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Article: Apolipoprotein (a) levels and phenotypes in NIDDM patients with microalbuminuria and albuminuria
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TitleApolipoprotein (a) levels and phenotypes in NIDDM patients with microalbuminuria and albuminuria
 
AuthorsLam, KSL1
Pang, RWC1
Wat, MS1
Lauder, IJ1
Janus, ED1
 
KeywordsApolipoprotein (a) phenotype
Chinese
Lipoprotein (a)
Lipoproteins
Microalbuminuria
NIDDM
 
Issue Date1996
 
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
 
CitationNephrology Dialysis Transplantation, 1996, v. 11 n. 11, p. 2229-2236 [How to Cite?]
 
AbstractThis study was conducted to determine whether circulating levels of lipoprotein (a), an independent risk factor of macrovascular disease, are increased in non-insulin-dependent diabetes mellitus (NIDDM) patients with microalbuminuria who have an increased risk of cardiovascular mortality. Apolipoprotein (a) [apo(a)] levels and phenotypes, and other circulating lipid levels were determined in 227 Chinese NIDDM patients with varying stages of diabetic nephropathy. None was on lipid-lowering therapy. Apo(a) levels in normoalbuminuric (geometric mean 166 U/L; 95% confidence intervals 137, 200; n = 105) and microalbuminuric patients (162; 132, 209; n = 77) were similar to values in controls (166; 143, 193, n = 168). Albuminuric patients, however, higher apo(a) levels than both normoalbuminuric and controls (242; 184, 317 n = 45; P < 0.05). The overall size range of the apo(a) phenotypes and the frequency of having at least one small isoform, i.e. < 700 kDa, were similar among the four groups of subjects. A positive correlation was found between log apo(a) and log plasma creatinine levels (P < 0.01). Compared to normoalbuminuric patients, both microalbuminuric and albuminuric patients were older (P < 0.01) and had higher HbAlc (P < 0.01), greater BMI(P < 0.05) and longer disease duration (P < 0.05) compared to normoalbuminuric patients. Nevertheless, using multiple linear regression analysis, it was found that the presence of nephropathy conferred an independent influence on increasing total cholesterol (P < 0.001), triglyceride (P < 0.001) and apoB (P < 0.01), and decreasing HDL cholesterol (P < 0.05) levels even when only the normoalbuminuric and microalbuminuric groups were analysed. The prevalence of macrovascular disease was significantly increased in microalbuminuric and albuminuric patients (45.1 and 48.7% respectively vs 20.2% in normoalbuminuric patients, P < 0.01). It is concluded that circulating apo(a) levels were not increased in Chinese NIDDM patients with microalbuminuria. However, atherogenic changes in other lipid and lipoprotein levels may contribute to an increased risk of macrovascular disease in these patients.
 
ISSN0931-0509
2012 Impact Factor: 3.371
2012 SCImago Journal Rankings: 1.426
 
ISI Accession Number IDWOS:A1996VT93100023
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLam, KSL
 
dc.contributor.authorPang, RWC
 
dc.contributor.authorWat, MS
 
dc.contributor.authorLauder, IJ
 
dc.contributor.authorJanus, ED
 
dc.date.accessioned2008-06-12T06:33:31Z
 
dc.date.available2008-06-12T06:33:31Z
 
dc.date.issued1996
 
dc.description.abstractThis study was conducted to determine whether circulating levels of lipoprotein (a), an independent risk factor of macrovascular disease, are increased in non-insulin-dependent diabetes mellitus (NIDDM) patients with microalbuminuria who have an increased risk of cardiovascular mortality. Apolipoprotein (a) [apo(a)] levels and phenotypes, and other circulating lipid levels were determined in 227 Chinese NIDDM patients with varying stages of diabetic nephropathy. None was on lipid-lowering therapy. Apo(a) levels in normoalbuminuric (geometric mean 166 U/L; 95% confidence intervals 137, 200; n = 105) and microalbuminuric patients (162; 132, 209; n = 77) were similar to values in controls (166; 143, 193, n = 168). Albuminuric patients, however, higher apo(a) levels than both normoalbuminuric and controls (242; 184, 317 n = 45; P < 0.05). The overall size range of the apo(a) phenotypes and the frequency of having at least one small isoform, i.e. < 700 kDa, were similar among the four groups of subjects. A positive correlation was found between log apo(a) and log plasma creatinine levels (P < 0.01). Compared to normoalbuminuric patients, both microalbuminuric and albuminuric patients were older (P < 0.01) and had higher HbAlc (P < 0.01), greater BMI(P < 0.05) and longer disease duration (P < 0.05) compared to normoalbuminuric patients. Nevertheless, using multiple linear regression analysis, it was found that the presence of nephropathy conferred an independent influence on increasing total cholesterol (P < 0.001), triglyceride (P < 0.001) and apoB (P < 0.01), and decreasing HDL cholesterol (P < 0.05) levels even when only the normoalbuminuric and microalbuminuric groups were analysed. The prevalence of macrovascular disease was significantly increased in microalbuminuric and albuminuric patients (45.1 and 48.7% respectively vs 20.2% in normoalbuminuric patients, P < 0.01). It is concluded that circulating apo(a) levels were not increased in Chinese NIDDM patients with microalbuminuria. However, atherogenic changes in other lipid and lipoprotein levels may contribute to an increased risk of macrovascular disease in these patients.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent418 bytes
 
dc.format.mimetypetext/html
 
dc.identifier.citationNephrology Dialysis Transplantation, 1996, v. 11 n. 11, p. 2229-2236 [How to Cite?]
 
dc.identifier.epage2236
 
dc.identifier.hkuros22863
 
dc.identifier.isiWOS:A1996VT93100023
 
dc.identifier.issn0931-0509
2012 Impact Factor: 3.371
2012 SCImago Journal Rankings: 1.426
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmid8941583
 
dc.identifier.scopuseid_2-s2.0-0029854018
 
dc.identifier.spage2229
 
dc.identifier.urihttp://hdl.handle.net/10722/49059
 
dc.identifier.volume11
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofNephrology Dialysis Transplantation
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectApolipoprotein (a) phenotype
 
dc.subjectChinese
 
dc.subjectLipoprotein (a)
 
dc.subjectLipoproteins
 
dc.subjectMicroalbuminuria
 
dc.subjectNIDDM
 
dc.titleApolipoprotein (a) levels and phenotypes in NIDDM patients with microalbuminuria and albuminuria
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong