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Article: N-hexane neuropathy in offset printers

TitleN-hexane neuropathy in offset printers
Authors
Issue Date1993
PublisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/
Citation
Journal Of Neurology Neurosurgery And Psychiatry, 1993, v. 56 n. 5, p. 538-542 How to Cite?
AbstractIn an offset printing factory with 56 workers, 20 (36%) developed symptomatic peripheral neuropathy due to exposure to n-hexane. Another 26 workers (46%) were found to have subclinical neuropathy. The initial change in the nerve conduction study was reduced amplitude of the sensory action potentials, followed by reduced amplitude of the motor action potentials, reduction in motor conduction velocities and increase in distal latencies. These changes indicate primary axonal degeneration with secondary demyelination. Sural nerve biopsy in a severe case showed giant axonal swellings due to accumulation of 10nm neurofilaments, myelin sheath attentuation and widening of nodal gaps. The development of neuropathy bore no direct relationship to the duration of exposure, hence factors such as individual susceptibility may be important. Optic neuropathy and CNS involvement were uncommon and autonomic neuropathy was not encountered.
Persistent Identifierhttp://hdl.handle.net/10722/44976
ISSN
2015 Impact Factor: 6.431
2015 SCImago Journal Rankings: 2.913
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChang, CMen_HK
dc.contributor.authorYu, CWen_HK
dc.contributor.authorFong, KYen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorTsin, TWen_HK
dc.contributor.authorYu, YLen_HK
dc.contributor.authorCheung, TFen_HK
dc.contributor.authorChan, SYen_HK
dc.date.accessioned2007-10-30T06:14:49Z-
dc.date.available2007-10-30T06:14:49Z-
dc.date.issued1993en_HK
dc.identifier.citationJournal Of Neurology Neurosurgery And Psychiatry, 1993, v. 56 n. 5, p. 538-542en_HK
dc.identifier.issn0022-3050en_HK
dc.identifier.urihttp://hdl.handle.net/10722/44976-
dc.description.abstractIn an offset printing factory with 56 workers, 20 (36%) developed symptomatic peripheral neuropathy due to exposure to n-hexane. Another 26 workers (46%) were found to have subclinical neuropathy. The initial change in the nerve conduction study was reduced amplitude of the sensory action potentials, followed by reduced amplitude of the motor action potentials, reduction in motor conduction velocities and increase in distal latencies. These changes indicate primary axonal degeneration with secondary demyelination. Sural nerve biopsy in a severe case showed giant axonal swellings due to accumulation of 10nm neurofilaments, myelin sheath attentuation and widening of nodal gaps. The development of neuropathy bore no direct relationship to the duration of exposure, hence factors such as individual susceptibility may be important. Optic neuropathy and CNS involvement were uncommon and autonomic neuropathy was not encountered.en_HK
dc.format.extent1676248 bytes-
dc.format.extent3424 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.jnnp.com/en_HK
dc.relation.ispartofJournal of Neurology Neurosurgery and Psychiatryen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Neurology, Neurosurgery and Psychiatry. Copyright © B M J Publishing Group.en_HK
dc.subject.meshDemyelinating-Diseases-chemically-induceden_HK
dc.subject.meshHexanes-toxicityen_HK
dc.subject.meshNerve-Degeneration-drug-effectsen_HK
dc.subject.meshPrinting-en_HK
dc.titleN-hexane neuropathy in offset printersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3050&volume=56&issue=5&spage=538&epage=542&date=1993&atitle=N-hexane+neuropathy+in+offset+printersen_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.emailCheung, TF:rtcheung@hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityCheung, TF=rp00434en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8505647en_HK
dc.identifier.pmcidPMC1015015-
dc.identifier.scopuseid_2-s2.0-0027276980en_HK
dc.identifier.volume56en_HK
dc.identifier.issue5en_HK
dc.identifier.spage538en_HK
dc.identifier.epage542en_HK
dc.identifier.isiWOS:A1993LD45300020-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChang, CM=7407031960en_HK
dc.identifier.scopusauthoridYu, CW=37065619700en_HK
dc.identifier.scopusauthoridFong, KY=8913866800en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridTsin, TW=6507786398en_HK
dc.identifier.scopusauthoridYu, YL=8094845300en_HK
dc.identifier.scopusauthoridCheung, TF=7202397498en_HK
dc.identifier.scopusauthoridChan, SY=7404255960en_HK

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