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Article: Ventriculo-vascular interactions in patients with β thalassaemia major

TitleVentriculo-vascular interactions in patients with β thalassaemia major
Authors
Issue Date2005
PublisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2005, v. 91 n. 6, p. 769-773 How to Cite?
AbstractObjectives: To determine potential interactions between the heart and arterial system in patients with β thalassaemia major. Design and patients: Vascular compliance, systemic vascular resistance, and left ventricular (LV) contractility was determined in 34 asymptomatic thalassaemia patients at 2-4 hours after blood transfusion and also in 34 age and sex matched controls using a non-invasive device. The results were compared between groups and inter-relationships between LV contractility and indices of vascular load were explored. Setting: Tertiary paediatric cardiac centre. Results: When compared with controls, patients had greater systemic vascular resistance (1633 (259) v 1377 (276) dynes/s/cm5, p < 0.001) and effective arterial elastance (Ea (1.86 (0.25) v 1.65 (0.29) mm Hg/ml, p = 0.001), an index of combined pulsatile and static vascular load. On the other hand, their systolic blood pressure (104 (9) v 112 (13) mm Hg, p = 0.006), pulse pressure (45 (9) v 57 (10) mm Hg, p < 0.001), adjusted systemic vascular compliance (1.21 (0.09) v 1.37 (0.14), p < 0.001), adjusted brachial artery distensibility (21 (0.29) v 7.95 (0.29)%/mm Hg, p < 0.001) and LV+dP/dt (1059 (183) v 1239 (237) mm Hg/s, p = 0.001) were significantly lower. Significant determinants of LV contractility, as reflected by LV+dP/dt, were age (standardised β = -0.24, p = 0.003), body mass index (standardised β = -0.34, p = 0.004), systolic blood pressure (standardised β = 0.90, p < 0.001), and effective Ea(standardised β = -0.50, p < 0.001) (model R2 = 0.69). No significant correlation existed between serum ferritin concentration and any of the cardiac or vascular indices. Conclusion: An unfavourable ventriculo-vascular interaction, as characterised by impaired cardiac contractility and increased static and pulsatile vascular load, occurs in patients with β thalassaemia major.
Persistent Identifierhttp://hdl.handle.net/10722/43150
ISSN
2015 Impact Factor: 5.693
2015 SCImago Journal Rankings: 2.647
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChan, GCFen_HK
dc.date.accessioned2007-03-23T04:40:02Z-
dc.date.available2007-03-23T04:40:02Z-
dc.date.issued2005en_HK
dc.identifier.citationHeart, 2005, v. 91 n. 6, p. 769-773en_HK
dc.identifier.issn1355-6037en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43150-
dc.description.abstractObjectives: To determine potential interactions between the heart and arterial system in patients with β thalassaemia major. Design and patients: Vascular compliance, systemic vascular resistance, and left ventricular (LV) contractility was determined in 34 asymptomatic thalassaemia patients at 2-4 hours after blood transfusion and also in 34 age and sex matched controls using a non-invasive device. The results were compared between groups and inter-relationships between LV contractility and indices of vascular load were explored. Setting: Tertiary paediatric cardiac centre. Results: When compared with controls, patients had greater systemic vascular resistance (1633 (259) v 1377 (276) dynes/s/cm5, p < 0.001) and effective arterial elastance (Ea (1.86 (0.25) v 1.65 (0.29) mm Hg/ml, p = 0.001), an index of combined pulsatile and static vascular load. On the other hand, their systolic blood pressure (104 (9) v 112 (13) mm Hg, p = 0.006), pulse pressure (45 (9) v 57 (10) mm Hg, p < 0.001), adjusted systemic vascular compliance (1.21 (0.09) v 1.37 (0.14), p < 0.001), adjusted brachial artery distensibility (21 (0.29) v 7.95 (0.29)%/mm Hg, p < 0.001) and LV+dP/dt (1059 (183) v 1239 (237) mm Hg/s, p = 0.001) were significantly lower. Significant determinants of LV contractility, as reflected by LV+dP/dt, were age (standardised β = -0.24, p = 0.003), body mass index (standardised β = -0.34, p = 0.004), systolic blood pressure (standardised β = 0.90, p < 0.001), and effective Ea(standardised β = -0.50, p < 0.001) (model R2 = 0.69). No significant correlation existed between serum ferritin concentration and any of the cardiac or vascular indices. Conclusion: An unfavourable ventriculo-vascular interaction, as characterised by impaired cardiac contractility and increased static and pulsatile vascular load, occurs in patients with β thalassaemia major.en_HK
dc.format.extent155824 bytes-
dc.format.extent25600 bytes-
dc.format.extent2190 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_HK
dc.relation.ispartofHearten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsHeart. Copyright © B M J Publishing Group.en_HK
dc.subject.meshArteries - physiopathologyen_HK
dc.subject.meshBlood pressure - physiologyen_HK
dc.subject.meshBeta-thalassemia - complications - physiopathologyen_HK
dc.subject.meshVentricular dysfunction, left - complications - physiopathologyen_HK
dc.subject.meshVascular resistance - physiologyen_HK
dc.titleVentriculo-vascular interactions in patients with β thalassaemia majoren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6037&volume=91&issue=6&spage=769&epage=773&date=2005&atitle=Ventriculo-vascular+interactions+in+patients+with+ß+thalassaemia+majoren_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/hrt.2003.032110en_HK
dc.identifier.pmid15894772-
dc.identifier.pmcidPMC1768942-
dc.identifier.scopuseid_2-s2.0-20044365674en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20044365674&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue6en_HK
dc.identifier.spage769en_HK
dc.identifier.epage773en_HK
dc.identifier.isiWOS:000229125700015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK

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