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Article: Mixed low grade and high grade endometrial stromal sarcoma of uterus: Differences on immunohistochemistry and chromosome in situ hybridisation

TitleMixed low grade and high grade endometrial stromal sarcoma of uterus: Differences on immunohistochemistry and chromosome in situ hybridisation
Authors
KeywordsDedifferentiation
Endometrial stromal sarcoma
Issue Date1996
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1996, v. 49 n. 7, p. 604-607 How to Cite?
AbstractA case of a 64 year old woman with a tumour of the uterus is reported. The patient presented with postmenopausal bleeding and subsequently underwent total hysterectomy and bilateral salpingooophorectomy. Sections of the tumour showed a low grade endometrial stromal sarcoma coexisting with areas consistent with high grade sarcoma. The sarcoma cells, in both the low and high grade areas, were positive for vimentin and negative for desmin and cytokeratin on immunohistochemistry. While the sarcoma cells in the low grade region showed immunoreactivity for oestrogen and progestogen receptors, those in the high grade region did not. Using chromosome in situ hybridisation, the low grade portion of the sarcoma was diploid for chromosomes X, 11, 12, and 17, whereas the more anaplastic areas were aneuploid for these chromosomes. This case may represent an example of high grade endometrial stromal sarcoma arising by dedifferentiation from a low grade stromal sarcoma. Adequate sampling is important in identifying such anaplastic changes as the origin of the tumour will affect patient management.
Persistent Identifierhttp://hdl.handle.net/10722/43602
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorNg, WFen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorKhoo, USen_HK
dc.date.accessioned2007-03-23T04:50:06Z-
dc.date.available2007-03-23T04:50:06Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1996, v. 49 n. 7, p. 604-607en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43602-
dc.description.abstractA case of a 64 year old woman with a tumour of the uterus is reported. The patient presented with postmenopausal bleeding and subsequently underwent total hysterectomy and bilateral salpingooophorectomy. Sections of the tumour showed a low grade endometrial stromal sarcoma coexisting with areas consistent with high grade sarcoma. The sarcoma cells, in both the low and high grade areas, were positive for vimentin and negative for desmin and cytokeratin on immunohistochemistry. While the sarcoma cells in the low grade region showed immunoreactivity for oestrogen and progestogen receptors, those in the high grade region did not. Using chromosome in situ hybridisation, the low grade portion of the sarcoma was diploid for chromosomes X, 11, 12, and 17, whereas the more anaplastic areas were aneuploid for these chromosomes. This case may represent an example of high grade endometrial stromal sarcoma arising by dedifferentiation from a low grade stromal sarcoma. Adequate sampling is important in identifying such anaplastic changes as the origin of the tumour will affect patient management.en_HK
dc.format.extent1402418 bytes-
dc.format.extent25600 bytes-
dc.format.extent3013 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectDedifferentiationen_HK
dc.subjectEndometrial stromal sarcomaen_HK
dc.subject.meshChromosome aberrationsen_HK
dc.subject.meshEndometrial neoplasms - genetics - pathologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn situ hybridizationen_HK
dc.subject.meshSarcoma, endometrial stromal - genetics - pathologyen_HK
dc.titleMixed low grade and high grade endometrial stromal sarcoma of uterus: Differences on immunohistochemistry and chromosome in situ hybridisationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=49&issue=7&spage=604&epage=607&date=1996&atitle=Mixed+low+grade+and+high+grade+endometrial+stromal+sarcoma+of+uterus:+differences+on+immunohistochemistry+and+chromosome+in+situ+hybridisationen_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US: uskhoo@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8813967-
dc.identifier.pmcidPMC500583-
dc.identifier.scopuseid_2-s2.0-0030015754en_HK
dc.identifier.hkuros26156-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030015754&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue7en_HK
dc.identifier.spage604en_HK
dc.identifier.epage607en_HK
dc.identifier.isiWOS:A1996UX09300021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridNg, WF=25940213100en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK

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