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Article: Left ventricular function in beta thalassaemia major

TitleLeft ventricular function in beta thalassaemia major
Authors
Issue Date1989
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives of Disease in Childhood, 1989, v. 64 n. 7, p. 1046-1051 How to Cite?
AbstractThe left ventricular dimension and posterior wall dynamics were studied by computer assisted analysis of M mode echocardiography in 25 normal children (group 1) and 32 transfusion dependent children with beta thalassaemia major who had no evidence of heart failure (group 2). Twenty seven of those in group 2 remained well but five died of cardiac decompensation within 12 months. Compared with group 1, the left ventricular fractional shortening and ejection fraction were normal in those in group 2 who survived but diminished in those who died. Evaluation of left ventricular dimension and posterior wall dynamics during systole (peak shortening rate, peak velocity of circumferential fibre shortening, and peak posterior wall thickening rate) showed similar findings in that only the group who died had abnormal values. The left ventricular dimension and posterior wall diastolic dynamics (peak relaxation rate, normalised peak relaxation, peak wall thinning, and normalised peak wall thinning rate), however, showed progressively slower rates in all the children in group 2. The findings suggest that left ventricular diastolic dysfunction occurs early in myocardial impairment in patients with beta thalassaemia major. When there are abnormalities in both diastole and systole, the myocardial impairment is advanced and the prognosis is poor.
Persistent Identifierhttp://hdl.handle.net/10722/45213
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.118
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, KCen_HK
dc.contributor.authorLi, AMen_HK
dc.contributor.authorHui, PWen_HK
dc.contributor.authorYeung, CYen_HK
dc.date.accessioned2007-10-30T06:20:02Z-
dc.date.available2007-10-30T06:20:02Z-
dc.date.issued1989en_HK
dc.identifier.citationArchives of Disease in Childhood, 1989, v. 64 n. 7, p. 1046-1051en_HK
dc.identifier.issn0003-9888en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45213-
dc.description.abstractThe left ventricular dimension and posterior wall dynamics were studied by computer assisted analysis of M mode echocardiography in 25 normal children (group 1) and 32 transfusion dependent children with beta thalassaemia major who had no evidence of heart failure (group 2). Twenty seven of those in group 2 remained well but five died of cardiac decompensation within 12 months. Compared with group 1, the left ventricular fractional shortening and ejection fraction were normal in those in group 2 who survived but diminished in those who died. Evaluation of left ventricular dimension and posterior wall dynamics during systole (peak shortening rate, peak velocity of circumferential fibre shortening, and peak posterior wall thickening rate) showed similar findings in that only the group who died had abnormal values. The left ventricular dimension and posterior wall diastolic dynamics (peak relaxation rate, normalised peak relaxation, peak wall thinning, and normalised peak wall thinning rate), however, showed progressively slower rates in all the children in group 2. The findings suggest that left ventricular diastolic dysfunction occurs early in myocardial impairment in patients with beta thalassaemia major. When there are abnormalities in both diastole and systole, the myocardial impairment is advanced and the prognosis is poor.en_HK
dc.format.extent812362 bytes-
dc.format.extent3430 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsArchives of Disease in Childhood. Copyright © B M J Publishing Group.en_HK
dc.subject.meshEchocardiography-methodsen_HK
dc.subject.meshHeart-Ventricles-physiopathologyen_HK
dc.subject.meshThalassemia-physiopathologyen_HK
dc.titleLeft ventricular function in beta thalassaemia majoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9888&volume=64&issue=7&spage=1046&epage=1051&date=1989&atitle=Left+ventricular+function+in+beta+thalassaemia+majoren_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid2629627-
dc.identifier.pmcidPMC1792686-
dc.identifier.scopuseid_2-s2.0-0024352407-
dc.identifier.isiWOS:A1989AG36800014-

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