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Article: Central and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: Implications or aortic root dilatation
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TitleCentral and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: Implications or aortic root dilatation
 
AuthorsCheung, YF1
Ou, X1
Wong, SJ1
 
Issue Date2006
 
PublisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
 
CitationHeart, 2006, v. 92 n. 12, p. 1827-1830 [How to Cite?]
DOI: http://dx.doi.org/10.1136/hrt.2006.091199
 
AbstractObjectives: To test the hypotheses that (1) the central conduit arteries stiffen preferentially over the peripheral conduit arteries in patients with repaired tetralogy of Fallot (ToF); and (2) central arterial stiffening is related to aortic root dilatation. Design and patients: Heart-femoral pulse wave velocity (PWV), femoral-ankle PWV, carotid augmentation index and body surface area-adjusted aortic sinotubular dimension were determined in 31 children after ToF repair and compared with those in 31 age-matched controls after left-to-right shunt repair. In addition, the PWVs and augmentation index were related to the sinotubular junction dimension. Settings: Tertiary paediatric cardiac centre. Results: Compared with controls, patients had significantly greater heart-femoral PWV (mean 666 (SD 151) v 587 (81) cm/s, p = 0.021) and carotid augmentation index (-14.1 (17.0)% v -25.2 (14.6)%, p = 0.016), whereas the right (888 (202) v 845 (207) cm/s, p = 0.42) and left (918 (227) v 851 (215) cm/s, p = 0.25) femoral-ankle PWVs were similar between the two groups. The sinotubular junction z score of patients was significantly greater than that of controls (4.7 (1.5) v 1.1 (1.4), p < 0.001). Univariate analysis showed that the sinotubular junction z score correlated positively with heart-femoral PWV (r = 0.43, p = 0.001) and carotid augmentation index (r = 0.46, p = 0.001). Multiple linear regression similarly identified heart-femoral PWV (β = 0.30, p = 0.04) and carotid augmentation index (β = 0.31, p = 0.04) (model R 2 = 0.26) as significant determinants of sinotubular junction z score. Conclusions: The aorta stiffens in patients with repaired ToF, which may contribute to progressive dilatation of the aortic root in the long term.
 
ISSN1355-6037
2012 Impact Factor: 5.014
2012 SCImago Journal Rankings: 2.052
 
DOIhttp://dx.doi.org/10.1136/hrt.2006.091199
 
PubMed Central IDPMC1861289
 
ISI Accession Number IDWOS:000242048200023
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, YF
 
dc.contributor.authorOu, X
 
dc.contributor.authorWong, SJ
 
dc.date.accessioned2007-10-30T06:20:06Z
 
dc.date.available2007-10-30T06:20:06Z
 
dc.date.issued2006
 
dc.description.abstractObjectives: To test the hypotheses that (1) the central conduit arteries stiffen preferentially over the peripheral conduit arteries in patients with repaired tetralogy of Fallot (ToF); and (2) central arterial stiffening is related to aortic root dilatation. Design and patients: Heart-femoral pulse wave velocity (PWV), femoral-ankle PWV, carotid augmentation index and body surface area-adjusted aortic sinotubular dimension were determined in 31 children after ToF repair and compared with those in 31 age-matched controls after left-to-right shunt repair. In addition, the PWVs and augmentation index were related to the sinotubular junction dimension. Settings: Tertiary paediatric cardiac centre. Results: Compared with controls, patients had significantly greater heart-femoral PWV (mean 666 (SD 151) v 587 (81) cm/s, p = 0.021) and carotid augmentation index (-14.1 (17.0)% v -25.2 (14.6)%, p = 0.016), whereas the right (888 (202) v 845 (207) cm/s, p = 0.42) and left (918 (227) v 851 (215) cm/s, p = 0.25) femoral-ankle PWVs were similar between the two groups. The sinotubular junction z score of patients was significantly greater than that of controls (4.7 (1.5) v 1.1 (1.4), p < 0.001). Univariate analysis showed that the sinotubular junction z score correlated positively with heart-femoral PWV (r = 0.43, p = 0.001) and carotid augmentation index (r = 0.46, p = 0.001). Multiple linear regression similarly identified heart-femoral PWV (β = 0.30, p = 0.04) and carotid augmentation index (β = 0.31, p = 0.04) (model R 2 = 0.26) as significant determinants of sinotubular junction z score. Conclusions: The aorta stiffens in patients with repaired ToF, which may contribute to progressive dilatation of the aortic root in the long term.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent163242 bytes
 
dc.format.extent2258 bytes
 
dc.format.mimetypeapplication/pdf
 
dc.format.mimetypetext/plain
 
dc.identifier.citationHeart, 2006, v. 92 n. 12, p. 1827-1830 [How to Cite?]
DOI: http://dx.doi.org/10.1136/hrt.2006.091199
 
dc.identifier.doihttp://dx.doi.org/10.1136/hrt.2006.091199
 
dc.identifier.epage1830
 
dc.identifier.isiWOS:000242048200023
 
dc.identifier.issn1355-6037
2012 Impact Factor: 5.014
2012 SCImago Journal Rankings: 2.052
 
dc.identifier.issue12
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1861289
 
dc.identifier.pmid16775086
 
dc.identifier.scopuseid_2-s2.0-33845226445
 
dc.identifier.spage1827
 
dc.identifier.urihttp://hdl.handle.net/10722/45216
 
dc.identifier.volume92
 
dc.languageeng
 
dc.publisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHeart
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHeart. Copyright © B M J Publishing Group.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAortic Diseases - physiopathology
 
dc.subject.meshTetralogy of Fallot - physiopathology - surgery
 
dc.subject.meshBlood Flow Velocity - physiology
 
dc.subject.meshDilatation, Pathologic - physiopathology
 
dc.subject.meshVascular Resistance - physiology
 
dc.titleCentral and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: Implications or aortic root dilatation
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong