSL=rp00343 | en_HK |
dc.identifier.authority | Cheung, BMY=rp01321 | en_HK |
dc.description.nature | postprint | en_HK |
dc.identifier.doi | 10.1016/j.peptides.2006.02.008 | en_HK |
dc.identifier.pmid | 16597476 | - |
dc.identifier.scopus | eid_2-s2.0-33745070225 | en_HK |
dc.identifier.hkuros | 119732 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33745070225&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 27 | en_HK |
dc.identifier.issue | 7 | en_HK |
dc.identifier.spage | 1659 | en_HK |
dc.identifier.epage | 1667 | en_HK |
dc.identifier.isi | WOS:000238780300010 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Ong, KL=8340854000 | en_HK |
dc.identifier.scopusauthorid | Wong, LYF=24476809800 | en_HK |
dc.identifier.scopusauthorid | Man, YB=10245005900 | en_HK |
dc.identifier.scopusauthorid | Leung, RYH=7101876102 | en_HK |
dc.identifier.scopusauthorid | Song, YQ=7404921212 | en_HK |
dc.identifier.scopusauthorid | Lam, KSL=8082870600 | en_HK |
dc.identifier.scopusauthorid | Cheung, BMY=7103294806 | en_HK |
dc.identifier.issnl | 0196-9781 | - |