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Article: An evaluation of whole blood testing for Helicobacter pylori infection in the Chinese population

TitleAn evaluation of whole blood testing for Helicobacter pylori infection in the Chinese population
Authors
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2000, v. 14 n. 3, p. 331-335 How to Cite?
AbstractBackground: Near patient tests for Helicobacter pylori were developed to assist in the management of dyspepsia patients in general practice. Most studies were performed in western populations. Aim: To evaluate the rapid whole blood test (Flexpack HP) for H. pylori in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During upper endoscopy, biopsies were taken from the antrum and corpus for rapid urease test (CLO test) and histological examination. After endoscopy, the whole blood test (FlexPack HP) was performed according to the manufacturer's instruction. Patients then received a 13C-urea breath test. Results of the whole blood test were compared with the gold standard (CLO test, histology and 13C-urea breath test). Results: A total of 294 consecutive patients gave a valid Flexpack HP result for interpretation. The mean age of patients was 47.7 (range 15-85) years. Analysis showed a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 58%, 92%, 91%, 63% and 73% respectively. Conclusion: The FlexPack HP whole blood test showed good specificity but lacked sensitivity. It is not sensitive enough to be used in a general practice setting for the test-and-treat approach in the Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/48625
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorTang, VSYen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorHu, WHCen_HK
dc.contributor.authorChan, CKen_HK
dc.contributor.authorLau, GKKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2008-05-22T04:19:23Z-
dc.date.available2008-05-22T04:19:23Z-
dc.date.issued2000en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 3, p. 331-335en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48625-
dc.description.abstractBackground: Near patient tests for Helicobacter pylori were developed to assist in the management of dyspepsia patients in general practice. Most studies were performed in western populations. Aim: To evaluate the rapid whole blood test (Flexpack HP) for H. pylori in the Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. During upper endoscopy, biopsies were taken from the antrum and corpus for rapid urease test (CLO test) and histological examination. After endoscopy, the whole blood test (FlexPack HP) was performed according to the manufacturer's instruction. Patients then received a 13C-urea breath test. Results of the whole blood test were compared with the gold standard (CLO test, histology and 13C-urea breath test). Results: A total of 294 consecutive patients gave a valid Flexpack HP result for interpretation. The mean age of patients was 47.7 (range 15-85) years. Analysis showed a sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 58%, 92%, 91%, 63% and 73% respectively. Conclusion: The FlexPack HP whole blood test showed good specificity but lacked sensitivity. It is not sensitive enough to be used in a general practice setting for the test-and-treat approach in the Chinese population.en_HK
dc.format.extent47214 bytes-
dc.format.extent244752 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/pdf-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.en_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_HK
dc.subject.meshHelicobacter pylorien_HK
dc.subject.meshHelicobacter Infections - blood - diagnosis - microbiologyen_HK
dc.subject.meshEndoscopy, Gastrointestinalen_HK
dc.titleAn evaluation of whole blood testing for Helicobacter pylori infection in the Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-2813&volume=14&issue=3&spage=331&epage=5&date=2000&atitle=An+evaluation+of+whole+blood+testing+for+Helicobacter+pylori+infection+in+Chinese+populationen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1046/j.1365-2036.2000.00704.xen_HK
dc.identifier.pmid10735927-
dc.identifier.scopuseid_2-s2.0-0034018404en_HK
dc.identifier.hkuros50518-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034018404&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue3en_HK
dc.identifier.spage331en_HK
dc.identifier.epage335en_HK
dc.identifier.isiWOS:000086010900011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridTang, VSY=6701711948en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridHu, WHC=25932937100en_HK
dc.identifier.scopusauthoridChan, CK=7404813824en_HK
dc.identifier.scopusauthoridLau, GKK=7102301257en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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