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Article: Apolipoprotein (a) levels and phenotypes in NIDDM patients with microalbuminuria and albuminuria

TitleApolipoprotein (a) levels and phenotypes in NIDDM patients with microalbuminuria and albuminuria
Authors
KeywordsApolipoprotein (a) phenotype
Chinese
Lipoprotein (a)
Lipoproteins
Microalbuminuria
NIDDM
Issue Date1996
PublisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/
Citation
Nephrology Dialysis Transplantation, 1996, v. 11 n. 11, p. 2229-2236 How to Cite?
Abstract
This study was conducted to determine whether circulating levels of lipoprotein (a), an independent risk factor of macrovascular disease, are increased in non-insulin-dependent diabetes mellitus (NIDDM) patients with microalbuminuria who have an increased risk of cardiovascular mortality. Apolipoprotein (a) [apo(a)] levels and phenotypes, and other circulating lipid levels were determined in 227 Chinese NIDDM patients with varying stages of diabetic nephropathy. None was on lipid-lowering therapy. Apo(a) levels in normoalbuminuric (geometric mean 166 U/L; 95% confidence intervals 137, 200; n = 105) and microalbuminuric patients (162; 132, 209; n = 77) were similar to values in controls (166; 143, 193, n = 168). Albuminuric patients, however, higher apo(a) levels than both normoalbuminuric and controls (242; 184, 317 n = 45; P < 0.05). The overall size range of the apo(a) phenotypes and the frequency of having at least one small isoform, i.e. < 700 kDa, were similar among the four groups of subjects. A positive correlation was found between log apo(a) and log plasma creatinine levels (P < 0.01). Compared to normoalbuminuric patients, both microalbuminuric and albuminuric patients were older (P < 0.01) and had higher HbAlc (P < 0.01), greater BMI(P < 0.05) and longer disease duration (P < 0.05) compared to normoalbuminuric patients. Nevertheless, using multiple linear regression analysis, it was found that the presence of nephropathy conferred an independent influence on increasing total cholesterol (P < 0.001), triglyceride (P < 0.001) and apoB (P < 0.01), and decreasing HDL cholesterol (P < 0.05) levels even when only the normoalbuminuric and microalbuminuric groups were analysed. The prevalence of macrovascular disease was significantly increased in microalbuminuric and albuminuric patients (45.1 and 48.7% respectively vs 20.2% in normoalbuminuric patients, P < 0.01). It is concluded that circulating apo(a) levels were not increased in Chinese NIDDM patients with microalbuminuria. However, atherogenic changes in other lipid and lipoprotein levels may contribute to an increased risk of macrovascular disease in these patients.
Persistent Identifierhttp://hdl.handle.net/10722/49059
ISSN
2013 Impact Factor: 3.488
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorPang, RWCen_HK
dc.contributor.authorWat, MSen_HK
dc.contributor.authorLauder, IJen_HK
dc.contributor.authorJanus, EDen_HK
dc.date.accessioned2008-06-12T06:33:31Z-
dc.date.available2008-06-12T06:33:31Z-
dc.date.issued1996en_HK
dc.identifier.citationNephrology Dialysis Transplantation, 1996, v. 11 n. 11, p. 2229-2236en_HK
dc.identifier.issn0931-0509en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49059-
dc.description.abstractThis study was conducted to determine whether circulating levels of lipoprotein (a), an independent risk factor of macrovascular disease, are increased in non-insulin-dependent diabetes mellitus (NIDDM) patients with microalbuminuria who have an increased risk of cardiovascular mortality. Apolipoprotein (a) [apo(a)] levels and phenotypes, and other circulating lipid levels were determined in 227 Chinese NIDDM patients with varying stages of diabetic nephropathy. None was on lipid-lowering therapy. Apo(a) levels in normoalbuminuric (geometric mean 166 U/L; 95% confidence intervals 137, 200; n = 105) and microalbuminuric patients (162; 132, 209; n = 77) were similar to values in controls (166; 143, 193, n = 168). Albuminuric patients, however, higher apo(a) levels than both normoalbuminuric and controls (242; 184, 317 n = 45; P < 0.05). The overall size range of the apo(a) phenotypes and the frequency of having at least one small isoform, i.e. < 700 kDa, were similar among the four groups of subjects. A positive correlation was found between log apo(a) and log plasma creatinine levels (P < 0.01). Compared to normoalbuminuric patients, both microalbuminuric and albuminuric patients were older (P < 0.01) and had higher HbAlc (P < 0.01), greater BMI(P < 0.05) and longer disease duration (P < 0.05) compared to normoalbuminuric patients. Nevertheless, using multiple linear regression analysis, it was found that the presence of nephropathy conferred an independent influence on increasing total cholesterol (P < 0.001), triglyceride (P < 0.001) and apoB (P < 0.01), and decreasing HDL cholesterol (P < 0.05) levels even when only the normoalbuminuric and microalbuminuric groups were analysed. The prevalence of macrovascular disease was significantly increased in microalbuminuric and albuminuric patients (45.1 and 48.7% respectively vs 20.2% in normoalbuminuric patients, P < 0.01). It is concluded that circulating apo(a) levels were not increased in Chinese NIDDM patients with microalbuminuria. However, atherogenic changes in other lipid and lipoprotein levels may contribute to an increased risk of macrovascular disease in these patients.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/en_HK
dc.relation.ispartofNephrology Dialysis Transplantationen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectApolipoprotein (a) phenotypeen_HK
dc.subjectChineseen_HK
dc.subjectLipoprotein (a)en_HK
dc.subjectLipoproteinsen_HK
dc.subjectMicroalbuminuriaen_HK
dc.subjectNIDDMen_HK
dc.titleApolipoprotein (a) levels and phenotypes in NIDDM patients with microalbuminuria and albuminuriaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0931-0509&volume=11&issue=11&spage=2229&epage=2236&date=1996&atitle=Apolipoprotein+(a)+levels+and+phenotypes+in+NIDDM+patients+with+microalbuminuria+and+albuminuriaen_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailPang, RWC: robertap@hkucc.hku.hken_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityPang, RWC=rp00274en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8941583en_HK
dc.identifier.scopuseid_2-s2.0-0029854018en_HK
dc.identifier.hkuros22863-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029854018&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue11en_HK
dc.identifier.spage2229en_HK
dc.identifier.epage2236en_HK
dc.identifier.isiWOS:A1996VT93100023-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridPang, RWC=7004376659en_HK
dc.identifier.scopusauthoridWat, MS=6603247639en_HK
dc.identifier.scopusauthoridLauder, IJ=35564928000en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK

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