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Article: BRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs

TitleBRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organs
Authors
Issue Date2005
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2005, v. 58 n. 6, p. 640-644 How to Cite?
AbstractBackground: Malignant melanoma arising from different body compartments may be associated with differing aetiological factors and clinical behaviour, and may manifest diverse molecular genetic profiles. Although many studies have focused on cutaneous melanoma, little is known of mucosal and other types of melanoma. In particular, malignant melanoma of soft parts is different from other melanomas in many respects, yet manifests a common melanocytic differentiation. Mutation of BRAF is now known to be common in cutaneous melanomas, and raises possible new therapeutic options of anti-RAF treatment for these patients. Few data are available for non-cutaneous melanomas. Aims: To study the incidence of BRAF and NRAS mutations in melanomas arising in diverse internal organs. Methods: Fifty one melanomas from various internal organs were investigated for BRAF and NRAS mutation by direct DNA sequencing. Results: BRAF and NRAS mutations were found in two and five mucosal melanomas arising from the aerodigestive and female genital tracts (n = 36). Their occurrence is mutually exclusive, giving a combined mutation incidence rate of 19.4% in mucosal melanomas. Both BRAF and NRAS mutations were absent in malignant melanoma of soft parts (n = 7). BRAF mutation was also absent in uveal melanoma (n = 6), but was seen in two of five cutaneous melanomas. The incidence of BRAF or combined BRAF/NRAS mutations in all non-cutaneous groups was significantly lower than published rates for cutaneous melanomas. Conclusion: Each melanoma subtype may have a unique oncogenetic pathway of tumour development, and only a small fraction of non-cutaneous melanomas may benefit from anti-RAF treatment.
Persistent Identifierhttp://hdl.handle.net/10722/43595
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, CWen_HK
dc.contributor.authorFan, YSen_HK
dc.contributor.authorChan, TLen_HK
dc.contributor.authorChan, ASWen_HK
dc.contributor.authorHo, LCen_HK
dc.contributor.authorMa, TKFen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.date.accessioned2007-03-23T04:49:55Z-
dc.date.available2007-03-23T04:49:55Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Clinical Pathology, 2005, v. 58 n. 6, p. 640-644en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43595-
dc.description.abstractBackground: Malignant melanoma arising from different body compartments may be associated with differing aetiological factors and clinical behaviour, and may manifest diverse molecular genetic profiles. Although many studies have focused on cutaneous melanoma, little is known of mucosal and other types of melanoma. In particular, malignant melanoma of soft parts is different from other melanomas in many respects, yet manifests a common melanocytic differentiation. Mutation of BRAF is now known to be common in cutaneous melanomas, and raises possible new therapeutic options of anti-RAF treatment for these patients. Few data are available for non-cutaneous melanomas. Aims: To study the incidence of BRAF and NRAS mutations in melanomas arising in diverse internal organs. Methods: Fifty one melanomas from various internal organs were investigated for BRAF and NRAS mutation by direct DNA sequencing. Results: BRAF and NRAS mutations were found in two and five mucosal melanomas arising from the aerodigestive and female genital tracts (n = 36). Their occurrence is mutually exclusive, giving a combined mutation incidence rate of 19.4% in mucosal melanomas. Both BRAF and NRAS mutations were absent in malignant melanoma of soft parts (n = 7). BRAF mutation was also absent in uveal melanoma (n = 6), but was seen in two of five cutaneous melanomas. The incidence of BRAF or combined BRAF/NRAS mutations in all non-cutaneous groups was significantly lower than published rates for cutaneous melanomas. Conclusion: Each melanoma subtype may have a unique oncogenetic pathway of tumour development, and only a small fraction of non-cutaneous melanomas may benefit from anti-RAF treatment.en_HK
dc.format.extent131228 bytes-
dc.format.extent25088 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshGenes, ras - geneticsen_HK
dc.subject.meshMelanoma - geneticsen_HK
dc.subject.meshNeoplasm proteins - geneticsen_HK
dc.subject.meshMutationen_HK
dc.subject.meshProto-oncogene proteins b-raf - geneticsen_HK
dc.titleBRAF and NRAS mutations are uncommon in melanomas arising in diverse internal organsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=58&issue=6&spage=640&epage=644&date=2005&atitle=BRAF+and+NRAS+mutations+are+uncommon+in+melanomas+arising+in+diverse+internal+organsen_HK
dc.identifier.emailChan, TL:tlchan@hku.hken_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.authorityChan, TL=rp00418en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/jcp.2004.022509en_HK
dc.identifier.pmid15917418-
dc.identifier.pmcidPMC1770697-
dc.identifier.scopuseid_2-s2.0-20444457621en_HK
dc.identifier.hkuros108128-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444457621&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume58en_HK
dc.identifier.issue6en_HK
dc.identifier.spage640en_HK
dc.identifier.epage644en_HK
dc.identifier.isiWOS:000229353300017-
dc.publisher.placeUnited Kingdomen_HK

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