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Article: Genetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53

TitleGenetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53
Authors
Issue Date2001
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2001, v. 75 n. 1, p. 396-407 How to Cite?
AbstractRecent evidence from several investigators suggest that the human T-cell leukemia virus type 1 Tax oncoprotein represses the transcriptional activity of the tumor suppressor protein, p53. An examination of published findings reveals serious controversy as to the mechanism(s) utilized by Tax to inhibit p53 activity and whether the same mechanism is used by Tax in adherent and suspension cells. Here, we have investigated Tax-p53 interaction simultaneously in adherent epithelial (HeLa and Saos) and suspension T-lymphocyte (Jurkat) cells. Our results indicate that Tax activity through the CREB/CREB-binding protein (CBP), but not NF-κB, pathway is needed to repress the transcriptional activity of p53 in all tested cell lines. However, we did find that while CBP binding by Tax is necessary, it is not sufficient for inhibiting p53 function. Based on knockout cell studies, we correlated a strong genetic requirement for the ATM, but not protein kinase-dependent DNA, protein in conferring a Tax-p53-repressive phenotype.
Persistent Identifierhttp://hdl.handle.net/10722/49403
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorVan, PLen_HK
dc.contributor.authorYim, KWen_HK
dc.contributor.authorJin, DYen_HK
dc.contributor.authorDapolito, Gen_HK
dc.contributor.authorKurimasa, Aen_HK
dc.contributor.authorJeang, KTen_HK
dc.date.accessioned2008-06-12T06:41:37Z-
dc.date.available2008-06-12T06:41:37Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Virology, 2001, v. 75 n. 1, p. 396-407en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49403-
dc.description.abstractRecent evidence from several investigators suggest that the human T-cell leukemia virus type 1 Tax oncoprotein represses the transcriptional activity of the tumor suppressor protein, p53. An examination of published findings reveals serious controversy as to the mechanism(s) utilized by Tax to inhibit p53 activity and whether the same mechanism is used by Tax in adherent and suspension cells. Here, we have investigated Tax-p53 interaction simultaneously in adherent epithelial (HeLa and Saos) and suspension T-lymphocyte (Jurkat) cells. Our results indicate that Tax activity through the CREB/CREB-binding protein (CBP), but not NF-κB, pathway is needed to repress the transcriptional activity of p53 in all tested cell lines. However, we did find that while CBP binding by Tax is necessary, it is not sufficient for inhibiting p53 function. Based on knockout cell studies, we correlated a strong genetic requirement for the ATM, but not protein kinase-dependent DNA, protein in conferring a Tax-p53-repressive phenotype.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2001, v. 75 n. 1, p. 396-407en_HK
dc.subject.meshDNA-Binding Proteinsen_HK
dc.subject.meshGene Products, tax - physiologyen_HK
dc.subject.meshHuman T-lymphotropic virus 1 - physiologyen_HK
dc.subject.meshProtein-Serine-Threonine Kinases - physiologyen_HK
dc.subject.meshTumor Suppressor Protein p53 - physiologyen_HK
dc.titleGenetic evidence of a role for ATM in functional interaction between human T-cell leukemia virus type 1 Tax and p53en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=75&issue=1&spage=396&epage=407&date=2001&atitle=Genetic+evidence+of+a+role+for+ATM+in+functional+interaction+between+human+T-cell+leukemia+virus+type+1+Tax+and+p53en_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.75.1.396-407.2001en_HK
dc.identifier.pmid11119608-
dc.identifier.pmcidPMC113932en_HK
dc.identifier.scopuseid_2-s2.0-0034749346en_HK
dc.identifier.hkuros60397-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034749346&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue1en_HK
dc.identifier.spage396en_HK
dc.identifier.epage407en_HK
dc.identifier.isiWOS:000165863000042-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridVan, PL=8768074000en_HK
dc.identifier.scopusauthoridYim, KW=8768073500en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.scopusauthoridDapolito, G=6602818882en_HK
dc.identifier.scopusauthoridKurimasa, A=6701808936en_HK
dc.identifier.scopusauthoridJeang, KT=7004824803en_HK

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