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Article: Hepatic resection for colorectal liver metastases: prospective study.
Title | Hepatic resection for colorectal liver metastases: prospective study. |
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Authors | |
Issue Date | 2002 |
Publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html |
Citation | Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2002, v. 8 n. 5, p. 329-333 How to Cite? |
Abstract | OBJECTIVE: To assess the operative and long-term survival outcomes of hepatic resection for colorectal liver metastases during an 11-year period in a tertiary referral centre in Hong Kong. DESIGN: Prospective study. SETTING: University teaching hospital, Hong Kong. SUBJECTS AND METHODS: Between January 1989 and December 1999, 72 patients underwent hepatic resection for colorectal liver metastases. Clinical, pathological, and outcome data were prospectively collected and analysed. Factors affecting long-term survival were also evaluated. RESULTS: Twenty-five (34.7%) patients were found to have synchronous hepatic metastasis at the time of colorectal resection. Fifty-two (72.2%) patients underwent major hepatic resection. The operative morbidity and hospital mortality rates were 19% and 4%, respectively. The 5-year survival rate after hepatectomy was 31.9%. The median disease-free survival and median overall cumulative survival were 18.5 months and 30.8 months, respectively. On multivariate analysis, a high preoperative serum carcinoembryonic antigen level (>200 ng/mL) and tumour involvement of the resection margin at histology were the two independent risk factors that adversely affected survival outcome. CONCLUSION: Hepatic resection for colorectal liver metastases can be performed safely, with minimal operative mortality and acceptable morbidity, and results in satisfactory survival. High preoperative serum carcinoembryonic antigen level and histological involvement of resection margin by cancer adversely affect the survival outcome. |
Persistent Identifier | http://hdl.handle.net/10722/48480 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
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dc.contributor.author | Liu, CL | en_HK |
dc.contributor.author | Fan, ST | en_HK |
dc.contributor.author | Lo, CM | en_HK |
dc.contributor.author | Law, WL | en_HK |
dc.contributor.author | Ng, IO | en_HK |
dc.contributor.author | Wong, J | en_HK |
dc.date.accessioned | 2008-05-22T04:14:30Z | - |
dc.date.available | 2008-05-22T04:14:30Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2002, v. 8 n. 5, p. 329-333 | en_HK |
dc.identifier.issn | 1024-2708 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/48480 | - |
dc.description.abstract | OBJECTIVE: To assess the operative and long-term survival outcomes of hepatic resection for colorectal liver metastases during an 11-year period in a tertiary referral centre in Hong Kong. DESIGN: Prospective study. SETTING: University teaching hospital, Hong Kong. SUBJECTS AND METHODS: Between January 1989 and December 1999, 72 patients underwent hepatic resection for colorectal liver metastases. Clinical, pathological, and outcome data were prospectively collected and analysed. Factors affecting long-term survival were also evaluated. RESULTS: Twenty-five (34.7%) patients were found to have synchronous hepatic metastasis at the time of colorectal resection. Fifty-two (72.2%) patients underwent major hepatic resection. The operative morbidity and hospital mortality rates were 19% and 4%, respectively. The 5-year survival rate after hepatectomy was 31.9%. The median disease-free survival and median overall cumulative survival were 18.5 months and 30.8 months, respectively. On multivariate analysis, a high preoperative serum carcinoembryonic antigen level (>200 ng/mL) and tumour involvement of the resection margin at histology were the two independent risk factors that adversely affected survival outcome. CONCLUSION: Hepatic resection for colorectal liver metastases can be performed safely, with minimal operative mortality and acceptable morbidity, and results in satisfactory survival. High preoperative serum carcinoembryonic antigen level and histological involvement of resection margin by cancer adversely affect the survival outcome. | en_HK |
dc.format.extent | 265662 bytes | - |
dc.format.extent | 35328 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/msword | - |
dc.language | eng | en_HK |
dc.publisher | Hong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html | en_HK |
dc.relation.ispartof | Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine | en_HK |
dc.rights | Hong Kong Medical Journal. Copyright © Hong Kong Medical Association. | en_HK |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.mesh | Carcinoma - secondary - surgery | en_HK |
dc.subject.mesh | Colorectal Neoplasms - pathology | en_HK |
dc.subject.mesh | Hepatectomy | en_HK |
dc.subject.mesh | Liver Neoplasms - blood - secondary - surgery | en_HK |
dc.subject.mesh | Disease-Free Survival | en_HK |
dc.title | Hepatic resection for colorectal liver metastases: prospective study. | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1024-2708&volume=8&issue=5&spage=329&epage=333&date=2002&atitle=Hepatic+resection+for+colorectal+liver+metastases:+prospective+study | en_HK |
dc.identifier.email | Fan, ST: stfan@hku.hk | en_HK |
dc.identifier.email | Lo, CM: chungmlo@hkucc.hku.hk | en_HK |
dc.identifier.email | Law, WL: lawwl@hkucc.hku.hk | en_HK |
dc.identifier.email | Ng, IO: iolng@hku.hk | en_HK |
dc.identifier.email | Wong, J: jwong@hkucc.hku.hk | en_HK |
dc.identifier.authority | Fan, ST=rp00355 | en_HK |
dc.identifier.authority | Lo, CM=rp00412 | en_HK |
dc.identifier.authority | Law, WL=rp00436 | en_HK |
dc.identifier.authority | Ng, IO=rp00335 | en_HK |
dc.identifier.authority | Wong, J=rp00322 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.pmid | 12376709 | - |
dc.identifier.scopus | eid_2-s2.0-0036781990 | en_HK |
dc.identifier.hkuros | 77108 | - |
dc.identifier.volume | 8 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 329 | en_HK |
dc.identifier.epage | 333 | en_HK |
dc.publisher.place | Hong Kong | en_HK |
dc.identifier.scopusauthorid | Liu, CL=7409789712 | en_HK |
dc.identifier.scopusauthorid | Fan, ST=7402678224 | en_HK |
dc.identifier.scopusauthorid | Lo, CM=7401771672 | en_HK |
dc.identifier.scopusauthorid | Law, WL=7103147867 | en_HK |
dc.identifier.scopusauthorid | Ng, IO=7102753722 | en_HK |
dc.identifier.scopusauthorid | Wong, J=8049324500 | en_HK |
dc.identifier.issnl | 1024-2708 | - |