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Article: Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17

TitleAssociation of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17
Authors
KeywordsBlood pressure
Genotype
Haplotype
Metabolic syndrome
Single nucleotide polymorphism
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
Citation
Journal Of Human Hypertension, 2006, v. 20 n. 6, p. 419-425 How to Cite?
AbstractGenome scan in Chinese revealed an association of blood pressure with the microsatellite marker D17S1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17. We previously reported that D17S1303 was associated with hypertension and obesity. Therefore, we studied 10 single nucleotide polymorphisms (SNP) within 3 kb of D17S1303. One hundred and eighty hypertensive subjects (91 men, 89 women, age 53 ± 12 years) and 180 normotensive matched controls (91 men, 89 women, age 52 ± 11) were genotyped using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852319) were homozygous in our subjects. The genotype frequencies of rs852320, rs852321 and rs852322 did not differ between hypertensive and normotensive subjects. However, there were significant differences for rs1525402 (P = 0.048), rs2692343 (P = 0.022), rs2692344 (P = 0.017) and rs2321313 (P = 0.028). A four-locus haplotype comprising G at rs1525402, C at rs2692343, C at rs2692344 and G at rs2321313 was associated with lower systolic blood pressure (P = 0.023) and normotension (P = 0.048). Our results provide further evidence that there is a gene, as yet unidentified, influencing blood pressure in the vicinity of D17S1303 in a quantitative trait locus for abdominal obesity-metabolic syndrome at 17p12. © 2006 Nature Publishing Group. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/48619
ISSN
2014 Impact Factor: 2.700
2014 SCImago Journal Rankings: 0.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorMan, YBen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorWong, LYFen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2008-05-22T04:19:13Z-
dc.date.available2008-05-22T04:19:13Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Human Hypertension, 2006, v. 20 n. 6, p. 419-425en_HK
dc.identifier.issn0950-9240en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48619-
dc.description.abstractGenome scan in Chinese revealed an association of blood pressure with the microsatellite marker D17S1303, which lies in a quantitative trait locus for the abdominal obesity-metabolic syndrome (AOMS2) at 17p12 on chromosome 17. We previously reported that D17S1303 was associated with hypertension and obesity. Therefore, we studied 10 single nucleotide polymorphisms (SNP) within 3 kb of D17S1303. One hundred and eighty hypertensive subjects (91 men, 89 women, age 53 ± 12 years) and 180 normotensive matched controls (91 men, 89 women, age 52 ± 11) were genotyped using the Sequenom genotyping platform. Allelic frequencies in these Chinese subjects differed from those reported for Caucasians. Three SNPs (rs11656507, rs1357926, rs852319) were homozygous in our subjects. The genotype frequencies of rs852320, rs852321 and rs852322 did not differ between hypertensive and normotensive subjects. However, there were significant differences for rs1525402 (P = 0.048), rs2692343 (P = 0.022), rs2692344 (P = 0.017) and rs2321313 (P = 0.028). A four-locus haplotype comprising G at rs1525402, C at rs2692343, C at rs2692344 and G at rs2321313 was associated with lower systolic blood pressure (P = 0.023) and normotension (P = 0.048). Our results provide further evidence that there is a gene, as yet unidentified, influencing blood pressure in the vicinity of D17S1303 in a quantitative trait locus for abdominal obesity-metabolic syndrome at 17p12. © 2006 Nature Publishing Group. All rights reserved.en_HK
dc.format.extent158720 bytes-
dc.format.extent3408 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhhen_HK
dc.relation.ispartofJournal of Human Hypertensionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectBlood pressureen_HK
dc.subjectGenotypeen_HK
dc.subjectHaplotypeen_HK
dc.subjectMetabolic syndromeen_HK
dc.subjectSingle nucleotide polymorphismen_HK
dc.titleAssociation of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0950-9240&volume=20&issue=6&spage=419&epage=425&date=2006&atitle=Association+of+hypertension+with+single+nucleotide+polymorphisms+in+the+quantitative+trait+locus+for+abdominal+obesity-metabolic+syndrome+on+chromosome+17en_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturepostprinten_HK
dc.identifier.doi10.1038/sj.jhh.1002003en_HK
dc.identifier.pmid16511504en_HK
dc.identifier.scopuseid_2-s2.0-33646855264en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646855264&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue6en_HK
dc.identifier.spage419en_HK
dc.identifier.epage425en_HK
dc.identifier.isiWOS:000237673500006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridMan, YB=10245005900en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.citeulike526414-

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