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Article: The natural history of chronic hepatitis B infection

TitleThe natural history of chronic hepatitis B infection
Authors
KeywordsHepatitis B virus
Carcinoma, hepatocellular
Hapatitis, chronic active
Hepatitis, viral, human
Immune tolerance
Issue Date1997
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org
Citation
Hong Kong Medical Journal, 1997, v. 3 n. 3, p. 283-288 How to Cite?
AbstractChronic hepatitis B infection is a global health problem that affects about 300 million people. Of these, 75% are Chinese. Most Chinese who become chronic carriers, contract the virus during the perinatal period. The natural history of these chronic hepatitis B carriers includes an initial immune tolerance phase, followed by immune clearance and an inactive hepatitis B non-replicative phase with the development of cirrhosis that may be complicated by hepatocellular carcinoma. The classification of hepato-cellular carcinoma has recently been revised. Based on immunohistochemical studies, it has been found that patients with hepatocellular carcinoma and biliary markers have a poorer survival than patients with hepatocellular carcinoma but who have negative biliary markers. Sometimes, a fourth phase, a hepatitis B envelope-negative hepatitis B virus replicative phase, reflecting the emergence of a pre-core mutant strain, may follow. Our improved understanding of the natural history of chronic hepatitis B infection has led to more effective approaches towards the control of this viral infection and its sequelae. Most importantly, immunisation against hepatitis B virus in the perinatal setting has been shown to prevent chronic infection.
Persistent Identifierhttp://hdl.handle.net/10722/53406
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorWu, PCen_HK
dc.date.accessioned2009-04-03T07:18:57Z-
dc.date.available2009-04-03T07:18:57Z-
dc.date.issued1997en_HK
dc.identifier.citationHong Kong Medical Journal, 1997, v. 3 n. 3, p. 283-288en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53406-
dc.description.abstractChronic hepatitis B infection is a global health problem that affects about 300 million people. Of these, 75% are Chinese. Most Chinese who become chronic carriers, contract the virus during the perinatal period. The natural history of these chronic hepatitis B carriers includes an initial immune tolerance phase, followed by immune clearance and an inactive hepatitis B non-replicative phase with the development of cirrhosis that may be complicated by hepatocellular carcinoma. The classification of hepato-cellular carcinoma has recently been revised. Based on immunohistochemical studies, it has been found that patients with hepatocellular carcinoma and biliary markers have a poorer survival than patients with hepatocellular carcinoma but who have negative biliary markers. Sometimes, a fourth phase, a hepatitis B envelope-negative hepatitis B virus replicative phase, reflecting the emergence of a pre-core mutant strain, may follow. Our improved understanding of the natural history of chronic hepatitis B infection has led to more effective approaches towards the control of this viral infection and its sequelae. Most importantly, immunisation against hepatitis B virus in the perinatal setting has been shown to prevent chronic infection.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.orgen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.subjectHepatitis B virusen_HK
dc.subjectCarcinoma, hepatocellularen_HK
dc.subjectHapatitis, chronic activeen_HK
dc.subjectHepatitis, viral, humanen_HK
dc.subjectImmune toleranceen_HK
dc.titleThe natural history of chronic hepatitis B infectionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=3&issue=3&spage=283&epage=288&date=1997&atitle=The+natural+history+of+chronic+hepatitis+B+infectionen_HK
dc.identifier.emailLau, GKK: gkklau@netvigator.comen_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid11847373en_HK
dc.identifier.hkuros37181-

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