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Article: Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.

TitleDifferential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.
Authors
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2007, v. 296 n. 1-2, p. 109-119 How to Cite?
Abstract
We have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.
Persistent Identifierhttp://hdl.handle.net/10722/54237
ISSN
2013 Impact Factor: 2.388
ISI Accession Number ID

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorChin, KTen_HK
dc.contributor.authorXu, HTen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2009-04-03T07:40:42Z-
dc.date.available2009-04-03T07:40:42Z-
dc.date.issued2007en_HK
dc.identifier.citationMolecular And Cellular Biochemistry, 2007, v. 296 n. 1-2, p. 109-119en_HK
dc.identifier.issn0300-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54237-
dc.description.abstractWe have previously identified and characterized human KLHDC2/HCLP-1, a kelch repeat protein that interacts with and inhibits transcription factor LZIP. In this study, we identified and characterized a paralog of KLHDC2 called KLHDC1. KLHDC1 and KLHDC2 share about 50% identity at the level of amino acid sequence and both gene loci localize to human chromosome 14q21.3. This cluster of KLHDC1 and KLHDC2 genes is highly conserved in vertebrates ranging from pufferfish to human. Both genes are expressed highly in skeletal muscle, but weakly in various other tissues. While KLHDC2 was predominantly found in the nucleus, KLHDC1 is a cytoplasmic protein. Neither KLHDC1 nor KLHDC2 binds to actin. In addition, KLHDC1 was unable to inhibit LZIP/CREB3-mediated transcriptional activation. Thus, KLHDC1 and KLHDC2 have differential localization and activity in cultured mammalian cells.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_HK
dc.relation.ispartofMolecular and cellular biochemistryen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntibiotics, Antineoplastic - metabolismen_HK
dc.subject.meshAntigens, Neoplasm - classification - genetics - metabolismen_HK
dc.subject.meshCarrier Proteins - genetics - metabolismen_HK
dc.subject.meshSequence Homology, Amino Aciden_HK
dc.subject.meshTissue Distributionen_HK
dc.titleDifferential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.en_HK
dc.typeArticleen_HK
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1007/s11010-006-9304-6en_HK
dc.identifier.pmid16964437en_HK
dc.identifier.scopuseid_2-s2.0-34447542890en_HK
dc.identifier.hkuros126753-
dc.identifier.volume296en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage109en_HK
dc.identifier.epage119en_HK
dc.identifier.isiWOS:000244691900013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChin, KT=7202995491en_HK
dc.identifier.scopusauthoridXu, HT=16311244600en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.citeulike1196787-

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