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Article: The clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas

TitleThe clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomas
Authors
Keywordsp53
Paraganglioma
Phaeochromocytoma
Issue Date2001
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2001, v. 54 n. 6, p. 443-448 How to Cite?
AbstractAims - Phaeochromocytomas and paragangliomas are uncommon. The aims of this study were to analyse the characteristics and the possible roles of p53, Rb, and mdm2 alterations in these tumours. Methods - The clinicopathological features of 65 patients (31 men, 34 women) with phaeochromocytomas or paragangliomas were analysed. The tumours were studied for the expression of p53, Rb, and mdm2 by immunohistochemical methods. Results - Thirty nine of the patients had phaeochromocytomas and 26 had paragangliomas. Bilateral tumours were noted in eight of the patients and malignant tumours were seen in 13. Paragangliomas were often small, non-functional, and presented incidentally, whereas phaeochromocytomas were usually large, functional, and symptomatic, p53 overexpression, loss of Rb expression, and mdm2 overexpression were seen in four, 43, and 37 of the patients, respectively. Three of the four patients with p53 overexpression had bilateral tumours. Loss of Rb expression was often found in phaeochromocytomas, whereas mdm2 overexpression was more frequently seen in paragangliomas. The 10 year survival rate of patients with malignant tumours was 45%. Two patients died of tumour metastases more than 10 years after resection of the primary tumours. Conclusions - Phaeochromocytomas and paragangliomas had distinctive clinical features and genetic alterations. The prognosis of patients with these tumours was related to the malignant potential, p53 overexpression, more common in bilateral phaeochromocytomas and paragangliomas, could be a marker for this tumour subgroup.
Persistent Identifierhttp://hdl.handle.net/10722/43514
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLo, CYen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorLuk, JMen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2007-03-23T04:47:40Z-
dc.date.available2007-03-23T04:47:40Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Clinical Pathology, 2001, v. 54 n. 6, p. 443-448en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43514-
dc.description.abstractAims - Phaeochromocytomas and paragangliomas are uncommon. The aims of this study were to analyse the characteristics and the possible roles of p53, Rb, and mdm2 alterations in these tumours. Methods - The clinicopathological features of 65 patients (31 men, 34 women) with phaeochromocytomas or paragangliomas were analysed. The tumours were studied for the expression of p53, Rb, and mdm2 by immunohistochemical methods. Results - Thirty nine of the patients had phaeochromocytomas and 26 had paragangliomas. Bilateral tumours were noted in eight of the patients and malignant tumours were seen in 13. Paragangliomas were often small, non-functional, and presented incidentally, whereas phaeochromocytomas were usually large, functional, and symptomatic, p53 overexpression, loss of Rb expression, and mdm2 overexpression were seen in four, 43, and 37 of the patients, respectively. Three of the four patients with p53 overexpression had bilateral tumours. Loss of Rb expression was often found in phaeochromocytomas, whereas mdm2 overexpression was more frequently seen in paragangliomas. The 10 year survival rate of patients with malignant tumours was 45%. Two patients died of tumour metastases more than 10 years after resection of the primary tumours. Conclusions - Phaeochromocytomas and paragangliomas had distinctive clinical features and genetic alterations. The prognosis of patients with these tumours was related to the malignant potential, p53 overexpression, more common in bilateral phaeochromocytomas and paragangliomas, could be a marker for this tumour subgroup.en_HK
dc.format.extent208026 bytes-
dc.format.extent26112 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectp53en_HK
dc.subjectParagangliomaen_HK
dc.subjectPhaeochromocytomaen_HK
dc.subject.meshNeoplasm proteins - metabolismen_HK
dc.subject.meshNuclear proteinsen_HK
dc.subject.meshParaganglioma - metabolism - pathologyen_HK
dc.subject.meshPheochromocytoma - metabolism - pathologyen_HK
dc.subject.meshTumor markers, biological - metabolismen_HK
dc.titleThe clinicopathological features and importance of p53, Rb, and mdm2 expression in phaeochromocytomas and paragangliomasen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=54&issue=6&spage=443&epage=448&date=2001&atitle=The+clinicopathological+features+and+importance+of+p53,+Rb,+and+mdm2+expression+in+phaeochromocytomas+and+paragangliomasen_HK
dc.identifier.emailLuk, JM: jmluk@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityLuk, JM=rp00349en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/jcp.54.6.443en_HK
dc.identifier.pmid11376017-
dc.identifier.pmcidPMC1731450-
dc.identifier.scopuseid_2-s2.0-0034983617en_HK
dc.identifier.hkuros85703-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034983617&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue6en_HK
dc.identifier.spage443en_HK
dc.identifier.epage448en_HK
dc.identifier.isiWOS:000169191500005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLo, CY=16417392800en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridLuk, JM=7006777791en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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