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Article: The pathology of bone marrow transplantation in Hong Kong Chinese

TitleThe pathology of bone marrow transplantation in Hong Kong Chinese
Authors
KeywordsBone marrow transplantation
Pathology
Graft vs host disease
Opportunistic infections
Immunosuppression
Issue Date1996
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org
Citation
Hong Kong Medical Journal, 1996, v. 2 n. 2, p. 133-137 How to Cite?
AbstractThe pathological lesions found in 68 successfully engrafted patients with human leucocyte antigen-matched sibling-related bone marrow transplants werereviewed retrospectively. Twenty-six (38%) patients had acute graft-versus-host disease, which was slightly less than that reported in Caucasians. Skin was a constant site of involvement (100%), followed by the gastrointestinal tract (74%) and liver (59%). There was a 74% correlation between the clinical and histological grading of cutaneous graft-versus-host disease, while that of the gastrointestinal tract was lower at 60%. Cytomegalovirus colitis was found on histological examination of two patients clinically thought to have graft-versus-host disease. Histological evidence of infection, which included viral hepatitis (n=5), disseminated cytomegalovirus infection (n=3), disseminated aspergillosis (n=2), systemic candidiasis (n=2), Pneumocystis carinii pneumonia (n=1), and bacterial pneumonia (n=1), was present in 14 patients. In addition to graft-versus-host disease and infections, there was a case of veno-occlusive disease of the liver. Histological examination is important in distinguishing graft-versus-host disease from infection and other complications in bone marrow transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/53404
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorShek, TWHen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorChiu, EKWen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2009-04-03T07:18:54Z-
dc.date.available2009-04-03T07:18:54Z-
dc.date.issued1996en_HK
dc.identifier.citationHong Kong Medical Journal, 1996, v. 2 n. 2, p. 133-137en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53404-
dc.description.abstractThe pathological lesions found in 68 successfully engrafted patients with human leucocyte antigen-matched sibling-related bone marrow transplants werereviewed retrospectively. Twenty-six (38%) patients had acute graft-versus-host disease, which was slightly less than that reported in Caucasians. Skin was a constant site of involvement (100%), followed by the gastrointestinal tract (74%) and liver (59%). There was a 74% correlation between the clinical and histological grading of cutaneous graft-versus-host disease, while that of the gastrointestinal tract was lower at 60%. Cytomegalovirus colitis was found on histological examination of two patients clinically thought to have graft-versus-host disease. Histological evidence of infection, which included viral hepatitis (n=5), disseminated cytomegalovirus infection (n=3), disseminated aspergillosis (n=2), systemic candidiasis (n=2), Pneumocystis carinii pneumonia (n=1), and bacterial pneumonia (n=1), was present in 14 patients. In addition to graft-versus-host disease and infections, there was a case of veno-occlusive disease of the liver. Histological examination is important in distinguishing graft-versus-host disease from infection and other complications in bone marrow transplantation.en_HK
dc.languageengen_HK
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.orgen_HK
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Medical Association.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBone marrow transplantationen_HK
dc.subjectPathologyen_HK
dc.subjectGraft vs host diseaseen_HK
dc.subjectOpportunistic infectionsen_HK
dc.subjectImmunosuppressionen_HK
dc.titleThe pathology of bone marrow transplantation in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=2&issue=2&spage=133&epage=137&date=1996&atitle=The+pathology+of+bone+marrow+transplantation+in+Hong+Kong+Chineseen_HK
dc.identifier.emailShek, TWH: whshek@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailChiu, EKW: ekwchiu@HKUCC.hku.hken_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.hkuros25912-

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