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Article: Changes in serum lipoprotein(a) and lipids during treatment of hyperthyroidism
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TitleChanges in serum lipoprotein(a) and lipids during treatment of hyperthyroidism
 
AuthorsKung, AWC1
Pang, RWC1
Lauder, I1
Lam, KSL1
Janus, ED1
 
KeywordsThyrotoxicosis
Radioactive iodine
Apolipoproteins
Cholesterol
 
Issue Date1995
 
PublisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
 
CitationClinical Chemistry, 1995, v. 41 n. 2, p. 226-231 [How to Cite?]
 
AbstractBecause of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes of serum Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated with radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P <0.001) concentrations of apo(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apo B, but higher apo A-I concentrations compared with age-matched controls [geometric mean (range)]; apo(a) 81 (17- 614) vs 187 (17-1808 IU/L): TC 4.07 ± 0.8 vs 5.22 ± 1.00 mmol/L (mean ± SD); LDL-C 2.47 ± 0.89 vs 3.40 ± 0.88 mmol/L; HDL-C 1.05 ± 0.33 vs 1.24 ± 0.34 mmol/L; apo B 0.66 ± 0.23 vs 1.13 ± 0.34 g/L, and apo A-I 2.07 ± 0.42 vs 1.46 ± 0.28 g/L, respectively. Euthyroidism was associated with normalization of serum TC, LDL-C, and apo B within 1 month of treatment. However, apo(a) required 4 months to normalize, and HDL-C and apo A-I were still abnormal 6 months after RAI. Serum apo(a), TC, LDL-C, and apo B were negatively correlated with serum thyroxine (T4), free thyroxine index, and triiodothyronine (T3) and positively correlated with thyrotropin during the transitional period from hyperthyroidism to euthyroidism. Parallel changes of these lipoproteins and thyroid hormones were also observed after treatment of hyperthyroidism. In conclusion, thyroid hormones do modulate lipoproteins, particularly Lp(a). The delay in normalization of apo(a) but not LDL suggests an effect on apo(a) production rather than on LDL removal.
 
ISSN0009-9147
2012 Impact Factor: 7.149
2012 SCImago Journal Rankings: 2.093
 
ISI Accession Number IDWOS:A1995QG65200012
 
DC FieldValue
dc.contributor.authorKung, AWC
 
dc.contributor.authorPang, RWC
 
dc.contributor.authorLauder, I
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorJanus, ED
 
dc.date.accessioned2008-06-12T06:33:28Z
 
dc.date.available2008-06-12T06:33:28Z
 
dc.date.issued1995
 
dc.description.abstractBecause of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes of serum Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated with radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P <0.001) concentrations of apo(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apo B, but higher apo A-I concentrations compared with age-matched controls [geometric mean (range)]; apo(a) 81 (17- 614) vs 187 (17-1808 IU/L): TC 4.07 ± 0.8 vs 5.22 ± 1.00 mmol/L (mean ± SD); LDL-C 2.47 ± 0.89 vs 3.40 ± 0.88 mmol/L; HDL-C 1.05 ± 0.33 vs 1.24 ± 0.34 mmol/L; apo B 0.66 ± 0.23 vs 1.13 ± 0.34 g/L, and apo A-I 2.07 ± 0.42 vs 1.46 ± 0.28 g/L, respectively. Euthyroidism was associated with normalization of serum TC, LDL-C, and apo B within 1 month of treatment. However, apo(a) required 4 months to normalize, and HDL-C and apo A-I were still abnormal 6 months after RAI. Serum apo(a), TC, LDL-C, and apo B were negatively correlated with serum thyroxine (T4), free thyroxine index, and triiodothyronine (T3) and positively correlated with thyrotropin during the transitional period from hyperthyroidism to euthyroidism. Parallel changes of these lipoproteins and thyroid hormones were also observed after treatment of hyperthyroidism. In conclusion, thyroid hormones do modulate lipoproteins, particularly Lp(a). The delay in normalization of apo(a) but not LDL suggests an effect on apo(a) production rather than on LDL removal.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent418 bytes
 
dc.format.mimetypetext/html
 
dc.identifier.citationClinical Chemistry, 1995, v. 41 n. 2, p. 226-231 [How to Cite?]
 
dc.identifier.epage231
 
dc.identifier.hkuros20913
 
dc.identifier.isiWOS:A1995QG65200012
 
dc.identifier.issn0009-9147
2012 Impact Factor: 7.149
2012 SCImago Journal Rankings: 2.093
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid7874776
 
dc.identifier.scopuseid_2-s2.0-0028908938
 
dc.identifier.spage226
 
dc.identifier.urihttp://hdl.handle.net/10722/49056
 
dc.identifier.volume41
 
dc.languageeng
 
dc.publisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofClinical Chemistry
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectThyrotoxicosis
 
dc.subjectRadioactive iodine
 
dc.subjectApolipoproteins
 
dc.subjectCholesterol
 
dc.titleChanges in serum lipoprotein(a) and lipids during treatment of hyperthyroidism
 
dc.typeArticle
 
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<contributor.author>Lauder, I</contributor.author>
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<contributor.author>Janus, ED</contributor.author>
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<description.abstract>Because of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes of serum Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated with radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P &lt;0.001) concentrations of apo(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apo B, but higher apo A-I concentrations compared with age-matched controls [geometric mean (range)]; apo(a) 81 (17- 614) vs 187 (17-1808 IU/L): TC 4.07 &#177; 0.8 vs 5.22 &#177; 1.00 mmol/L (mean &#177; SD); LDL-C 2.47 &#177; 0.89 vs 3.40 &#177; 0.88 mmol/L; HDL-C 1.05 &#177; 0.33 vs 1.24 &#177; 0.34 mmol/L; apo B 0.66 &#177; 0.23 vs 1.13 &#177; 0.34 g/L, and apo A-I 2.07 &#177; 0.42 vs 1.46 &#177; 0.28 g/L, respectively. Euthyroidism was associated with normalization of serum TC, LDL-C, and apo B within 1 month of treatment. However, apo(a) required 4 months to normalize, and HDL-C and apo A-I were still abnormal 6 months after RAI. Serum apo(a), TC, LDL-C, and apo B were negatively correlated with serum thyroxine (T4), free thyroxine index, and triiodothyronine (T3) and positively correlated with thyrotropin during the transitional period from hyperthyroidism to euthyroidism. Parallel changes of these lipoproteins and thyroid hormones were also observed after treatment of hyperthyroidism. In conclusion, thyroid hormones do modulate lipoproteins, particularly Lp(a). The delay in normalization of apo(a) but not LDL suggests an effect on apo(a) production rather than on LDL removal.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong