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Article: Potential benefit of plasma exchange in treatment of severe icteric leptospirosis complicated by acute renal failure

TitlePotential benefit of plasma exchange in treatment of severe icteric leptospirosis complicated by acute renal failure
Authors
Issue Date2002
PublisherAmerican Society for Microbiology.
Citation
Clinical And Diagnostic Laboratory Immunology, 2002, v. 9 n. 2, p. 482-484 How to Cite?
AbstractLeptospirosis is a common zoonosis seen worldwide, but it is rare in our locality (Hong Kong). Clinical manifestations of leptospirosis are variable and may range from subclinical infection to fever, jaundice, hemorrhagic tendency, and fulminant hepato-renal failure. Severe hyperbilirubinemia and acute renal failure have been associated with high mortality. We report our experience with a patient who developed severe Weil's syndrome with marked conjugated hyperbilirubinemia and oliguric acute renal failure. These complications persisted despite treatment with penicillin and hemodiafiltration. Plasma exchange was instituted in view of the severe hyperbilirubinemia (970 μmol/liter). This was followed by prompt clinical improvement, with recovery of liver and renal function. The beneficial effects of plasma exchange could be attributed to amelioration of the toxic effects of hyperbilirubinemia on hepatocyte and renal tubular cell function. We conclude that plasma exchange should be considered as an adjunctive therapy for patients with severe icteric leptospirosis complicated by acute renal failure who have not shown rapid clinical response to conventional treatment.
Persistent Identifierhttp://hdl.handle.net/10722/49114
ISSN
2007 Impact Factor: 2.511
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, KCen_HK
dc.contributor.authorYip, PSen_HK
dc.contributor.authorHui, KMen_HK
dc.contributor.authorLi, FKen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorLai, KNen_HK
dc.contributor.authorChan, TMen_HK
dc.date.accessioned2008-06-12T06:34:44Z-
dc.date.available2008-06-12T06:34:44Z-
dc.date.issued2002en_HK
dc.identifier.citationClinical And Diagnostic Laboratory Immunology, 2002, v. 9 n. 2, p. 482-484en_HK
dc.identifier.issn1071-412Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/49114-
dc.description.abstractLeptospirosis is a common zoonosis seen worldwide, but it is rare in our locality (Hong Kong). Clinical manifestations of leptospirosis are variable and may range from subclinical infection to fever, jaundice, hemorrhagic tendency, and fulminant hepato-renal failure. Severe hyperbilirubinemia and acute renal failure have been associated with high mortality. We report our experience with a patient who developed severe Weil's syndrome with marked conjugated hyperbilirubinemia and oliguric acute renal failure. These complications persisted despite treatment with penicillin and hemodiafiltration. Plasma exchange was instituted in view of the severe hyperbilirubinemia (970 μmol/liter). This was followed by prompt clinical improvement, with recovery of liver and renal function. The beneficial effects of plasma exchange could be attributed to amelioration of the toxic effects of hyperbilirubinemia on hepatocyte and renal tubular cell function. We conclude that plasma exchange should be considered as an adjunctive therapy for patients with severe icteric leptospirosis complicated by acute renal failure who have not shown rapid clinical response to conventional treatment.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology.en_HK
dc.relation.ispartofClinical and Diagnostic Laboratory Immunologyen_HK
dc.rightsClinical and Diagnostic Laboratory Immunology. Copyright © American Society for Microbiology.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © American Society for Microbiology, Clinical and Diagnostic Laboratory Immunology, 2002, v. 9 n. 2, p. 482-484en_HK
dc.subject.meshKidney Failure, Acute - microbiologyen_HK
dc.subject.meshPlasma Exchangeen_HK
dc.subject.meshWeil Disease - complications - therapyen_HK
dc.subject.meshHyperbilirubinemia - complications - microbiology - therapyen_HK
dc.subject.meshJaundice - complications - microbiology - therapyen_HK
dc.titlePotential benefit of plasma exchange in treatment of severe icteric leptospirosis complicated by acute renal failureen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1071-412X&volume=9&issue=2&spage=482&epage=484&date=2002&atitle=Potential+benefit+of+plasma+exchange+in+treatment+of+severe+icteric+leptospirosis+complicated+by+acute+renal+failure+en_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1128/CDLI.9.2.482-484.2002en_HK
dc.identifier.pmid11874897-
dc.identifier.pmcidPMC119963en_HK
dc.identifier.scopuseid_2-s2.0-0036128451en_HK
dc.identifier.hkuros67555-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036128451&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue2en_HK
dc.identifier.spage482en_HK
dc.identifier.epage484en_HK
dc.identifier.isiWOS:000174457600044-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, KC=7102609864en_HK
dc.identifier.scopusauthoridYip, PS=14219904600en_HK
dc.identifier.scopusauthoridHui, KM=7103304777en_HK
dc.identifier.scopusauthoridLi, FK=8219093900en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK

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