File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prevalence of metronidazole resistant Helicobacter pylori strains among Chinese peptic ulcer disease patients and normal controls in Hong Kong

TitlePrevalence of metronidazole resistant Helicobacter pylori strains among Chinese peptic ulcer disease patients and normal controls in Hong Kong
Authors
KeywordsChinese
Helicobacter pylori
metronidazole susceptibility
Issue Date1996
PublisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 1996, v. 38 n. 5, p. 675-678 How to Cite?
AbstractBackground - A study was conducted to evaluate the prevalence of metronidazole resistant Helicobacter pylori strains among the Chinese in Hong Kong. The efficacy of the triple therapy that contains metronidazole as one of the anti-microbial agents in eradication of the metronidazole susceptible and the metronidazole resistant strains was also assessed. Methods - Culture for H pylori was attempted from antral biopsy specimens of 70 peptic ulcer and 51 control subjects. Successfully cultured H pylori strains were tested for metronidazole susceptibility. Twenty six peptic ulcer disease subjects who had received a course of triple therapy were also reassessed four to six weeks later for successful eradication of H pylori infection. Results and conclusions - H pylori was successfully cultured from antral biopsy specimens in 69 of 80 (86%) of the infected subjects. The overall metronidazole resistance rate was 53 · 5% (37 of 69). There was a significantly higher metronidazole resistance rate among H pylori isolates from the asymptomatic controls (20 of 25) than the peptic ulcer disease subjects (17 of 44) (p=0 · 0007). Twenty three of 32 (73%) women and 14 of 37 (38%) men harboured the metronidazole resistant strains. There was no sex or age difference as far as the prevalence of metronidazole resistant strains were concerned within each study group. Pre-treatment metronidazole susceptible H pylori were significantly more likely to respond to the triple therapy used than those with the metronidazole resistant ones (14 of 15 v five of 10) (p=0 · 021).
Persistent Identifierhttp://hdl.handle.net/10722/43079
ISSN
2015 Impact Factor: 14.921
2015 SCImago Journal Rankings: 6.474
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChing, CKen_HK
dc.contributor.authorLeung, KPen_HK
dc.contributor.authorYung, RWHen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2007-03-23T04:38:23Z-
dc.date.available2007-03-23T04:38:23Z-
dc.date.issued1996en_HK
dc.identifier.citationGut, 1996, v. 38 n. 5, p. 675-678en_HK
dc.identifier.issn0017-5749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/43079-
dc.description.abstractBackground - A study was conducted to evaluate the prevalence of metronidazole resistant Helicobacter pylori strains among the Chinese in Hong Kong. The efficacy of the triple therapy that contains metronidazole as one of the anti-microbial agents in eradication of the metronidazole susceptible and the metronidazole resistant strains was also assessed. Methods - Culture for H pylori was attempted from antral biopsy specimens of 70 peptic ulcer and 51 control subjects. Successfully cultured H pylori strains were tested for metronidazole susceptibility. Twenty six peptic ulcer disease subjects who had received a course of triple therapy were also reassessed four to six weeks later for successful eradication of H pylori infection. Results and conclusions - H pylori was successfully cultured from antral biopsy specimens in 69 of 80 (86%) of the infected subjects. The overall metronidazole resistance rate was 53 · 5% (37 of 69). There was a significantly higher metronidazole resistance rate among H pylori isolates from the asymptomatic controls (20 of 25) than the peptic ulcer disease subjects (17 of 44) (p=0 · 0007). Twenty three of 32 (73%) women and 14 of 37 (38%) men harboured the metronidazole resistant strains. There was no sex or age difference as far as the prevalence of metronidazole resistant strains were concerned within each study group. Pre-treatment metronidazole susceptible H pylori were significantly more likely to respond to the triple therapy used than those with the metronidazole resistant ones (14 of 15 v five of 10) (p=0 · 021).en_HK
dc.format.extent609854 bytes-
dc.format.extent28672 bytes-
dc.format.extent2507 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_HK
dc.relation.ispartofGuten_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsGut. Copyright © B M J Publishing Group.en_HK
dc.subjectChineseen_HK
dc.subjectHelicobacter pylorien_HK
dc.subjectmetronidazole susceptibilityen_HK
dc.subject.meshHelicobacter pylori - drug effects - isolation & purificationen_HK
dc.subject.meshHelicobacter infections - drug therapy - ethnologyen_HK
dc.subject.meshAntitrichomonal agents - therapeutic useen_HK
dc.subject.meshAnti-ulcer agents - therapeutic useen_HK
dc.subject.meshMetronidazole - therapeutic useen_HK
dc.titlePrevalence of metronidazole resistant Helicobacter pylori strains among Chinese peptic ulcer disease patients and normal controls in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-5749&volume=38&issue=5&spage=675&epage=678&date=1996&atitle=Prevalence+of+metronidazole+resistant+Helicobacter+pylori+strains+among+Chinese+peptic+ulcer+disease+patients+and+normal+controls+in+Hong+Kongen_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8707111-
dc.identifier.pmcidPMC1383147-
dc.identifier.scopuseid_2-s2.0-0029938341en_HK
dc.identifier.hkuros13561-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029938341&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue5en_HK
dc.identifier.spage675en_HK
dc.identifier.epage678en_HK
dc.identifier.isiWOS:A1996UM88600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChing, CK=7102130825en_HK
dc.identifier.scopusauthoridLeung, KP=16750844200en_HK
dc.identifier.scopusauthoridYung, RWH=7005594277en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats