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Article: Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation

TitleAberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation
Authors
Issue Date2004
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2004, v. 57 n. 8, p. 861-866 How to Cite?
AbstractAims: To determine gastric expression of trefoil family factor 2 (TFF2) and MUC6 in Helicobacter pylori positive and negative subjects, and its association with antralisation at the gastric incisura. Methods: Gastric biopsies from the antrum, incisura, and body of 76 dyspeptic patients without ulcers were used for the determination of H pylori infection, histological changes, and epithelial TFF2 and MUC6 expression. Results: In the foveola, the rates of TFF2 and MUC6 immunostaining were greater in H pylori infected (n = 27) than in uninfected patients (n = 49) at the antrum (59.3% v 4.1% for TFF2 and 63.0% v 4.1% for MUC6; both p < 0.001) and incisura (44.4% v 2.0% for TFF2 and 48.1% v 0% for MUC6; both p < 0.001). In the deeper glands, the rates were also greater in H pylori infected than in uninfected patients at the incisura (85.2% v 22.4% for both TFF2 and MUC6; p < 0.001). Antral-type mucosa was present at the incisura in 28 of the 76 patients. TFF2 and MUC6 expression in the foveola and deeper glands was significantly associated with antral-type mucosa, independent of H pylori status. Conclusions: Helicobacter pylori infection increases the expression of TFF2 and MUC6 in the gastric epithelium. Aberrant TFF2 and MUC6 expression is associated with antralisation of gastric incisura.
Persistent Identifierhttp://hdl.handle.net/10722/43110
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorYang, Yen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorElia, Gen_HK
dc.contributor.authorWright, NAen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2007-03-23T04:39:04Z-
dc.date.available2007-03-23T04:39:04Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Clinical Pathology, 2004, v. 57 n. 8, p. 861-866en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43110-
dc.description.abstractAims: To determine gastric expression of trefoil family factor 2 (TFF2) and MUC6 in Helicobacter pylori positive and negative subjects, and its association with antralisation at the gastric incisura. Methods: Gastric biopsies from the antrum, incisura, and body of 76 dyspeptic patients without ulcers were used for the determination of H pylori infection, histological changes, and epithelial TFF2 and MUC6 expression. Results: In the foveola, the rates of TFF2 and MUC6 immunostaining were greater in H pylori infected (n = 27) than in uninfected patients (n = 49) at the antrum (59.3% v 4.1% for TFF2 and 63.0% v 4.1% for MUC6; both p < 0.001) and incisura (44.4% v 2.0% for TFF2 and 48.1% v 0% for MUC6; both p < 0.001). In the deeper glands, the rates were also greater in H pylori infected than in uninfected patients at the incisura (85.2% v 22.4% for both TFF2 and MUC6; p < 0.001). Antral-type mucosa was present at the incisura in 28 of the 76 patients. TFF2 and MUC6 expression in the foveola and deeper glands was significantly associated with antral-type mucosa, independent of H pylori status. Conclusions: Helicobacter pylori infection increases the expression of TFF2 and MUC6 in the gastric epithelium. Aberrant TFF2 and MUC6 expression is associated with antralisation of gastric incisura.en_HK
dc.format.extent356191 bytes-
dc.format.extent25600 bytes-
dc.format.extent270804 bytes-
dc.format.extent4936 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshGastric mucosa - chemistryen_HK
dc.subject.meshGastritis - metabolismen_HK
dc.subject.meshHelicobacter infections - metabolismen_HK
dc.subject.meshHelicobacter pylorien_HK
dc.subject.meshMuscle proteinsen_HK
dc.titleAberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=57&issue=8&spage=861&epage=866&date=2004&atitle=Aberrant+Epithelial+Expression+of+Trefoil+Family+Factor+2+and+Mucin+6+in+Helicobacter+pylori+infected+gastric+antrum,+incisura,+and+body+and+its+association+with+antralisationen_HK
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/jcp.2003.015487en_HK
dc.identifier.pmid15280409-
dc.identifier.pmcidPMC1770377-
dc.identifier.scopuseid_2-s2.0-4043122473en_HK
dc.identifier.hkuros89846-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4043122473&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue8en_HK
dc.identifier.spage861en_HK
dc.identifier.epage866en_HK
dc.identifier.isiWOS:000222930100014-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridYang, Y=8675011000en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridElia, G=7005135642en_HK
dc.identifier.scopusauthoridWright, NA=7201531909en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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