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Article: Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17
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TitleAssociation of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17
 
AuthorsCheung, BMY1
Leung, RYH1
Man, YB1
Ong, KL1
Wong, LYF1
Lau, CP1
Lam, KSL1
 
KeywordsBlood pressure
Genotype
Haplotype
Metabolic syndrome
Single nucleotide polymorphism
 
Issue Date2006
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
CitationJournal Of Human Hypertension, 2006, v. 20 n. 6, p. 419-425 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.jhh.1002003
 
AbstractGenome scan in Chinese revealed an association of blood pressure with the microsatellite marker D17S1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17. We previously reported that D17S1303 was associated with hypertension and obesity. Therefore, we studied 10 single nucleotide polymorphisms (SNP) within 3 kb of D17S1303. One hundred and eighty hypertensive subjects (91 men, 89 women, age 53 ± 12 years) and 180 normotensive matched controls (91 men, 89 women, age 52 ± 11) were genotyped using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852319) were homozygous in our subjects. The genotype frequencies of rs852320, rs852321 and rs852322 did not differ between hypertensive and normotensive subjects. However, there were significant differences for rs1525402 (P = 0.048), rs2692343 (P = 0.022), rs2692344 (P = 0.017) and rs2321313 (P = 0.028). A four-locus haplotype comprising G at rs1525402, C at rs2692343, C at rs2692344 and G at rs2321313 was associated with lower systolic blood pressure (P = 0.023) and normotension (P = 0.048). Our results provide further evidence that there is a gene, as yet unidentified, influencing blood pressure in the vicinity of D17S1303 in a quantitative trait locus for abdominal obesity-metabolic syndrome at 17p12. © 2006 Nature Publishing Group. All rights reserved.
 
ISSN0950-9240
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.177
 
DOIhttp://dx.doi.org/10.1038/sj.jhh.1002003
 
ISI Accession Number IDWOS:000237673500006
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorMan, YB
 
dc.contributor.authorOng, KL
 
dc.contributor.authorWong, LYF
 
dc.contributor.authorLau, CP
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2008-05-22T04:19:13Z
 
dc.date.available2008-05-22T04:19:13Z
 
dc.date.issued2006
 
dc.description.abstractGenome scan in Chinese revealed an association of blood pressure with the microsatellite marker D17S1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17. We previously reported that D17S1303 was associated with hypertension and obesity. Therefore, we studied 10 single nucleotide polymorphisms (SNP) within 3 kb of D17S1303. One hundred and eighty hypertensive subjects (91 men, 89 women, age 53 ± 12 years) and 180 normotensive matched controls (91 men, 89 women, age 52 ± 11) were genotyped using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852319) were homozygous in our subjects. The genotype frequencies of rs852320, rs852321 and rs852322 did not differ between hypertensive and normotensive subjects. However, there were significant differences for rs1525402 (P = 0.048), rs2692343 (P = 0.022), rs2692344 (P = 0.017) and rs2321313 (P = 0.028). A four-locus haplotype comprising G at rs1525402, C at rs2692343, C at rs2692344 and G at rs2321313 was associated with lower systolic blood pressure (P = 0.023) and normotension (P = 0.048). Our results provide further evidence that there is a gene, as yet unidentified, influencing blood pressure in the vicinity of D17S1303 in a quantitative trait locus for abdominal obesity-metabolic syndrome at 17p12. © 2006 Nature Publishing Group. All rights reserved.
 
dc.description.naturepostprint
 
dc.format.extent158720 bytes
 
dc.format.extent3408 bytes
 
dc.format.mimetypeapplication/pdf
 
dc.format.mimetypetext/plain
 
dc.identifier.citationJournal Of Human Hypertension, 2006, v. 20 n. 6, p. 419-425 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.jhh.1002003
 
dc.identifier.citeulike526414
 
dc.identifier.doihttp://dx.doi.org/10.1038/sj.jhh.1002003
 
dc.identifier.epage425
 
dc.identifier.isiWOS:000237673500006
 
dc.identifier.issn0950-9240
2013 Impact Factor: 2.692
2013 SCImago Journal Rankings: 1.177
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid16511504
 
dc.identifier.scopuseid_2-s2.0-33646855264
 
dc.identifier.spage419
 
dc.identifier.urihttp://hdl.handle.net/10722/48619
 
dc.identifier.volume20
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Human Hypertension
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subjectBlood pressure
 
dc.subjectGenotype
 
dc.subjectHaplotype
 
dc.subjectMetabolic syndrome
 
dc.subjectSingle nucleotide polymorphism
 
dc.titleAssociation of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong