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Article: Runx2 regulates endochondral ossification in condyle during mandibular advancement

TitleRunx2 regulates endochondral ossification in condyle during mandibular advancement
Authors
KeywordsChondrocyte
Mandibular condyle
Mechanical stress
Osteoblast
Runx2
Issue Date2005
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2005, v. 84 n. 2, p. 166-171 How to Cite?
AbstractRunx2 is a transcription factor prerequisite for chondrocyte maturation and osteoblast differentiation. We tested the hypothesis that Runx2 is responsible for signaling chondrocyte maturation and endochondral ossification in the condyle during mandibular advancement. Fifty 35-day-old Sprague-Dawley rats were fitted with functional appliances for 3, 7, 14, 21, and 30 days. Experimental animals with 50 matched controls were labeled with bromodeoxyuridine for evaluation of the invasion of chondroclasts and osteoblasts into condylar cartilage. Mandibular advancement elicited Runx2 expression in condylar cartilage, and subsequently led to an expansion of type X collagen domain in the hypertrophic layer. Stronger Runx2 mRNA signals in subchondral bone corresponded with the increase in the recruitment of osteoblasts and chondroclasts, which preceded the increase of new bone formation in the condyle. Thus, Runx2 mediates chondrocyte terminal maturation and endochondral ossification in the mandibular condyle in response to mandibular advancement.
Persistent Identifierhttp://hdl.handle.net/10722/53209
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, GHen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2009-04-03T07:04:12Z-
dc.date.available2009-04-03T07:04:12Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Dental Research, 2005, v. 84 n. 2, p. 166-171en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/53209-
dc.description.abstractRunx2 is a transcription factor prerequisite for chondrocyte maturation and osteoblast differentiation. We tested the hypothesis that Runx2 is responsible for signaling chondrocyte maturation and endochondral ossification in the condyle during mandibular advancement. Fifty 35-day-old Sprague-Dawley rats were fitted with functional appliances for 3, 7, 14, 21, and 30 days. Experimental animals with 50 matched controls were labeled with bromodeoxyuridine for evaluation of the invasion of chondroclasts and osteoblasts into condylar cartilage. Mandibular advancement elicited Runx2 expression in condylar cartilage, and subsequently led to an expansion of type X collagen domain in the hypertrophic layer. Stronger Runx2 mRNA signals in subchondral bone corresponded with the increase in the recruitment of osteoblasts and chondroclasts, which preceded the increase of new bone formation in the condyle. Thus, Runx2 mediates chondrocyte terminal maturation and endochondral ossification in the mandibular condyle in response to mandibular advancement.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectChondrocyteen_HK
dc.subjectMandibular condyleen_HK
dc.subjectMechanical stressen_HK
dc.subjectOsteoblasten_HK
dc.subjectRunx2en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCartilage, Articular - metabolismen_HK
dc.subject.meshChondrocytes - metabolismen_HK
dc.subject.meshCollagen Type X - metabolismen_HK
dc.subject.meshCore Binding Factor Alpha 1 Subuniten_HK
dc.subject.meshDNA-Binding Proteins - genetics - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMandibular Advancementen_HK
dc.subject.meshMandibular Condyle - metabolismen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshOsteogenesis - physiologyen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshTranscription Factor AP-2en_HK
dc.subject.meshTranscription Factors - genetics - physiologyen_HK
dc.titleRunx2 regulates endochondral ossification in condyle during mandibular advancementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=84&issue=2&spage=166&epage=171&date=2005&atitle=Runx2+regulates+endochondral+ossification+in+condyle+during+mandibular+advancementen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1177/154405910508400211en_HK
dc.identifier.pmid15668335-
dc.identifier.scopuseid_2-s2.0-15544381189en_HK
dc.identifier.hkuros98725-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15544381189&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume84en_HK
dc.identifier.issue2en_HK
dc.identifier.spage166en_HK
dc.identifier.epage171en_HK
dc.identifier.isiWOS:000226834200011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, GH=9842004300en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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