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Article: Temporal lobe and hypothalamic-pituitary dysfunctions after radiotherapy for nasopharyngeal carcinoma: A distinct clinical syndrome

TitleTemporal lobe and hypothalamic-pituitary dysfunctions after radiotherapy for nasopharyngeal carcinoma: A distinct clinical syndrome
Authors
Issue Date1988
PublisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/
Citation
Journal Of Neurology Neurosurgery And Psychiatry, 1988, v. 51 n. 10, p. 1302-1307 How to Cite?
AbstractEleven patients with combined neurological and endocrine complications after external radiotherapy for nasopharyngeal carcinoma are described. Neurologically, memory disturbance, complex partial seizures and hypodense areas in one or both temporal lobes on CT were typical features. Endocrinologically, hypopituitarism was the prominent manifestation. This constellation of clinical features in a patient with previous radiotherapy to the nasopharynx characterises radiation injury to the inferomedial aspects of the temporal lobes and the hypothalamic-pituitary axis. While the parenchymal brain lesions may mimic metastases or glioma on CT, the associated endocrine disturbance would betray the correct diagnosis. The importance of recognising the hypopituitarism which may be clinically asymptomatic and which is amenable to therapy is emphasised, as is the need for a proper fractionation of the radiation dose to minimise the incidence of these disabling complications.
Persistent Identifierhttp://hdl.handle.net/10722/44990
ISSN
2015 Impact Factor: 6.431
2015 SCImago Journal Rankings: 2.913
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWoo, Een_HK
dc.contributor.authorLam, Ken_HK
dc.contributor.authorYu Ma, YJen_HK
dc.contributor.authorWang, Cen_HK
dc.contributor.authorYeung, RTTen_HK
dc.date.accessioned2007-10-30T06:15:07Z-
dc.date.available2007-10-30T06:15:07Z-
dc.date.issued1988en_HK
dc.identifier.citationJournal Of Neurology Neurosurgery And Psychiatry, 1988, v. 51 n. 10, p. 1302-1307en_HK
dc.identifier.issn0022-3050en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44990-
dc.description.abstractEleven patients with combined neurological and endocrine complications after external radiotherapy for nasopharyngeal carcinoma are described. Neurologically, memory disturbance, complex partial seizures and hypodense areas in one or both temporal lobes on CT were typical features. Endocrinologically, hypopituitarism was the prominent manifestation. This constellation of clinical features in a patient with previous radiotherapy to the nasopharynx characterises radiation injury to the inferomedial aspects of the temporal lobes and the hypothalamic-pituitary axis. While the parenchymal brain lesions may mimic metastases or glioma on CT, the associated endocrine disturbance would betray the correct diagnosis. The importance of recognising the hypopituitarism which may be clinically asymptomatic and which is amenable to therapy is emphasised, as is the need for a proper fractionation of the radiation dose to minimise the incidence of these disabling complications.en_HK
dc.format.extent1606167 bytes-
dc.format.extent3424 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/en_HK
dc.relation.ispartofJournal of Neurology Neurosurgery and Psychiatryen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Neurology, Neurosurgery and Psychiatry. Copyright © B M J Publishing Group.en_HK
dc.subject.meshHypothalamo-Hypophyseal-System-radiation-effectsen_HK
dc.subject.meshNasopharyngeal-Neoplasms-radiotherapyen_HK
dc.subject.meshRadiation-Injuries-etiologyen_HK
dc.subject.meshTemporal-Lobe-radiation-effectsen_HK
dc.titleTemporal lobe and hypothalamic-pituitary dysfunctions after radiotherapy for nasopharyngeal carcinoma: A distinct clinical syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3050&volume=51&issue=10&spage=1302&epage=1307&date=1988&atitle=Temporal+lobe+and+hypothalamic-pituitary+dysfunctions+after+radiotherapy+for+nasopharyngeal+carcinoma:+a+distinct+clinical+syndromeen_HK
dc.identifier.emailLam, K:ksllam@hku.hken_HK
dc.identifier.authorityLam, K=rp00343en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid3225587-
dc.identifier.pmcidPMC1032919-
dc.identifier.scopuseid_2-s2.0-0023748342en_HK
dc.identifier.volume51en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1302en_HK
dc.identifier.epage1307en_HK
dc.identifier.isiWOS:A1988Q462100009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWoo, E=7103371219en_HK
dc.identifier.scopusauthoridLam, K=8082870600en_HK
dc.identifier.scopusauthoridYu Ma, YJ=6504762340en_HK
dc.identifier.scopusauthoridWang, C=7501631357en_HK
dc.identifier.scopusauthoridYeung, RTT=7102833337en_HK

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