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Article: Transcript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy

TitleTranscript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomy
Authors
KeywordsAA454543
Gene expression
Liver cancer
Overall survival
Prognosis
Issue Date2005
PublisherNeoplasia Press. The Journal's web site is located at http://www.neoplasia.org
Citation
Neoplasia, 2005, v. 7 n. 2, p. 91-98 How to Cite?
AbstractBACKGROUND: We have previously reported on the cDNA microarray gene expression profiles of hepatocellular carcinomas (HCCs). Among the genes that show prognostic significance and are overexpressed in tumor compared with adjacent nontumorous liver, transcript AA454543 may have potential for practical use. Our aim is to validate the prognostic significance of transcript AA454543 by alternative research methods and in a separate group of HCC patients. METHODS AND RESULTS: The data of transcript AA454543 derived from microarray analysis of 48 patients having curative partial hepatectomy (group 1) were verified by quantitative reverse transcription polymerase chain reaction (r = 0.618, P < .001). A separate sample set of HCCs obtained from 53 patients (group 2) was examined and the association of AA454543 expression level with overall survival was again validated (P = .027). By Cox regression analysis, transcript AA454543 [hazard ratio (HR) = 3.0, P = .017] and pathologic tumor node metastasis (pTNM) stage (HR = 3.3, P = .010) were independent prognostic factors for overall survival. The accuracy of prediction for 3-year overall survival for transcript AA454543 (74.2%, P = .001) and pTNM stage (76.4%, P = .001) was comparable as measured by the area under the receiver operating characteristic curve. CONCLUSION: Transcript AA454543 is a potentially useful molecular prognostic marker for overall survival after curative partial hepatectomy for HCC. Copyright © 2005 Neoplasia Press, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/49395
ISSN
2014 Impact Factor: 4.252
2015 SCImago Journal Rankings: 2.541
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, STen_HK
dc.contributor.authorHo, JCYen_HK
dc.contributor.authorLeung, KLen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorSo, Sen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2008-06-12T06:41:22Z-
dc.date.available2008-06-12T06:41:22Z-
dc.date.issued2005en_HK
dc.identifier.citationNeoplasia, 2005, v. 7 n. 2, p. 91-98en_HK
dc.identifier.issn1522-8002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49395-
dc.description.abstractBACKGROUND: We have previously reported on the cDNA microarray gene expression profiles of hepatocellular carcinomas (HCCs). Among the genes that show prognostic significance and are overexpressed in tumor compared with adjacent nontumorous liver, transcript AA454543 may have potential for practical use. Our aim is to validate the prognostic significance of transcript AA454543 by alternative research methods and in a separate group of HCC patients. METHODS AND RESULTS: The data of transcript AA454543 derived from microarray analysis of 48 patients having curative partial hepatectomy (group 1) were verified by quantitative reverse transcription polymerase chain reaction (r = 0.618, P < .001). A separate sample set of HCCs obtained from 53 patients (group 2) was examined and the association of AA454543 expression level with overall survival was again validated (P = .027). By Cox regression analysis, transcript AA454543 [hazard ratio (HR) = 3.0, P = .017] and pathologic tumor node metastasis (pTNM) stage (HR = 3.3, P = .010) were independent prognostic factors for overall survival. The accuracy of prediction for 3-year overall survival for transcript AA454543 (74.2%, P = .001) and pTNM stage (76.4%, P = .001) was comparable as measured by the area under the receiver operating characteristic curve. CONCLUSION: Transcript AA454543 is a potentially useful molecular prognostic marker for overall survival after curative partial hepatectomy for HCC. Copyright © 2005 Neoplasia Press, Inc. All rights reserved.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNeoplasia Press. The Journal's web site is located at http://www.neoplasia.orgen_HK
dc.relation.ispartofNeoplasiaen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAA454543en_HK
dc.subjectGene expressionen_HK
dc.subjectLiver canceren_HK
dc.subjectOverall survivalen_HK
dc.subjectPrognosisen_HK
dc.titleTranscript AA454543 is a novel prognostic marker for hepatocellular carcinoma after curative partial hepatectomyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1522-8002&volume=7&issue=2&spage=91&epage=98&date=2005&atitle=Transcript+AA454543+is+a+novel+prognostic+marker+for+hepatocellular+carcinoma+after+curative+partial+hepatectomyen_HK
dc.identifier.emailSiu, TC: stcheung@hkucc.hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.authoritySiu, TC=rp00457en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1593/neo.04472en_HK
dc.identifier.pmid15810144-
dc.identifier.pmcidPMC1501123en_HK
dc.identifier.scopuseid_2-s2.0-14644388800en_HK
dc.identifier.hkuros97638-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14644388800&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue2en_HK
dc.identifier.spage91en_HK
dc.identifier.epage98en_HK
dc.identifier.isiWOS:000227413800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSiu, TC=7202473497en_HK
dc.identifier.scopusauthoridHo, JCY=7402650284en_HK
dc.identifier.scopusauthoridKa, LL=36821606200en_HK
dc.identifier.scopusauthoridChen, X=36142632800en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridSo, S=7102397384en_HK
dc.identifier.scopusauthoridSheung, TF=6506234707en_HK

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