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Article: Determinants for the occurrence of acute exacerbation of hepatitis B virus infection in Chinese patients after HBeAg seroclearance

TitleDeterminants for the occurrence of acute exacerbation of hepatitis B virus infection in Chinese patients after HBeAg seroclearance
Authors
Issue Date2005
PublisherAmerican Society for Microbiology.
Citation
Journal Of Clinical Microbiology, 2005, v. 43 n. 4, p. 1594-1599 How to Cite?
AbstractThis study was performed to determine the factors for predicting the occurrence of acute exacerbation of hepatitis B virus infection in HBeAg-negative patients. Two hundred and sixteen patients with known times of HBeAg seroclearance were recruited. Liver biochemistry and virologic markers were monitored. Precore and core promoter mutations were determined by a line probe assay. The median age at HBeAg seroclearance was 34.5 years. The median follow-up duration was 26.4 months. Fifty-six (27.9%) patients had acute exacerbations. By Cox regression analysis, male gender, older age, and core promoter mutations at the time of HBeAg seroclearance were independently associated with the occurrence of acute exacerbation after HBeAg seroclearance (P = 0.025, 0.018, and 0.001, respectively). Fourteen (7.0%) patients had HBeAg seroreversion within a median follow-up period of 11.6 months after HBeAg seroclearance. By Cox regression analysis, older age at HBeAg seroclearance was independently associated with the chance of HBeAg seroreversion (P = 0.01). We concluded that male patients with core promoter mutations and delayed HBeAg seroclearance had a higher cumulative chance of acute exacerbation in the HBeAg-negative phase. Patients with delayed HBeAg seroclearance had a higher frequency of HBeAg seroreversion. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/49134
ISSN
2015 Impact Factor: 3.631
2015 SCImago Journal Rankings: 2.151
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, HJen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorSum, SMen_HK
dc.contributor.authorDoutreloigne, Jen_HK
dc.contributor.authorSablon, Een_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2008-06-12T06:35:09Z-
dc.date.available2008-06-12T06:35:09Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Clinical Microbiology, 2005, v. 43 n. 4, p. 1594-1599en_HK
dc.identifier.issn0095-1137en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49134-
dc.description.abstractThis study was performed to determine the factors for predicting the occurrence of acute exacerbation of hepatitis B virus infection in HBeAg-negative patients. Two hundred and sixteen patients with known times of HBeAg seroclearance were recruited. Liver biochemistry and virologic markers were monitored. Precore and core promoter mutations were determined by a line probe assay. The median age at HBeAg seroclearance was 34.5 years. The median follow-up duration was 26.4 months. Fifty-six (27.9%) patients had acute exacerbations. By Cox regression analysis, male gender, older age, and core promoter mutations at the time of HBeAg seroclearance were independently associated with the occurrence of acute exacerbation after HBeAg seroclearance (P = 0.025, 0.018, and 0.001, respectively). Fourteen (7.0%) patients had HBeAg seroreversion within a median follow-up period of 11.6 months after HBeAg seroclearance. By Cox regression analysis, older age at HBeAg seroclearance was independently associated with the chance of HBeAg seroreversion (P = 0.01). We concluded that male patients with core promoter mutations and delayed HBeAg seroclearance had a higher cumulative chance of acute exacerbation in the HBeAg-negative phase. Patients with delayed HBeAg seroclearance had a higher frequency of HBeAg seroreversion. Copyright © 2005, American Society for Microbiology. All Rights Reserved.en_HK
dc.format.extent394 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofJournal of Clinical Microbiologyen_HK
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Journal of Clinical Microbiology, 2005, v. 43 n. 4, p. 1594-1599en_HK
dc.subject.meshHepatitis B e Antigens - blooden_HK
dc.subject.meshHepatitis B virus - genetics - isolation & purification - pathogenicityen_HK
dc.subject.meshHepatitis B, Chronic - physiopathology - virologyen_HK
dc.subject.meshLiver Function Testsen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.titleDeterminants for the occurrence of acute exacerbation of hepatitis B virus infection in Chinese patients after HBeAg seroclearanceen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0095-1137&volume=43&issue=4&spage=1594&epage=1599&date=2005&atitle=Determinants+for+the+occurrence+of+acute+exacerbation+of+hepatitis+B+virus+infection+in+Chinese+patients+after+HBeAg+seroclearanceen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, DKH:danywong@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JCM.43.4.1594-1599.2005en_HK
dc.identifier.pmid15814971-
dc.identifier.pmcidPMC1081372en_HK
dc.identifier.scopuseid_2-s2.0-16844380547en_HK
dc.identifier.hkuros97680-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-16844380547&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1594en_HK
dc.identifier.epage1599en_HK
dc.identifier.isiWOS:000228404100014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuan, HJ=7402446707en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridSum, SM=6603889132en_HK
dc.identifier.scopusauthoridDoutreloigne, J=6603727456en_HK
dc.identifier.scopusauthoridSablon, E=6603694538en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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