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Article: Expression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta

TitleExpression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta
Authors
Issue Date1993
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1993, v. 46 n. 3, p. 204-207 How to Cite?
AbstractAims: To compare the expression of c-myc and c-fms proto-oncogenes in the placenta and hydatidiform mole. Methods: Twelve hydatidiform moles and six induced abortion cases were collected. c-myc and c-fms proto-oncogene expression was analysed by northern blot hybridisation and immunohistochemical staining. Results: The results of northern blot hybridisation analysis showed that c-fms was expressed more strongly in hydatidiform moles compared with normal placenta of similar gestational age. Moreover, c-fms mRNA concentrations increased with more advanced gestational age in moles but not in normal placentas. c-myc expression was very low in hydatidiform moles and normal placentas. Both oncogenes, however, had no direct correlation with the clinical course of the molar pregnancies. Conclusion: The difference in c-fms expression between hydatidiform moles and normal placentas suggests that c-fms may have a role in the development of molar pregnancies.
Persistent Identifierhttp://hdl.handle.net/10722/45490
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorPittaluga, Sen_HK
dc.contributor.authorMan, TKen_HK
dc.contributor.authorNgan, Hen_HK
dc.contributor.authorCollins, RJen_HK
dc.date.accessioned2007-10-30T06:27:14Z-
dc.date.available2007-10-30T06:27:14Z-
dc.date.issued1993en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1993, v. 46 n. 3, p. 204-207en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45490-
dc.description.abstractAims: To compare the expression of c-myc and c-fms proto-oncogenes in the placenta and hydatidiform mole. Methods: Twelve hydatidiform moles and six induced abortion cases were collected. c-myc and c-fms proto-oncogene expression was analysed by northern blot hybridisation and immunohistochemical staining. Results: The results of northern blot hybridisation analysis showed that c-fms was expressed more strongly in hydatidiform moles compared with normal placenta of similar gestational age. Moreover, c-fms mRNA concentrations increased with more advanced gestational age in moles but not in normal placentas. c-myc expression was very low in hydatidiform moles and normal placentas. Both oncogenes, however, had no direct correlation with the clinical course of the molar pregnancies. Conclusion: The difference in c-fms expression between hydatidiform moles and normal placentas suggests that c-fms may have a role in the development of molar pregnancies.en_HK
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dc.format.extent2817 bytes-
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dc.format.extent3017 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
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dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshHydatidiform-Mole-chemistryen_HK
dc.subject.meshPlacenta-chemistryen_HK
dc.subject.meshProto-Oncogene-Proteins-c-myc-analysisen_HK
dc.subject.meshReceptor,-Macrophage-Colony-Stimulating-Factor-analysisen_HK
dc.subject.meshTrophoblasts-chemistryen_HK
dc.titleExpression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placentaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=46&issue=3&spage=204&epage=207&date=1993&atitle=Expression+of+c-myc+and+c-fms+oncogenes+in+trophoblastic+cells+in+hydatidiform+mole+and+normal+human+placentaen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailNgan, H:hysngan@hkucc.hku.hken_HK
dc.identifier.emailCollins, RJ:rcollins@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityNgan, H=rp00346en_HK
dc.identifier.authorityCollins, RJ=rp00251en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8463412-
dc.identifier.pmcidPMC501170-
dc.identifier.scopuseid_2-s2.0-0027414770en_HK
dc.identifier.volume46en_HK
dc.identifier.issue3en_HK
dc.identifier.spage204en_HK
dc.identifier.epage207en_HK
dc.identifier.isiWOS:A1993KQ50700003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridPittaluga, S=7006897513en_HK
dc.identifier.scopusauthoridMan, TK=36865477200en_HK
dc.identifier.scopusauthoridNgan, H=34571944100en_HK
dc.identifier.scopusauthoridCollins, RJ=7403350455en_HK

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