File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Use of flow cytometry in the analysis of stage III squamous cell carcinoma of the oesophagus and its association with MIB-1

TitleUse of flow cytometry in the analysis of stage III squamous cell carcinoma of the oesophagus and its association with MIB-1
Authors
KeywordsFlow cytometry
MIB-1 labelling index
Prognosis
Squamous cell carcinoma of the oesophagus
Issue Date1996
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1996, v. 49 n. 12, p. 975-978 How to Cite?
AbstractAims - To examine the prognostic and pathobiological importance of DNA content in oesophageal squamous cell carcinomas in Hong Kong Chinese subjects; to evaluate its association with the immunohistochemical proliferative marker MIB-1. Methods - Paraffin wax embedded tumour tissue and adjacent normal tissue (control tissue) samples from 45 resected stage III oesophageal squamous cell carcinomas were studied using flow cytometric analysis. The DNA content and the clinicopathological data of these patients were analysed together with the MIB-1 labelling index. Results - DNA aneuploidy was present in 14 (31%) of the 45 cases. However, the DNA content did not correlate significantly with the age, sex, or survival of the patients, nor the length, location, differentiation and MIB-1 labelling index of the oesophageal carcinomas. The synthetic (S) phase fraction of diploid tumours bore no relation to the patients' survival or MIB-1 score. Conclusions - Flow cytometry was not as useful as the MIB-1 labelling index in predicting the biological characteristics of the tumours and the prognosis of patients with oesophageal squamous cell carcinomas. This study does not support the routine use of DNA flow cytometric analysis in oesophageal cancers.
Persistent Identifierhttp://hdl.handle.net/10722/43601
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorCheung, LKNen_HK
dc.contributor.authorLuk, TFen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2007-03-23T04:50:05Z-
dc.date.available2007-03-23T04:50:05Z-
dc.date.issued1996en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1996, v. 49 n. 12, p. 975-978en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43601-
dc.description.abstractAims - To examine the prognostic and pathobiological importance of DNA content in oesophageal squamous cell carcinomas in Hong Kong Chinese subjects; to evaluate its association with the immunohistochemical proliferative marker MIB-1. Methods - Paraffin wax embedded tumour tissue and adjacent normal tissue (control tissue) samples from 45 resected stage III oesophageal squamous cell carcinomas were studied using flow cytometric analysis. The DNA content and the clinicopathological data of these patients were analysed together with the MIB-1 labelling index. Results - DNA aneuploidy was present in 14 (31%) of the 45 cases. However, the DNA content did not correlate significantly with the age, sex, or survival of the patients, nor the length, location, differentiation and MIB-1 labelling index of the oesophageal carcinomas. The synthetic (S) phase fraction of diploid tumours bore no relation to the patients' survival or MIB-1 score. Conclusions - Flow cytometry was not as useful as the MIB-1 labelling index in predicting the biological characteristics of the tumours and the prognosis of patients with oesophageal squamous cell carcinomas. This study does not support the routine use of DNA flow cytometric analysis in oesophageal cancers.en_HK
dc.format.extent762717 bytes-
dc.format.extent27648 bytes-
dc.format.extent454989 bytes-
dc.format.extent326 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/octet-stream-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subjectFlow cytometryen_HK
dc.subjectMIB-1 labelling indexen_HK
dc.subjectPrognosisen_HK
dc.subjectSquamous cell carcinoma of the oesophagusen_HK
dc.subject.meshAntibodies, monoclonal - diagnostic useen_HK
dc.subject.meshCarcinoma, squamous cell - genetics - pathologyen_HK
dc.subject.meshEsophageal neoplasms - genetics - pathologyen_HK
dc.subject.meshMitotic indexen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.titleUse of flow cytometry in the analysis of stage III squamous cell carcinoma of the oesophagus and its association with MIB-1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=49&issue=12&spage=975&epage=978&date=1996&atitle=Use+of+flow+cytometry+in+the+analysis+of+stage+III+squamous+cell+carcinoma+of+the+oesophagus+and+its+association+with+MIB-1en_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid9038733-
dc.identifier.pmcidPMC499644-
dc.identifier.scopuseid_2-s2.0-0030427069en_HK
dc.identifier.hkuros26128-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030427069&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue12en_HK
dc.identifier.spage975en_HK
dc.identifier.epage978en_HK
dc.identifier.isiWOS:A1996WA28300007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridMa, L=7403574642en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridCheung, LKN=36555284200en_HK
dc.identifier.scopusauthoridLuk, TF=7003539054en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats