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Article: Changes in serum lipoprotein(a) and lipids during treatment of hyperthyroidism

TitleChanges in serum lipoprotein(a) and lipids during treatment of hyperthyroidism
Authors
KeywordsThyrotoxicosis
Radioactive iodine
Apolipoproteins
Cholesterol
Issue Date1995
PublisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.org
Citation
Clinical Chemistry, 1995, v. 41 n. 2, p. 226-231 How to Cite?
Abstract
Because of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes of serum Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated with radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P <0.001) concentrations of apo(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apo B, but higher apo A-I concentrations compared with age-matched controls [geometric mean (range)]; apo(a) 81 (17- 614) vs 187 (17-1808 IU/L): TC 4.07 ± 0.8 vs 5.22 ± 1.00 mmol/L (mean ± SD); LDL-C 2.47 ± 0.89 vs 3.40 ± 0.88 mmol/L; HDL-C 1.05 ± 0.33 vs 1.24 ± 0.34 mmol/L; apo B 0.66 ± 0.23 vs 1.13 ± 0.34 g/L, and apo A-I 2.07 ± 0.42 vs 1.46 ± 0.28 g/L, respectively. Euthyroidism was associated with normalization of serum TC, LDL-C, and apo B within 1 month of treatment. However, apo(a) required 4 months to normalize, and HDL-C and apo A-I were still abnormal 6 months after RAI. Serum apo(a), TC, LDL-C, and apo B were negatively correlated with serum thyroxine (T4), free thyroxine index, and triiodothyronine (T3) and positively correlated with thyrotropin during the transitional period from hyperthyroidism to euthyroidism. Parallel changes of these lipoproteins and thyroid hormones were also observed after treatment of hyperthyroidism. In conclusion, thyroid hormones do modulate lipoproteins, particularly Lp(a). The delay in normalization of apo(a) but not LDL suggests an effect on apo(a) production rather than on LDL removal.
Persistent Identifierhttp://hdl.handle.net/10722/49056
ISSN
2013 Impact Factor: 7.768
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorPang, RWCen_HK
dc.contributor.authorLauder, Ien_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorJanus, EDen_HK
dc.date.accessioned2008-06-12T06:33:28Z-
dc.date.available2008-06-12T06:33:28Z-
dc.date.issued1995en_HK
dc.identifier.citationClinical Chemistry, 1995, v. 41 n. 2, p. 226-231en_HK
dc.identifier.issn0009-9147en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49056-
dc.description.abstractBecause of suggestions that thyroid hormones modulate serum lipoprotein(a) [Lp(a)] concentration, we evaluated prospectively the serial changes of serum Lp(a), measured as apolipoprotein(a) [apo(a)], and other lipoproteins in 40 subjects with hyperthyroidism treated with radioactive iodine (RAI) therapy. Hyperthyroid patients had lower (P <0.001) concentrations of apo(a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and apo B, but higher apo A-I concentrations compared with age-matched controls [geometric mean (range)]; apo(a) 81 (17- 614) vs 187 (17-1808 IU/L): TC 4.07 ± 0.8 vs 5.22 ± 1.00 mmol/L (mean ± SD); LDL-C 2.47 ± 0.89 vs 3.40 ± 0.88 mmol/L; HDL-C 1.05 ± 0.33 vs 1.24 ± 0.34 mmol/L; apo B 0.66 ± 0.23 vs 1.13 ± 0.34 g/L, and apo A-I 2.07 ± 0.42 vs 1.46 ± 0.28 g/L, respectively. Euthyroidism was associated with normalization of serum TC, LDL-C, and apo B within 1 month of treatment. However, apo(a) required 4 months to normalize, and HDL-C and apo A-I were still abnormal 6 months after RAI. Serum apo(a), TC, LDL-C, and apo B were negatively correlated with serum thyroxine (T4), free thyroxine index, and triiodothyronine (T3) and positively correlated with thyrotropin during the transitional period from hyperthyroidism to euthyroidism. Parallel changes of these lipoproteins and thyroid hormones were also observed after treatment of hyperthyroidism. In conclusion, thyroid hormones do modulate lipoproteins, particularly Lp(a). The delay in normalization of apo(a) but not LDL suggests an effect on apo(a) production rather than on LDL removal.en_HK
dc.format.extent418 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherAmerican Association for Clinical Chemistry, Inc. The Journal's web site is located at http://www.clinchem.orgen_HK
dc.relation.ispartofClinical Chemistryen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectThyrotoxicosisen_HK
dc.subjectRadioactive iodineen_HK
dc.subjectApolipoproteinsen_HK
dc.subjectCholesterolen_HK
dc.titleChanges in serum lipoprotein(a) and lipids during treatment of hyperthyroidismen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-9147&volume=41&issue=2&spage=226&epage=231&date=1995&atitle=Changes+in+serum+lipoprotein(a)+and+lipids+during+treatment+of+hyperthyroidismen_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.emailPang, RWC: robertap@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.authorityPang, RWC=rp00274en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid7874776en_HK
dc.identifier.scopuseid_2-s2.0-0028908938en_HK
dc.identifier.hkuros20913-
dc.identifier.volume41en_HK
dc.identifier.issue2en_HK
dc.identifier.spage226en_HK
dc.identifier.epage231en_HK
dc.identifier.isiWOS:A1995QG65200012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.scopusauthoridPang, RWC=7004376659en_HK
dc.identifier.scopusauthoridLauder, I=35564928000en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK

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