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Article: Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers: Clinical and biological implications

TitleClassification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers: Clinical and biological implications
Authors
Issue Date1996
PublisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.org
Citation
American Journal Of Pathology, 1996, v. 149 n. 4, p. 1167-1175 How to Cite?
AbstractHepatocellular carcinoma (HCC) is a heterogeneous disease. HCC derived from different stages of cellular differentiation may have different clinical and pathobiological behavior. To test the hypothesis that HCC can be classified into two types based on its phenotypic markers (hepatocellular and biliary differentiation), liver tissues from 290 Chinese patients with HCC were studied. Expression of hepatocytic differentiation marker (HEP-PAR- reactive antigen), biliary differentiation markers (AE1-AE3, cyrokeratin- 19), proliferation markers (Ki-67, proliferating cell nuclear antigen), α- fetoprotein, p53, and transforming growth factor-α in the tumor tissue were assessed by immunohistochemistry. Hepatocytic differentiation marker was detected in 99.7% and biliary differentiation markers were detected in 29.3% of these tumors. Clinically, no patient with HCC with biliary markers survived for more than 27 weeks compared with a 22.6% survival rate in patients with HCC negative for biliary markers. HCCs positive for the biliary differentiation markers showed features of more aggressive disease in terms of poorer cellular differentiation (P < 0.001) and high-level expression of proliferation markers (Ki-67, P < 0.001: proliferating cell nuclear antigen, P = 0.0114) compared with HCCs without biliary markers. HCCs with biliary markers also had a higher level of expression of α-fetoprotein (P < 0.001) and p53 (P = 0.0077). Classification of HCCs based on its phenotypic (differentiation) markers has both clinical and pathobiological implications.
Persistent Identifierhttp://hdl.handle.net/10722/49064
ISSN
2015 Impact Factor: 4.206
2015 SCImago Journal Rankings: 2.653
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWu, PCen_HK
dc.contributor.authorFang, JWSen_HK
dc.contributor.authorLau, VKTen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLo, CKen_HK
dc.contributor.authorLau, JYNen_HK
dc.date.accessioned2008-06-12T06:33:37Z-
dc.date.available2008-06-12T06:33:37Z-
dc.date.issued1996en_HK
dc.identifier.citationAmerican Journal Of Pathology, 1996, v. 149 n. 4, p. 1167-1175en_HK
dc.identifier.issn0002-9440en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49064-
dc.description.abstractHepatocellular carcinoma (HCC) is a heterogeneous disease. HCC derived from different stages of cellular differentiation may have different clinical and pathobiological behavior. To test the hypothesis that HCC can be classified into two types based on its phenotypic markers (hepatocellular and biliary differentiation), liver tissues from 290 Chinese patients with HCC were studied. Expression of hepatocytic differentiation marker (HEP-PAR- reactive antigen), biliary differentiation markers (AE1-AE3, cyrokeratin- 19), proliferation markers (Ki-67, proliferating cell nuclear antigen), α- fetoprotein, p53, and transforming growth factor-α in the tumor tissue were assessed by immunohistochemistry. Hepatocytic differentiation marker was detected in 99.7% and biliary differentiation markers were detected in 29.3% of these tumors. Clinically, no patient with HCC with biliary markers survived for more than 27 weeks compared with a 22.6% survival rate in patients with HCC negative for biliary markers. HCCs positive for the biliary differentiation markers showed features of more aggressive disease in terms of poorer cellular differentiation (P < 0.001) and high-level expression of proliferation markers (Ki-67, P < 0.001: proliferating cell nuclear antigen, P = 0.0114) compared with HCCs without biliary markers. HCCs with biliary markers also had a higher level of expression of α-fetoprotein (P < 0.001) and p53 (P = 0.0077). Classification of HCCs based on its phenotypic (differentiation) markers has both clinical and pathobiological implications.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Society for Investigative Pathology. The Journal's web site is located at http://www.amjpathol.orgen_HK
dc.relation.ispartofAmerican Journal of Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntigens, Differentiation - analysisen_HK
dc.subject.meshBile Ducts - immunologyen_HK
dc.subject.meshCarcinoma, Hepatocellular - classification - immunology - mortality - pathologyen_HK
dc.subject.meshLiver - immunologyen_HK
dc.subject.meshLiver Neoplasms - classification - immunology - mortality - pathologyen_HK
dc.titleClassification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers: Clinical and biological implicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9440&volume=149&issue=4&spage=1167&epage=1175&date=1996&atitle=Classification+of+hepatocellular+carcinoma+according+to+hepatocellular+and+biliary+differentiation+markers:+clinical+and+biological+implicationsen_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8863666-
dc.identifier.pmcidPMC1865193-
dc.identifier.scopuseid_2-s2.0-0029794269en_HK
dc.identifier.hkuros26081-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029794269&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume149en_HK
dc.identifier.issue4en_HK
dc.identifier.spage1167en_HK
dc.identifier.epage1175en_HK
dc.identifier.isiWOS:A1996VM31400011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWu, PC=7403119323en_HK
dc.identifier.scopusauthoridFang, JWS=7402963750en_HK
dc.identifier.scopusauthoridLau, VKT=16935685000en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridLo, CK=16413500600en_HK
dc.identifier.scopusauthoridLau, JYN=7402446047en_HK

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