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Article: Arterial distensibility in children and teenagers: Normal evolution and the effect of childhood vasculitis

TitleArterial distensibility in children and teenagers: Normal evolution and the effect of childhood vasculitis
Authors
Issue Date2002
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives Of Disease In Childhood, 2002, v. 87 n. 4, p. 348-351 How to Cite?
AbstractBackground: Polyarteritis nodosa is a necrotising vasculitis of the medium sized and small muscular arteries. The inflammatory and subsequent reparative processes may alter the arterial mechanical properties. The effect of vasculitic damage on arterial distensibility has never been explored however. Aim: To determine the normal values and the effect of childhood vasculitis on arterial distensibility in children and teenagers. Methods: Distensibility of the brachioradial arterial segment was studied using pulse wave velocity (PWV ∝1/√distensibility), in 13 children with polyarteritis nodosa at a median age of 11.8 (range 4.9-16) years. As a control group, 155 healthy schoolchildren (6-18 years, 81 boys) were studied. PWV was assessed using a photoplethysmographic technique; blood pressure was measured by an automatic sphygmomanometer (Dinamap). Data from patients were expressed as z scores adjusted for age and compared to a population mean of 0 by a single sample t test. Determinants of PWV in normal children were assessed by univariate and multivariate linear regression analyses. Results: Age, height, weight, and systolic blood pressure correlated individually with the brachioradial PWV. Multivariate analysis identified age as the only independent determinant. Ten of the patients were in clinical remission, while three had evidence of disease activity at the time of study. The PWV in the patient group as a whole was significantly greater than those in healthy children (mean z score +0.99). Raised C reactive protein concentration (>2 mg/dl) in the three patients with active disease was associated with a higher PWV when compared to those in remission (z score +2.78 v +0.45). The diastolic blood pressure of the patients was higher than those of the controls (z score + 1.04) while the systolic pressure was similar (z score -0.36). Conclusions: PWV in the brachioradial arterial segment increases gradually during childhood independent of body weight, height, mass, and blood pressure. Increased PWV, and hence decreased distensibility, in this peripheral arterial segment occurs in polyarteritis nodosa and is amplified during acute inflammatory exacerbation.
Persistent Identifierhttp://hdl.handle.net/10722/43145
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.118
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorBrogan, PAen_HK
dc.contributor.authorPilla, CBen_HK
dc.contributor.authorDillon, MJen_HK
dc.contributor.authorRedington, ANen_HK
dc.date.accessioned2007-03-23T04:39:56Z-
dc.date.available2007-03-23T04:39:56Z-
dc.date.issued2002en_HK
dc.identifier.citationArchives Of Disease In Childhood, 2002, v. 87 n. 4, p. 348-351en_HK
dc.identifier.issn0003-9888en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43145-
dc.description.abstractBackground: Polyarteritis nodosa is a necrotising vasculitis of the medium sized and small muscular arteries. The inflammatory and subsequent reparative processes may alter the arterial mechanical properties. The effect of vasculitic damage on arterial distensibility has never been explored however. Aim: To determine the normal values and the effect of childhood vasculitis on arterial distensibility in children and teenagers. Methods: Distensibility of the brachioradial arterial segment was studied using pulse wave velocity (PWV ∝1/√distensibility), in 13 children with polyarteritis nodosa at a median age of 11.8 (range 4.9-16) years. As a control group, 155 healthy schoolchildren (6-18 years, 81 boys) were studied. PWV was assessed using a photoplethysmographic technique; blood pressure was measured by an automatic sphygmomanometer (Dinamap). Data from patients were expressed as z scores adjusted for age and compared to a population mean of 0 by a single sample t test. Determinants of PWV in normal children were assessed by univariate and multivariate linear regression analyses. Results: Age, height, weight, and systolic blood pressure correlated individually with the brachioradial PWV. Multivariate analysis identified age as the only independent determinant. Ten of the patients were in clinical remission, while three had evidence of disease activity at the time of study. The PWV in the patient group as a whole was significantly greater than those in healthy children (mean z score +0.99). Raised C reactive protein concentration (>2 mg/dl) in the three patients with active disease was associated with a higher PWV when compared to those in remission (z score +2.78 v +0.45). The diastolic blood pressure of the patients was higher than those of the controls (z score + 1.04) while the systolic pressure was similar (z score -0.36). Conclusions: PWV in the brachioradial arterial segment increases gradually during childhood independent of body weight, height, mass, and blood pressure. Increased PWV, and hence decreased distensibility, in this peripheral arterial segment occurs in polyarteritis nodosa and is amplified during acute inflammatory exacerbation.en_HK
dc.format.extent213122 bytes-
dc.format.extent25600 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_HK
dc.relation.ispartofArchives of Disease in Childhooden_HK
dc.rightsArchives of Disease in Childhood. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshArteries - physiologyen_HK
dc.subject.meshPhysiopathologyen_HK
dc.subject.meshBlood flow velocityen_HK
dc.subject.meshChild, preschoolen_HK
dc.subject.meshPhotoplethysmographyen_HK
dc.titleArterial distensibility in children and teenagers: Normal evolution and the effect of childhood vasculitisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9888&volume=87&issue=4&spage=348&epage=351&date=2002&atitle=Arterial+distensibility+in+children+and+teenagers:+normal+evolution+and+the+effect+of+childhood+vasculitisen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/adc.87.4.348en_HK
dc.identifier.pmid12244018-
dc.identifier.pmcidPMC1763025-
dc.identifier.scopuseid_2-s2.0-0036789009en_HK
dc.identifier.hkuros74822-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036789009&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume87en_HK
dc.identifier.issue4en_HK
dc.identifier.spage348en_HK
dc.identifier.epage351en_HK
dc.identifier.isiWOS:000178321000029-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridBrogan, PA=7004602186en_HK
dc.identifier.scopusauthoridPilla, CB=6602493640en_HK
dc.identifier.scopusauthoridDillon, MJ=26033402300en_HK
dc.identifier.scopusauthoridRedington, AN=7102622991en_HK

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