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Article: Assessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen

TitleAssessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigen
Authors
Issue Date1994
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1994, v. 47 n. 7, p. 601-604 How to Cite?
AbstractAims - To assess the role of Ki67 immunoreactivity in predicting the clinical progress of hydatidiform mole. Methods - Tissue from 87 hydatidiform moles, 11 normal first trimester placentas, 11 normal term placentas and 17 spontaneous abortions were examined for expression of Ki67 antigen, using the monoclonal antibody MIB1. Results - Ki67 immunoreactivity was significantly higher in the tissue from normal first trimester placentas than in that from normal term placentas and spontaneous abortions. Among the 87 patients with hydatidiform moles studied, 20 developed persistent gestational trophoblastic disease and required subsequent treatment. There was no statistically significant difference in the Ki67 index between the 20 patients who developed persistent disease and those who did not. Conclusion-Hydatidiform moles which give rise to persistent trophoblastic disease do not have a higher proliferative rate than those which do not. The Ki67 index is not useful for predicting the prognosis of molar pregnancies.
Persistent Identifierhttp://hdl.handle.net/10722/43591
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorCollins, RJen_HK
dc.contributor.authorWong, YLen_HK
dc.date.accessioned2007-03-23T04:49:47Z-
dc.date.available2007-03-23T04:49:47Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1994, v. 47 n. 7, p. 601-604en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43591-
dc.description.abstractAims - To assess the role of Ki67 immunoreactivity in predicting the clinical progress of hydatidiform mole. Methods - Tissue from 87 hydatidiform moles, 11 normal first trimester placentas, 11 normal term placentas and 17 spontaneous abortions were examined for expression of Ki67 antigen, using the monoclonal antibody MIB1. Results - Ki67 immunoreactivity was significantly higher in the tissue from normal first trimester placentas than in that from normal term placentas and spontaneous abortions. Among the 87 patients with hydatidiform moles studied, 20 developed persistent gestational trophoblastic disease and required subsequent treatment. There was no statistically significant difference in the Ki67 index between the 20 patients who developed persistent disease and those who did not. Conclusion-Hydatidiform moles which give rise to persistent trophoblastic disease do not have a higher proliferative rate than those which do not. The Ki67 index is not useful for predicting the prognosis of molar pregnancies.en_HK
dc.format.extent1534883 bytes-
dc.format.extent3013 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.subject.meshHydatidiform mole - immunology - pathologyen_HK
dc.subject.meshAbortion, spontaneousen_HK
dc.subject.meshPlacenta - immunology - pathologyen_HK
dc.subject.meshKi-67 antigenen_HK
dc.subject.meshNeoplasm proteins - analysis - immunologyen_HK
dc.titleAssessment of cell proliferation in hydatidiform mole using monoclonal antibody MIB1 to Ki-67 antigenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=47&issue=7&spage=601&epage=604&date=1994&atitle=Assessment+of+cell+proliferation+in+hydatidiform+mole+using+monoclonal+antibody+MIB1+to+Ki-67+antigenen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailCollins, RJ:rcollins@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCollins, RJ=rp00251en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8089214-
dc.identifier.pmcidPMC502073-
dc.identifier.scopuseid_2-s2.0-0028609787en_HK
dc.identifier.hkuros5114-
dc.identifier.volume47en_HK
dc.identifier.issue7en_HK
dc.identifier.spage601en_HK
dc.identifier.epage604en_HK
dc.identifier.isiWOS:A1994NW73700007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridCollins, RJ=7403350455en_HK
dc.identifier.scopusauthoridWong, YL=7403041884en_HK

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