Article: Changes in serum lipoprotein(a) and lipids during treatment of hyperthyroidism

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TitleChanges in serum lipoprotein(a) and lipids during treatment of hyperthyroidism
AuthorsKung, AWC1
Pang, RWC1
Lauder, I1
Lam, KSL1
Janus, ED1
KeywordsThyrotoxicosis
Radioactive iodine
Apolipoproteins
Cholesterol
Issue Date1995
PublisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
CitationClinical Chemistry, 1995, v. 41 n. 2, p. 226-231 [How to Cite?]
AbstractBecause of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes of serum Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated with radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P <0.001) concentrations of apo(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apo B, but higher apo A-I concentrations compared with age-matched controls [geometric mean (range)]; apo(a) 81 (17- 614) vs 187 (17-1808 IU/L): TC 4.07 ± 0.8 vs 5.22 ± 1.00 mmol/L (mean ± SD); LDL-C 2.47 ± 0.89 vs 3.40 ± 0.88 mmol/L; HDL-C 1.05 ± 0.33 vs 1.24 ± 0.34 mmol/L; apo B 0.66 ± 0.23 vs 1.13 ± 0.34 g/L, and apo A-I 2.07 ± 0.42 vs 1.46 ± 0.28 g/L, respectively. Euthyroidism was associated with normalization of serum TC, LDL-C, and apo B within 1 month of treatment. However, apo(a) required 4 months to normalize, and HDL-C and apo A-I were still abnormal 6 months after RAI. Serum apo(a), TC, LDL-C, and apo B were negatively correlated with serum thyroxine (T4), free thyroxine index, and triiodothyronine (T3) and positively correlated with thyrotropin during the transitional period from hyperthyroidism to euthyroidism. Parallel changes of these lipoproteins and thyroid hormones were also observed after treatment of hyperthyroidism. In conclusion, thyroid hormones do modulate lipoproteins, particularly Lp(a). The delay in normalization of apo(a) but not LDL suggests an effect on apo(a) production rather than on LDL removal.
ISSN0009-9147
2011 Impact Factor: 7.905
2011 SCImago Journal Rankings: 0.650
ISI Accession Number IDWOS:A1995QG65200012
DC Field
Value
dc.contributor.authorKung, AWC
dc.contributor.authorPang, RWC
dc.contributor.authorLauder, I
dc.contributor.authorLam, KSL
dc.contributor.authorJanus, ED
dc.date.accessioned2008-06-12T06:33:28Z
dc.date.available2008-06-12T06:33:28Z
dc.date.issued1995
dc.description.abstractBecause of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes of serum Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated with radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P <0.001) concentrations of apo(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apo B, but higher apo A-I concentrations compared with age-matched controls [geometric mean (range)]; apo(a) 81 (17- 614) vs 187 (17-1808 IU/L): TC 4.07 ± 0.8 vs 5.22 ± 1.00 mmol/L (mean ± SD); LDL-C 2.47 ± 0.89 vs 3.40 ± 0.88 mmol/L; HDL-C 1.05 ± 0.33 vs 1.24 ± 0.34 mmol/L; apo B 0.66 ± 0.23 vs 1.13 ± 0.34 g/L, and apo A-I 2.07 ± 0.42 vs 1.46 ± 0.28 g/L, respectively. Euthyroidism was associated with normalization of serum TC, LDL-C, and apo B within 1 month of treatment. However, apo(a) required 4 months to normalize, and HDL-C and apo A-I were still abnormal 6 months after RAI. Serum apo(a), TC, LDL-C, and apo B were negatively correlated with serum thyroxine (T4), free thyroxine index, and triiodothyronine (T3) and positively correlated with thyrotropin during the transitional period from hyperthyroidism to euthyroidism. Parallel changes of these lipoproteins and thyroid hormones were also observed after treatment of hyperthyroidism. In conclusion, thyroid hormones do modulate lipoproteins, particularly Lp(a). The delay in normalization of apo(a) but not LDL suggests an effect on apo(a) production rather than on LDL removal.
dc.description.naturepublished_or_final_version
dc.format.extent418 bytes
dc.format.mimetypetext/html
dc.identifier.citationClinical Chemistry, 1995, v. 41 n. 2, p. 226-231 [How to Cite?]
dc.identifier.epage231
dc.identifier.hkuros20913
dc.identifier.isiWOS:A1995QG65200012
dc.identifier.issn0009-9147
2011 Impact Factor: 7.905
2011 SCImago Journal Rankings: 0.650
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid7874776
dc.identifier.scopuseid_2-s2.0-0028908938
dc.identifier.spage226
dc.identifier.urihttp://hdl.handle.net/10722/49056
dc.identifier.volume41
dc.languageeng
dc.publisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
dc.publisher.placeUnited States
dc.relation.ispartofClinical Chemistry
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subjectThyrotoxicosis
dc.subjectRadioactive iodine
dc.subjectApolipoproteins
dc.subjectCholesterol
dc.titleChanges in serum lipoprotein(a) and lipids during treatment of hyperthyroidism
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong