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Article: Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.
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TitleDifferential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.
 
AuthorsChin, KT1
Xu, HT1
Ching, YP1
Jin, DY1
 
Issue Date2007
 
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
 
CitationMolecular And Cellular Biochemistry, 2007, v. 296 n. 1-2, p. 109-119 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11010-006-9304-6
 
AbstractWe have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.
 
ISSN0300-8177
2012 Impact Factor: 2.329
2012 SCImago Journal Rankings: 0.799
 
DOIhttp://dx.doi.org/10.1007/s11010-006-9304-6
 
ISI Accession Number IDWOS:000244691900013
 
DC FieldValue
dc.contributor.authorChin, KT
 
dc.contributor.authorXu, HT
 
dc.contributor.authorChing, YP
 
dc.contributor.authorJin, DY
 
dc.date.accessioned2009-04-03T07:40:42Z
 
dc.date.available2009-04-03T07:40:42Z
 
dc.date.issued2007
 
dc.description.abstractWe have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.
 
dc.description.naturepostprint
 
dc.identifier.citationMolecular And Cellular Biochemistry, 2007, v. 296 n. 1-2, p. 109-119 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s11010-006-9304-6
 
dc.identifier.citeulike1196787
 
dc.identifier.doihttp://dx.doi.org/10.1007/s11010-006-9304-6
 
dc.identifier.epage119
 
dc.identifier.hkuros126753
 
dc.identifier.isiWOS:000244691900013
 
dc.identifier.issn0300-8177
2012 Impact Factor: 2.329
2012 SCImago Journal Rankings: 0.799
 
dc.identifier.issue1-2
 
dc.identifier.pmid16964437
 
dc.identifier.scopuseid_2-s2.0-34447542890
 
dc.identifier.spage109
 
dc.identifier.urihttp://hdl.handle.net/10722/54237
 
dc.identifier.volume296
 
dc.languageeng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMolecular and cellular biochemistry
 
dc.rightsThe original publication is available at www.springerlink.com
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAntibiotics, Antineoplastic - metabolism
 
dc.subject.meshAntigens, Neoplasm - classification - genetics - metabolism
 
dc.subject.meshCarrier Proteins - genetics - metabolism
 
dc.subject.meshSequence Homology, Amino Acid
 
dc.subject.meshTissue Distribution
 
dc.titleDifferential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.
 
dc.typeArticle
 
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<contributor.author>Xu, HT</contributor.author>
<contributor.author>Ching, YP</contributor.author>
<contributor.author>Jin, DY</contributor.author>
<date.accessioned>2009-04-03T07:40:42Z</date.accessioned>
<date.available>2009-04-03T07:40:42Z</date.available>
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<identifier.citation>Molecular And Cellular Biochemistry, 2007, v. 296 n. 1-2, p. 109-119</identifier.citation>
<identifier.issn>0300-8177</identifier.issn>
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<description.abstract>We have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.</description.abstract>
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<subject.mesh>Antibiotics, Antineoplastic - metabolism</subject.mesh>
<subject.mesh>Antigens, Neoplasm - classification - genetics - metabolism</subject.mesh>
<subject.mesh>Carrier Proteins - genetics - metabolism</subject.mesh>
<subject.mesh>Sequence Homology, Amino Acid</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong