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Article: Central and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: Implications or aortic root dilatation

TitleCentral and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: Implications or aortic root dilatation
Authors
Issue Date2006
PublisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2006, v. 92 n. 12, p. 1827-1830 How to Cite?
AbstractObjectives: To test the hypotheses that (1) the central conduit arteries stiffen preferentially over the peripheral conduit arteries in patients with repaired tetralogy of Fallot (ToF); and (2) central arterial stiffening is related to aortic root dilatation. Design and patients: Heart-femoral pulse wave velocity (PWV), femoral-ankle PWV, carotid augmentation index and body surface area-adjusted aortic sinotubular dimension were determined in 31 children after ToF repair and compared with those in 31 age-matched controls after left-to-right shunt repair. In addition, the PWVs and augmentation index were related to the sinotubular junction dimension. Settings: Tertiary paediatric cardiac centre. Results: Compared with controls, patients had significantly greater heart-femoral PWV (mean 666 (SD 151) v 587 (81) cm/s, p = 0.021) and carotid augmentation index (-14.1 (17.0)% v -25.2 (14.6)%, p = 0.016), whereas the right (888 (202) v 845 (207) cm/s, p = 0.42) and left (918 (227) v 851 (215) cm/s, p = 0.25) femoral-ankle PWVs were similar between the two groups. The sinotubular junction z score of patients was significantly greater than that of controls (4.7 (1.5) v 1.1 (1.4), p < 0.001). Univariate analysis showed that the sinotubular junction z score correlated positively with heart-femoral PWV (r = 0.43, p = 0.001) and carotid augmentation index (r = 0.46, p = 0.001). Multiple linear regression similarly identified heart-femoral PWV (β = 0.30, p = 0.04) and carotid augmentation index (β = 0.31, p = 0.04) (model R 2 = 0.26) as significant determinants of sinotubular junction z score. Conclusions: The aorta stiffens in patients with repaired ToF, which may contribute to progressive dilatation of the aortic root in the long term.
Persistent Identifierhttp://hdl.handle.net/10722/45216
ISSN
2015 Impact Factor: 5.693
2015 SCImago Journal Rankings: 2.647
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorOu, Xen_HK
dc.contributor.authorWong, SJen_HK
dc.date.accessioned2007-10-30T06:20:06Z-
dc.date.available2007-10-30T06:20:06Z-
dc.date.issued2006en_HK
dc.identifier.citationHeart, 2006, v. 92 n. 12, p. 1827-1830en_HK
dc.identifier.issn1355-6037en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45216-
dc.description.abstractObjectives: To test the hypotheses that (1) the central conduit arteries stiffen preferentially over the peripheral conduit arteries in patients with repaired tetralogy of Fallot (ToF); and (2) central arterial stiffening is related to aortic root dilatation. Design and patients: Heart-femoral pulse wave velocity (PWV), femoral-ankle PWV, carotid augmentation index and body surface area-adjusted aortic sinotubular dimension were determined in 31 children after ToF repair and compared with those in 31 age-matched controls after left-to-right shunt repair. In addition, the PWVs and augmentation index were related to the sinotubular junction dimension. Settings: Tertiary paediatric cardiac centre. Results: Compared with controls, patients had significantly greater heart-femoral PWV (mean 666 (SD 151) v 587 (81) cm/s, p = 0.021) and carotid augmentation index (-14.1 (17.0)% v -25.2 (14.6)%, p = 0.016), whereas the right (888 (202) v 845 (207) cm/s, p = 0.42) and left (918 (227) v 851 (215) cm/s, p = 0.25) femoral-ankle PWVs were similar between the two groups. The sinotubular junction z score of patients was significantly greater than that of controls (4.7 (1.5) v 1.1 (1.4), p < 0.001). Univariate analysis showed that the sinotubular junction z score correlated positively with heart-femoral PWV (r = 0.43, p = 0.001) and carotid augmentation index (r = 0.46, p = 0.001). Multiple linear regression similarly identified heart-femoral PWV (β = 0.30, p = 0.04) and carotid augmentation index (β = 0.31, p = 0.04) (model R 2 = 0.26) as significant determinants of sinotubular junction z score. Conclusions: The aorta stiffens in patients with repaired ToF, which may contribute to progressive dilatation of the aortic root in the long term.en_HK
dc.format.extent163242 bytes-
dc.format.extent2258 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_HK
dc.relation.ispartofHearten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsHeart. Copyright © B M J Publishing Group.en_HK
dc.subject.meshAortic Diseases - physiopathologyen_HK
dc.subject.meshTetralogy of Fallot - physiopathology - surgeryen_HK
dc.subject.meshBlood Flow Velocity - physiologyen_HK
dc.subject.meshDilatation, Pathologic - physiopathologyen_HK
dc.subject.meshVascular Resistance - physiologyen_HK
dc.titleCentral and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: Implications or aortic root dilatationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6037&volume=92&issue=12&spage=1827&epage=1830&date=2006&atitle=Central+and+peripheral+arterial+stiffness+in+patients+after+surgical+repair+of+tetralogy+of+Fallot:+implications+for+aortic+root+dilatationen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/hrt.2006.091199en_HK
dc.identifier.pmid16775086-
dc.identifier.pmcidPMC1861289-
dc.identifier.scopuseid_2-s2.0-33845226445en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845226445&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1827en_HK
dc.identifier.epage1830en_HK
dc.identifier.isiWOS:000242048200023-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridOu, X=15122840200en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK

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