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Article: Human T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1
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TitleHuman T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1
 
AuthorsChin, KT1
Chun, ACS1
Ching, YP1 1
Jeang, KT2
Jin, DY1 1
 
Issue Date2007
 
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
 
CitationCancer Research, 2007, v. 67 n. 3, p. 1072-1081 [How to Cite?]
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-06-3053
 
AbstractHuman T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor coactivator that forms a complex with the glucocorticoid receptor. TAX1BP1 and Tax colocalize into intranuclear speckles that partially overlap with but are not identical to the PML oncogenic domains. Tax binds TAX1BP1 directly, induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the coactivator function of TAX1BP1. Genetic knockout of Tax1bp1 in mice abrogates the influence of Tax on the activation of nuclear receptors. We propose that Tax-TAX1BP1 interaction mechanistically explains the previously reported repression of nuclear receptor activity by Tax. ©2007 American Association for Cancer Research.
 
ISSN0008-5472
2012 Impact Factor: 8.65
2012 SCImago Journal Rankings: 4.152
 
DOIhttp://dx.doi.org/10.1158/0008-5472.CAN-06-3053
 
ISI Accession Number IDWOS:000244137300031
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChin, KT
 
dc.contributor.authorChun, ACS
 
dc.contributor.authorChing, YP
 
dc.contributor.authorJeang, KT
 
dc.contributor.authorJin, DY
 
dc.date.accessioned2009-04-03T07:40:49Z
 
dc.date.available2009-04-03T07:40:49Z
 
dc.date.issued2007
 
dc.description.abstractHuman T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor coactivator that forms a complex with the glucocorticoid receptor. TAX1BP1 and Tax colocalize into intranuclear speckles that partially overlap with but are not identical to the PML oncogenic domains. Tax binds TAX1BP1 directly, induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the coactivator function of TAX1BP1. Genetic knockout of Tax1bp1 in mice abrogates the influence of Tax on the activation of nuclear receptors. We propose that Tax-TAX1BP1 interaction mechanistically explains the previously reported repression of nuclear receptor activity by Tax. ©2007 American Association for Cancer Research.
 
dc.description.naturepostprint
 
dc.identifier.citationCancer Research, 2007, v. 67 n. 3, p. 1072-1081 [How to Cite?]
DOI: http://dx.doi.org/10.1158/0008-5472.CAN-06-3053
 
dc.identifier.doihttp://dx.doi.org/10.1158/0008-5472.CAN-06-3053
 
dc.identifier.epage1081
 
dc.identifier.hkuros126752
 
dc.identifier.isiWOS:000244137300031
 
dc.identifier.issn0008-5472
2012 Impact Factor: 8.65
2012 SCImago Journal Rankings: 4.152
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid17283140
 
dc.identifier.scopuseid_2-s2.0-33847010696
 
dc.identifier.spage1072
 
dc.identifier.urihttp://hdl.handle.net/10722/54241
 
dc.identifier.volume67
 
dc.languageeng
 
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshNeoplasm Proteins - antagonists & inhibitors - metabolism
 
dc.subject.meshCell Nucleus - metabolism
 
dc.subject.meshNeoplasm Proteins - antagonists & inhibitors - metabolism
 
dc.subject.meshReceptors, Cytoplasmic and Nuclear - antagonists & inhibitors - metabolism
 
dc.subject.meshSignal Transduction
 
dc.titleHuman T-cell leukemia virus oncoprotein Tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1
 
dc.typeArticle
 
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<contributor.author>Jin, DY</contributor.author>
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<description.abstract>Human T-cell leukemia virus type 1 oncoprotein Tax is a transcriptional regulator that interacts with a large number of host cell factors. Here, we report the novel characterization of the interaction of Tax with a human cell protein named Tax1-binding protein 1 (TAX1BP1). We show that TAX1BP1 is a nuclear receptor coactivator that forms a complex with the glucocorticoid receptor. TAX1BP1 and Tax colocalize into intranuclear speckles that partially overlap with but are not identical to the PML oncogenic domains. Tax binds TAX1BP1 directly, induces the dissociation of TAX1BP1 from the glucocorticoid receptor-containing protein complex, and represses the coactivator function of TAX1BP1. Genetic knockout of Tax1bp1 in mice abrogates the influence of Tax on the activation of nuclear receptors. We propose that Tax-TAX1BP1 interaction mechanistically explains the previously reported repression of nuclear receptor activity by Tax. &#169;2007 American Association for Cancer Research.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. National Institute of Allergy and Infectious Diseases