Article: Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.

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Publisher Website: 10.1007/s11010-006-9304-6
Scopus: eid_2-s2.0-34447542890
PMID: 16964437

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Title	Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.
Authors	Chin, KT1 Xu, HT1 Ching, YP1 Jin, DY1
Issue Date	2007
Publisher	Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation	Molecular And Cellular Biochemistry, 2007, v. 296 n. 1-2, p. 109-119 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11010-006-9304-6
Abstract	We have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.
ISSN	0300-8177 2011 Impact Factor: 2.057 2011 SCImago Journal Rankings: 0.195
DOI	http://dx.doi.org/10.1007/s11010-006-9304-6

DC Field	Value
dc.contributor.author	Chin, KT
dc.contributor.author	Xu, HT
dc.contributor.author	Ching, YP
dc.contributor.author	Jin, DY
dc.date.accessioned	2009-04-03T07:40:42Z
dc.date.available	2009-04-03T07:40:42Z
dc.date.issued	2007
dc.description.abstract	We have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.
dc.description.nature	postprint
dc.identifier.citation	Molecular And Cellular Biochemistry, 2007, v. 296 n. 1-2, p. 109-119 [How to Cite?] DOI: http://dx.doi.org/10.1007/s11010-006-9304-6
dc.identifier.citeulike	1196787
dc.identifier.doi	http://dx.doi.org/10.1007/s11010-006-9304-6
dc.identifier.epage	119
dc.identifier.hkuros	126753
dc.identifier.isi	WOS:000244691900013
dc.identifier.issn	0300-8177 2011 Impact Factor: 2.057 2011 SCImago Journal Rankings: 0.195
dc.identifier.issue	1-2
dc.identifier.pmid	16964437
dc.identifier.scopus	eid_2-s2.0-34447542890
dc.identifier.spage	109
dc.identifier.uri	http://hdl.handle.net/10722/54237
dc.identifier.volume	296
dc.language	eng
dc.publisher	Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
dc.publisher.place	United States
dc.relation.ispartof	Molecular and cellular biochemistry
dc.rights	The original publication is available at www.springerlink.com
dc.rights	Creative Commons: Attribution 3.0 Hong Kong License
dc.subject.mesh	Antibiotics, Antineoplastic - metabolism
dc.subject.mesh	Antigens, Neoplasm - classification - genetics - metabolism
dc.subject.mesh	Carrier Proteins - genetics - metabolism
dc.subject.mesh	Sequence Homology, Amino Acid
dc.subject.mesh	Tissue Distribution
dc.title	Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.
dc.type	Article

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Author Affiliations

The University of Hong Kong