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Article: Gene expression patterns in human liver cancers

TitleGene expression patterns in human liver cancers
Authors
Issue Date2002
PublisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/
Citation
Molecular Biology Of The Cell, 2002, v. 13 n. 6, p. 1929-1939 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a leading cause of death worldwide. Using cDNA microarrays to characterize patterns of gene expression in HCC, we found consistent differences between the expression patterns in HCC compared with those seen in nontumor liver tissues. The expression patterns in HCC were also readily distinguished from those associated with tumors metastatic to liver. The global gene expression patterns intrinsic to each tumor were sufficiently distinctive that multiple tumor nodules from the same patient could usually be recognized and distinguished from all the others in the large sample set on the basis of their gene expression patterns alone. The distinctive gene expression patterns are characteristic of the tumors and not the patient; the expression programs seen in clonally independent tumor nodules in the same patient were no more similar than those in tumors from different patients. Moreover, clonally related tumor masses that showed distinct expression profiles were also distinguished by genotypic differences. Some features of the gene expression patterns were associated with specific phenotypic and genotypic characteristics of the tumors, including growth rate, vascular invasion, and p53 over-expression.
Persistent Identifierhttp://hdl.handle.net/10722/54182
ISSN
2015 Impact Factor: 4.037
2015 SCImago Journal Rankings: 3.665
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Xen_HK
dc.contributor.authorCheung, STen_HK
dc.contributor.authorSo, Sen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorBarry, Cen_HK
dc.contributor.authorHiggins, Jen_HK
dc.contributor.authorLai, KMen_HK
dc.contributor.authorJi, Jen_HK
dc.contributor.authorDudoit, Sen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorVan de Rijn, Men_HK
dc.contributor.authorBotstein, Den_HK
dc.contributor.authorBrown, POen_HK
dc.date.accessioned2009-04-03T07:38:56Z-
dc.date.available2009-04-03T07:38:56Z-
dc.date.issued2002en_HK
dc.identifier.citationMolecular Biology Of The Cell, 2002, v. 13 n. 6, p. 1929-1939en_HK
dc.identifier.issn1059-1524en_HK
dc.identifier.urihttp://hdl.handle.net/10722/54182-
dc.description.abstractHepatocellular carcinoma (HCC) is a leading cause of death worldwide. Using cDNA microarrays to characterize patterns of gene expression in HCC, we found consistent differences between the expression patterns in HCC compared with those seen in nontumor liver tissues. The expression patterns in HCC were also readily distinguished from those associated with tumors metastatic to liver. The global gene expression patterns intrinsic to each tumor were sufficiently distinctive that multiple tumor nodules from the same patient could usually be recognized and distinguished from all the others in the large sample set on the basis of their gene expression patterns alone. The distinctive gene expression patterns are characteristic of the tumors and not the patient; the expression programs seen in clonally independent tumor nodules in the same patient were no more similar than those in tumors from different patients. Moreover, clonally related tumor masses that showed distinct expression profiles were also distinguished by genotypic differences. Some features of the gene expression patterns were associated with specific phenotypic and genotypic characteristics of the tumors, including growth rate, vascular invasion, and p53 over-expression.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/en_HK
dc.relation.ispartofMolecular Biology of the Cellen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsMolecular Biology of the Cell. Copyright © American Society for Cell Biology.en_HK
dc.subject.meshCarcinoma, Hepatocellular - epidemiology - genetics - pathologyen_HK
dc.subject.meshGene Expression Regulation, Neoplasticen_HK
dc.subject.meshLiver - physiologyen_HK
dc.subject.meshLiver Neoplasms - epidemiology - genetics - pathologyen_HK
dc.subject.meshRNA, Neoplasm - genetics - isolation & purificationen_HK
dc.titleGene expression patterns in human liver cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1059-1524&volume=13&issue=6&spage=1929&epage=1939&date=2002&atitle=Gene+expression+patterns+in+human+liver+cancersen_HK
dc.identifier.emailCheung, ST: stcheung@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1091/mbc.02-02-0023.en_HK
dc.identifier.pmid12058060en_HK
dc.identifier.pmcidPMC117615-
dc.identifier.scopuseid_2-s2.0-0035985214en_HK
dc.identifier.hkuros69053-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035985214&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1929en_HK
dc.identifier.epage1939en_HK
dc.identifier.isiWOS:000176418800012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, X=8978110800en_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridSo, S=7102397384en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridBarry, C=24167744100en_HK
dc.identifier.scopusauthoridHiggins, J=25642411200en_HK
dc.identifier.scopusauthoridLai, KM=36953971400en_HK
dc.identifier.scopusauthoridJi, J=7201362473en_HK
dc.identifier.scopusauthoridDudoit, S=6602862447en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridVan de Rijn, M=7005571510en_HK
dc.identifier.scopusauthoridBotstein, D=7102711191en_HK
dc.identifier.scopusauthoridBrown, PO=35414776900en_HK

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