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Article: Deletions within the azoospermia factor subregions of the Y chromosome in Hong Kong Chinese men with severe male-factor infertility: controlled clinical study.

TitleDeletions within the azoospermia factor subregions of the Y chromosome in Hong Kong Chinese men with severe male-factor infertility: controlled clinical study.
Authors
Issue Date2000
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2000, v. 6 n. 2, p. 143-146 How to Cite?
AbstractOBJECTIVE: To determine the patterns and the prevalence of microdeletions in the azoospermia factor subregions of the Y chromosome in Hong Kong Chinese men with severe male-factor infertility. DESIGN: Controlled clinical study. SETTING: Reproductive centre of a university teaching hospital, Hong Kong. PARTICIPANTS: Fifty-eight men with severe male-factor infertility who participated in the in vitro fertilisation programme from May 1998 through March 1999, and 46 male volunteers with proven fertility. MAIN OUTCOME MEASURES: Polymerase chain reaction analysis of DNA from peripheral blood lymphocytes using six loci spanning the AZFa, AZFb, and AZFc subregions of the Y chromosome. RESULTS. No microdeletions were detected in the fertile controls or in patients with obstructive azoospermia. Deletions within the AZFc subregion were found in 9% (4/44) of men with non-obstructive azoospermia or severe oligospermia. Neither AZFa nor AZFb deletions were detected in any participants. CONCLUSION: Deletions within the azoospermia factor subregions of the Y chromosome are associated with severe male-factor infertility in Hong Kong Chinese men.
Persistent Identifierhttp://hdl.handle.net/10722/53571
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorTse, JYen_HK
dc.contributor.authorYeung, WSen_HK
dc.contributor.authorLau, EYen_HK
dc.contributor.authorNg, EHen_HK
dc.contributor.authorSo, WWen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2009-04-03T07:23:28Z-
dc.date.available2009-04-03T07:23:28Z-
dc.date.issued2000en_HK
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2000, v. 6 n. 2, p. 143-146en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53571-
dc.description.abstractOBJECTIVE: To determine the patterns and the prevalence of microdeletions in the azoospermia factor subregions of the Y chromosome in Hong Kong Chinese men with severe male-factor infertility. DESIGN: Controlled clinical study. SETTING: Reproductive centre of a university teaching hospital, Hong Kong. PARTICIPANTS: Fifty-eight men with severe male-factor infertility who participated in the in vitro fertilisation programme from May 1998 through March 1999, and 46 male volunteers with proven fertility. MAIN OUTCOME MEASURES: Polymerase chain reaction analysis of DNA from peripheral blood lymphocytes using six loci spanning the AZFa, AZFb, and AZFc subregions of the Y chromosome. RESULTS. No microdeletions were detected in the fertile controls or in patients with obstructive azoospermia. Deletions within the AZFc subregion were found in 9% (4/44) of men with non-obstructive azoospermia or severe oligospermia. Neither AZFa nor AZFb deletions were detected in any participants. CONCLUSION: Deletions within the azoospermia factor subregions of the Y chromosome are associated with severe male-factor infertility in Hong Kong Chinese men.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshChromosome Deletionen_HK
dc.subject.meshInfertility, Male - geneticsen_HK
dc.subject.meshOligospermia - geneticsen_HK
dc.subject.meshY Chromosomeen_HK
dc.subject.meshSperm Injections, Intracytoplasmicen_HK
dc.titleDeletions within the azoospermia factor subregions of the Y chromosome in Hong Kong Chinese men with severe male-factor infertility: controlled clinical study.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=6&issue=2&spage=143&epage=146&date=2000&atitle=Deletions+within+the+azoospermia+factor+subregions+of+the+Y+chromosome+in+Hong+Kong+Chinese+men+with+severe+male-factor+infertility:+controlled+clinical+studyen_HK
dc.identifier.emailYeung, WS:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailNg, EH:nghye@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityYeung, WS=rp00331en_HK
dc.identifier.authorityNg, EH=rp00426en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid10895135-
dc.identifier.scopuseid_2-s2.0-0034203806en_HK
dc.identifier.hkuros50079-
dc.identifier.volume6en_HK
dc.identifier.issue2en_HK
dc.identifier.spage143en_HK
dc.identifier.epage146en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridTse, JY=7102607314en_HK
dc.identifier.scopusauthoridYeung, WS=7102370745en_HK
dc.identifier.scopusauthoridLau, EY=7103086093en_HK
dc.identifier.scopusauthoridNg, EH=35238184300en_HK
dc.identifier.scopusauthoridSo, WW=7004974015en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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