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Article: Hepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core gene

TitleHepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core gene
Authors
Issue Date2002
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2002, v. 76 n. 12, p. 5985-5992 How to Cite?
AbstractThe entire nucleotide sequences of 70 hepatitis B virus (HBV) isolates of genotype B (HBV/B), including 38 newly determined and 32 retrieved from the international DNA database (DDBJ/EMBL/GenBank), were compared phylogenetically. Two subgroups of HBV/B were identified based on sequence divergence in the precore region plus the core gene, one with the recombination with genotype C and the other without it. The analysis over the entire genome of HBV/B by the SimPlot program located the recombination with genotype C in the precore region plus the core gene spanning nucleotide positions from 1740 to 1838 to 2443 to 2485. Within this genomic area, HBV/B strains with the recombination had higher nucleotide and amino acid homology to genotype C than those without the recombination (96.9 versus 91.1% in nucleotides and 97.0 versus 92.9% in amino acids). There were 29 HBV/B strains without the recombination, and they were all recovered from carriers in Japan. The remaining 41 HBV/B isolates having the recombination with genotype C were from carriers in China (12 strains), Hong Kong (3 strains), Indonesia (4 strains), Japan (3 strains), Taiwan (4 strains), Thailand (3 strains), and Vietnam (12 strains). Due to the frequency of the distribution of HBV/B without the recombination (29 of 32 isolates, or 91%) and the fact that it was exclusive to Japan, it was provisionally classified into the Bj (j standing for Japan) subgroup, and HBV/B with the recombination was classified into the Ba (a for Asia) subgroup. Virological differences between HBV/Bj and HBV/Ba may be reflected in the severity of clinical disease in the patients infected with HBV of genotype B, which seems to be under strong geographic influences in Asia.
Persistent Identifierhttp://hdl.handle.net/10722/49118
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSugauchi, Fen_HK
dc.contributor.authorOrito, Een_HK
dc.contributor.authorIchida, Ten_HK
dc.contributor.authorKato, Hen_HK
dc.contributor.authorSakugawa, Hen_HK
dc.contributor.authorKakumu, Sen_HK
dc.contributor.authorIshida, Ten_HK
dc.contributor.authorChutaputti, Aen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorUeda, Ren_HK
dc.contributor.authorMiyakawa, Yen_HK
dc.contributor.authorMizokami, Men_HK
dc.date.accessioned2008-06-12T06:34:49Z-
dc.date.available2008-06-12T06:34:49Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Virology, 2002, v. 76 n. 12, p. 5985-5992en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49118-
dc.description.abstractThe entire nucleotide sequences of 70 hepatitis B virus (HBV) isolates of genotype B (HBV/B), including 38 newly determined and 32 retrieved from the international DNA database (DDBJ/EMBL/GenBank), were compared phylogenetically. Two subgroups of HBV/B were identified based on sequence divergence in the precore region plus the core gene, one with the recombination with genotype C and the other without it. The analysis over the entire genome of HBV/B by the SimPlot program located the recombination with genotype C in the precore region plus the core gene spanning nucleotide positions from 1740 to 1838 to 2443 to 2485. Within this genomic area, HBV/B strains with the recombination had higher nucleotide and amino acid homology to genotype C than those without the recombination (96.9 versus 91.1% in nucleotides and 97.0 versus 92.9% in amino acids). There were 29 HBV/B strains without the recombination, and they were all recovered from carriers in Japan. The remaining 41 HBV/B isolates having the recombination with genotype C were from carriers in China (12 strains), Hong Kong (3 strains), Indonesia (4 strains), Japan (3 strains), Taiwan (4 strains), Thailand (3 strains), and Vietnam (12 strains). Due to the frequency of the distribution of HBV/B without the recombination (29 of 32 isolates, or 91%) and the fact that it was exclusive to Japan, it was provisionally classified into the Bj (j standing for Japan) subgroup, and HBV/B with the recombination was classified into the Ba (a for Asia) subgroup. Virological differences between HBV/Bj and HBV/Ba may be reflected in the severity of clinical disease in the patients infected with HBV of genotype B, which seems to be under strong geographic influences in Asia.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.en_HK
dc.rightsCopyright © American Society for Microbiology, Journal of Virology, 2002, v. 76 n. 12, p. 5985-5992en_HK
dc.subject.meshHepatitis B virus - classification - geneticsen_HK
dc.subject.meshProtein Precursors - geneticsen_HK
dc.subject.meshRecombination, Geneticen_HK
dc.subject.meshViral Core Proteins - geneticsen_HK
dc.subject.meshMolecular Sequence Dataen_HK
dc.titleHepatitis B virus of genotype B with or without recombination with genotype C over the precore region plus the core geneen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-538X&volume=76&issue=12&spage=5985&epage=5992&date=2002&atitle=Hepatitis+B+virus+of+genotype+B+with+or+without+recombination+with+genotype+C+over+the+precore+region+plus+the+core+geneen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/JVI.76.12.5985-5992.2002en_HK
dc.identifier.pmid12021331-
dc.identifier.pmcidPMC136227en_HK
dc.identifier.scopuseid_2-s2.0-0036100298en_HK
dc.identifier.hkuros70845-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036100298&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue12en_HK
dc.identifier.spage5985en_HK
dc.identifier.epage5992en_HK
dc.identifier.isiWOS:000175912200015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSugauchi, F=7004837927en_HK
dc.identifier.scopusauthoridOrito, E=7006161634en_HK
dc.identifier.scopusauthoridIchida, T=7102582635en_HK
dc.identifier.scopusauthoridKato, H=7406496874en_HK
dc.identifier.scopusauthoridSakugawa, H=7006875192en_HK
dc.identifier.scopusauthoridKakumu, S=7007147262en_HK
dc.identifier.scopusauthoridIshida, T=35353530100en_HK
dc.identifier.scopusauthoridChutaputti, A=6603176195en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridUeda, R=35376281000en_HK
dc.identifier.scopusauthoridMiyakawa, Y=7102670114en_HK
dc.identifier.scopusauthoridMizokami, M=7103318255en_HK

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