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Article: Nano hemostat solution: immediate hemostasis at the nanoscale

TitleNano hemostat solution: immediate hemostasis at the nanoscale
Authors
KeywordsHemostasis
Nanotechnology
Self-assembling peptide
Surgery
Trauma
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
Citation
Nanomedicine: Nanotechnology, Biology, And Medicine, 2006, v. 2 n. 4, p. 207-215 How to Cite?
AbstractHemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, which could fundamentally change how much blood is needed during surgery of the future. © 2006.
Persistent Identifierhttp://hdl.handle.net/10722/54239
ISSN
2015 Impact Factor: 5.671
2015 SCImago Journal Rankings: 1.886
References

 

DC FieldValueLanguage
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorKau, PWFen_HK
dc.contributor.authorSchneider, GEen_HK
dc.contributor.authorZhang, Sen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2009-04-03T07:40:45Z-
dc.date.available2009-04-03T07:40:45Z-
dc.date.issued2006en_HK
dc.identifier.citationNanomedicine: Nanotechnology, Biology, And Medicine, 2006, v. 2 n. 4, p. 207-215en_HK
dc.identifier.issn1549-9634en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54239-
dc.description.abstractHemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, which could fundamentally change how much blood is needed during surgery of the future. © 2006.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomeden_HK
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicineen_HK
dc.rightsNanomedicine: Nanotechnology, Biology and Medicine. Copyright © Elsevier Inc.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectHemostasisen_HK
dc.subjectNanotechnologyen_HK
dc.subjectSelf-assembling peptideen_HK
dc.subjectSurgeryen_HK
dc.subjectTraumaen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBiopsyen_HK
dc.subject.meshBlood Coagulation - drug effectsen_HK
dc.subject.meshBlood Loss, Surgicalen_HK
dc.subject.meshCricetinaeen_HK
dc.subject.meshHemostasis, Surgicalen_HK
dc.subject.meshHemostatic Techniquesen_HK
dc.subject.meshHemostatics - administration & dosage - chemistryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMesocricetusen_HK
dc.subject.meshMiceen_HK
dc.subject.meshNanomedicine - instrumentation - methodsen_HK
dc.subject.meshNanotechnology - instrumentation - methodsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshSkin - pathologyen_HK
dc.titleNano hemostat solution: immediate hemostasis at the nanoscaleen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1549-9634&volume=2&issue=4&spage=207&epage=215&date=2006&atitle=Nano+hemostat+solution:+immediate+hemostasis+at+the+nanoscale+en_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1016/j.nano.2006.08.001en_HK
dc.identifier.pmid17292144-
dc.identifier.scopuseid_2-s2.0-33845287137en_HK
dc.identifier.hkuros124249-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845287137&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume2en_HK
dc.identifier.issue4en_HK
dc.identifier.spage207en_HK
dc.identifier.epage215en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridTay, DKC=55392935900en_HK
dc.identifier.scopusauthoridKau, PWF=15136310300en_HK
dc.identifier.scopusauthoridSchneider, GE=55057824300en_HK
dc.identifier.scopusauthoridZhang, S=7409370463en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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