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Article: Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease

TitleRelationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease
Authors
Issue Date2007
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives Of Disease In Childhood, 2007, v. 92 n. 1, p. 43-47 How to Cite?
AbstractBackground: Evidence of premature atherosclerosis and systemic arterial stiffening in patients after Kawasaki disease is accumulating. Aim: To test the hypothesis that carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis, is associated with systemic arterial stiffness in children after Kawasaki disease. Methods: A cohort of 72 patients was studied, comprising 26 patients with Kawasaki disease and coronary aneurysms (group I), 24 patients with Kawasaki disease and normal coronary arteries (group II) and 22 healthy age-matched children (group III). The carotid IMT, carotid artery stiffness index, brachioradial pulse wave velocity (PWV), fasting total cholesterol, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were determined and compared among the three groups. Results: The carotid IMT was related to indices of arterial stiffness, and significant determinants of carotid IMT were identified by multivariate analysis. The mean (standard deviation (SD)) carotid IMT of both group I (0.41 (0.04) mm) and group II (0.39 (0.04) mm) was significantly greater than that of group III (0.36 (0.04) mm; p<0.001 and p = 0.008, respectively). For the entire cohort, carotid IMT correlated positively with LDL cholesterol (r = 0.31, p = 0.009), carotid artery stiffness index (r = 0.40, p = 0.001) and brachioradial PWV (r = 0.28, p = 0.016), but not with age, body mass index, systemic blood pressure, and HDL and total cholesterol. Multiple linear regression analysis identified carotid artery stiffness index (β = 0.25, p = 0.028) and subject grouping (β = -0.39, p = 0.001; model R2 = 0.29) as significant correlates of carotid IMT. Conclusion: The increased carotid IMT in children after Kawasaki disease is associated with systemic arterial stiffening.
Persistent Identifierhttp://hdl.handle.net/10722/45208
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.118
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorWong, SJen_HK
dc.contributor.authorHo, MHKen_HK
dc.date.accessioned2007-10-30T06:19:54Z-
dc.date.available2007-10-30T06:19:54Z-
dc.date.issued2007en_HK
dc.identifier.citationArchives Of Disease In Childhood, 2007, v. 92 n. 1, p. 43-47en_HK
dc.identifier.issn0003-9888en_HK
dc.identifier.urihttp://hdl.handle.net/10722/45208-
dc.description.abstractBackground: Evidence of premature atherosclerosis and systemic arterial stiffening in patients after Kawasaki disease is accumulating. Aim: To test the hypothesis that carotid intima-media thickness (IMT), a surrogate marker of atherosclerosis, is associated with systemic arterial stiffness in children after Kawasaki disease. Methods: A cohort of 72 patients was studied, comprising 26 patients with Kawasaki disease and coronary aneurysms (group I), 24 patients with Kawasaki disease and normal coronary arteries (group II) and 22 healthy age-matched children (group III). The carotid IMT, carotid artery stiffness index, brachioradial pulse wave velocity (PWV), fasting total cholesterol, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were determined and compared among the three groups. Results: The carotid IMT was related to indices of arterial stiffness, and significant determinants of carotid IMT were identified by multivariate analysis. The mean (standard deviation (SD)) carotid IMT of both group I (0.41 (0.04) mm) and group II (0.39 (0.04) mm) was significantly greater than that of group III (0.36 (0.04) mm; p<0.001 and p = 0.008, respectively). For the entire cohort, carotid IMT correlated positively with LDL cholesterol (r = 0.31, p = 0.009), carotid artery stiffness index (r = 0.40, p = 0.001) and brachioradial PWV (r = 0.28, p = 0.016), but not with age, body mass index, systemic blood pressure, and HDL and total cholesterol. Multiple linear regression analysis identified carotid artery stiffness index (β = 0.25, p = 0.028) and subject grouping (β = -0.39, p = 0.001; model R2 = 0.29) as significant correlates of carotid IMT. Conclusion: The increased carotid IMT in children after Kawasaki disease is associated with systemic arterial stiffening.en_HK
dc.format.extent198960 bytes-
dc.format.extent2258 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_HK
dc.relation.ispartofArchives of Disease in Childhooden_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsArchives of Disease in Childhood. Copyright © B M J Publishing Group.en_HK
dc.subject.meshCarotid-Artery,-Common-physiopathologyen_HK
dc.subject.meshMucocutaneous-Lymph-Node-Syndrome-physiopathologyen_HK
dc.subject.meshVascular-Resistance-physiologyen_HK
dc.titleRelationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9888&volume=92&issue=1&spage=43&epage=47&date=2007&atitle=Relationship+between+carotid+intima-media+thickness+and+arterial+stiffness+in+children+after+Kawasaki+diseaseen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/adc.2006.096628en_HK
dc.identifier.pmid16820386-
dc.identifier.pmcidPMC2083125-
dc.identifier.scopuseid_2-s2.0-33846378168en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33846378168&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue1en_HK
dc.identifier.spage43en_HK
dc.identifier.epage47en_HK
dc.identifier.isiWOS:000243005200015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridWong, SJ=25924109100en_HK
dc.identifier.scopusauthoridHo, MHK=8925896400en_HK

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