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Article: Molecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in China
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TitleMolecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in China
 
AuthorsZhang, L4 3 2
Chen, Z4
Cao, Y4 3
Yu, J4
Li, G3
Yu, W4
Yin, N3
Mei, S3
Li, L3
Balfe, P4
He, T4
Ba, L4
Zhang, F4
Lin, HH4
Yuen, MF1
Lai, CL1
Ho, DD4
 
Issue Date2004
 
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
CitationJournal Of Virology, 2004, v. 78 n. 24, p. 13591-13599 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.78.24.13591-13599.2004
 
AbstractChina is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users (IDU), and sexual partners of infected individuals. In this report, a total of 236 HIV-1-positive blood samples were collected from PBD, IDU, and their sexual partners in the most severely affected provinces, such as Henan, Yunnan, Guangxi, and Xinjiang. PCR was used to amplify the p17 region of gag and the C2-V3 region of env of HIV-1 and the 5′ noncoding region and a region of E1/E2 of HCV. Genetic characterization of viral sequences indicated that there are two major epidemics of HIV-1 and multiple HCV epidemics in China. The PBD and transfusion recipients in Henan harbored HIV-1 subtype B', which is similar to the virus found in Thailand, and HCV genotypes 1b and 2a, whereas the IDU in Yunnan, Guangxi, and Xinjiang carried HIV-1 circulating recombinant forms 07 and 08, which resemble those in India, and HCV genotypes 1b, 3a, and 3b. Our findings show that the epidemics of HIV-1 and HCV infection in China are the consequences of multiple introductions. The distinct distribution patterns of both the HIV-1 and HCV genotypes in the different high-risk groups are tightly linked to the mode of transmission rather than geographic proximity. These findings provide information relevant to antiviral therapy and vaccine development in China and should assist public health workers in implementing measures to reduce the further dissemination of these viruses in the world's most populous nation.
 
ISSN0022-538X
2013 Impact Factor: 4.648
 
DOIhttp://dx.doi.org/10.1128/JVI.78.24.13591-13599.2004
 
PubMed Central IDPMC533913
 
ISI Accession Number IDWOS:000225409900021
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, L
 
dc.contributor.authorChen, Z
 
dc.contributor.authorCao, Y
 
dc.contributor.authorYu, J
 
dc.contributor.authorLi, G
 
dc.contributor.authorYu, W
 
dc.contributor.authorYin, N
 
dc.contributor.authorMei, S
 
dc.contributor.authorLi, L
 
dc.contributor.authorBalfe, P
 
dc.contributor.authorHe, T
 
dc.contributor.authorBa, L
 
dc.contributor.authorZhang, F
 
dc.contributor.authorLin, HH
 
dc.contributor.authorYuen, MF
 
dc.contributor.authorLai, CL
 
dc.contributor.authorHo, DD
 
dc.date.accessioned2008-06-12T06:35:10Z
 
dc.date.available2008-06-12T06:35:10Z
 
dc.date.issued2004
 
dc.description.abstractChina is facing a rapid upsurge in cases of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) infection due to large numbers of paid blood donors (PBD), injection drug users (IDU), and sexual partners of infected individuals. In this report, a total of 236 HIV-1-positive blood samples were collected from PBD, IDU, and their sexual partners in the most severely affected provinces, such as Henan, Yunnan, Guangxi, and Xinjiang. PCR was used to amplify the p17 region of gag and the C2-V3 region of env of HIV-1 and the 5′ noncoding region and a region of E1/E2 of HCV. Genetic characterization of viral sequences indicated that there are two major epidemics of HIV-1 and multiple HCV epidemics in China. The PBD and transfusion recipients in Henan harbored HIV-1 subtype B', which is similar to the virus found in Thailand, and HCV genotypes 1b and 2a, whereas the IDU in Yunnan, Guangxi, and Xinjiang carried HIV-1 circulating recombinant forms 07 and 08, which resemble those in India, and HCV genotypes 1b, 3a, and 3b. Our findings show that the epidemics of HIV-1 and HCV infection in China are the consequences of multiple introductions. The distinct distribution patterns of both the HIV-1 and HCV genotypes in the different high-risk groups are tightly linked to the mode of transmission rather than geographic proximity. These findings provide information relevant to antiviral therapy and vaccine development in China and should assist public health workers in implementing measures to reduce the further dissemination of these viruses in the world's most populous nation.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent386 bytes
 
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dc.identifier.citationJournal Of Virology, 2004, v. 78 n. 24, p. 13591-13599 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JVI.78.24.13591-13599.2004
 
dc.identifier.doihttp://dx.doi.org/10.1128/JVI.78.24.13591-13599.2004
 
dc.identifier.epage13599
 
dc.identifier.hkuros97681
 
dc.identifier.isiWOS:000225409900021
 
dc.identifier.issn0022-538X
2013 Impact Factor: 4.648
 
dc.identifier.issue24
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC533913
 
dc.identifier.pmid15564470
 
dc.identifier.scopuseid_2-s2.0-10044230829
 
dc.identifier.spage13591
 
dc.identifier.urihttp://hdl.handle.net/10722/49135
 
dc.identifier.volume78
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Virology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2004, v. 78 n. 24, p. 13591-13599
 
dc.subject.meshBlood Donors
 
dc.subject.meshHIV Infections - epidemiology - virology
 
dc.subject.meshHIV-1 - classification - genetics
 
dc.subject.meshHepacivirus - classification - genetics
 
dc.subject.meshHepatitis C - epidemiology - virology
 
dc.titleMolecular characterization of human immunodeficiency virus type 1 and hepatitis C virus in paid blood donors and injection drug users in China
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Aaron Diamond AIDS Research Center
  3. Chinese Academy of Medical Sciences
  4. Rockefeller University