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Article: Increased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease
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TitleIncreased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease
 
AuthorsCheung, YF1
Ho, MHK1
Tam, SCF2
Yung, TC1
 
Issue Date2004
 
PublisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
 
CitationHeart, 2004, v. 90 n. 11, p. 1281-1285 [How to Cite?]
DOI: http://dx.doi.org/10.1136/hrt.2003.018507
 
AbstractObjectives: To test the hypothesis that low grade inflammation persists after the acute phase and affects arterial stiffness in children with a history of Kawasaki disease. Design and patients: A cohort of 106 children was studied, which comprised 43 patients with Kawasaki disease with coronary aneurysms (group I), 28 patients with Kawasaki disease with normal coronary arteries (group II), and 35 healthy age matched children (group III). Their systemic blood pressure, fasting cholesterol concentrations, serum high sensitivity C reactive protein (hs-CRP) concentrations, and carotid artery stiffness index were compared. Significant determinants of serum hs-CRP concentration and carotid artery stiffness were identified and the relation between hs-CRP concentration and arterial stiffness was investigated. Setting: Tertiary paediatric cardiac centre. Results: Serum hs-CRP concentration of group I patients (median 0.39 mg/l, interquartile range 0.28-0.65 mg/l) was significantly greater than that of group II (median 0.24 mg/l, interquartile range 0.17-0.29 mg/l, p < 0.001) and of group III patients (median 0.25 mg/l, interquartile range 0.18-0.40 mg/l, p < 0.01). Likewise, carotid artery stiffness index of group I patients (mean (SD) 5.07 (1.11)) was significantly greater than that of group II (4.27 (0.83), p = 0.002), and of group III patients (4.24 (0.86), p = 0.001). For the entire cohort, the carotid artery stiffness index correlated positively with log serum hs-CRP concentration (r = 0.24, p = 0.013). In multiple linear regression analysis, age (standardised β = 0.22, p = 0.02), systolic blood pressure (standardised β = 0.28, p = 0.01), log serum hs-CRP concentration (standardised β = 0.21, p = 0.017), and patient grouping (standardised β = -0.36, p < 0.001) were all independently associated with the carotid artery stiffness index. Conclusions: These findings support the possibility of ongoing low grade inflammation late after the acute phase of Kawasaki disease in patients with coronary aneurysms. Furthermore, this low grade inflammation may have a role in increasing systemic arterial stiffness.
 
ISSN1355-6037
2013 Impact Factor: 6.023
2013 SCImago Journal Rankings: 2.793
 
DOIhttp://dx.doi.org/10.1136/hrt.2003.018507
 
PubMed Central IDPMC1768534
 
ISI Accession Number IDWOS:000224477000011
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, YF
 
dc.contributor.authorHo, MHK
 
dc.contributor.authorTam, SCF
 
dc.contributor.authorYung, TC
 
dc.date.accessioned2007-03-23T04:28:03Z
 
dc.date.available2007-03-23T04:28:03Z
 
dc.date.issued2004
 
dc.description.abstractObjectives: To test the hypothesis that low grade inflammation persists after the acute phase and affects arterial stiffness in children with a history of Kawasaki disease. Design and patients: A cohort of 106 children was studied, which comprised 43 patients with Kawasaki disease with coronary aneurysms (group I), 28 patients with Kawasaki disease with normal coronary arteries (group II), and 35 healthy age matched children (group III). Their systemic blood pressure, fasting cholesterol concentrations, serum high sensitivity C reactive protein (hs-CRP) concentrations, and carotid artery stiffness index were compared. Significant determinants of serum hs-CRP concentration and carotid artery stiffness were identified and the relation between hs-CRP concentration and arterial stiffness was investigated. Setting: Tertiary paediatric cardiac centre. Results: Serum hs-CRP concentration of group I patients (median 0.39 mg/l, interquartile range 0.28-0.65 mg/l) was significantly greater than that of group II (median 0.24 mg/l, interquartile range 0.17-0.29 mg/l, p < 0.001) and of group III patients (median 0.25 mg/l, interquartile range 0.18-0.40 mg/l, p < 0.01). Likewise, carotid artery stiffness index of group I patients (mean (SD) 5.07 (1.11)) was significantly greater than that of group II (4.27 (0.83), p = 0.002), and of group III patients (4.24 (0.86), p = 0.001). For the entire cohort, the carotid artery stiffness index correlated positively with log serum hs-CRP concentration (r = 0.24, p = 0.013). In multiple linear regression analysis, age (standardised β = 0.22, p = 0.02), systolic blood pressure (standardised β = 0.28, p = 0.01), log serum hs-CRP concentration (standardised β = 0.21, p = 0.017), and patient grouping (standardised β = -0.36, p < 0.001) were all independently associated with the carotid artery stiffness index. Conclusions: These findings support the possibility of ongoing low grade inflammation late after the acute phase of Kawasaki disease in patients with coronary aneurysms. Furthermore, this low grade inflammation may have a role in increasing systemic arterial stiffness.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent140444 bytes
 
dc.format.extent25600 bytes
 
dc.format.mimetypeapplication/pdf
 
dc.format.mimetypeapplication/msword
 
dc.identifier.citationHeart, 2004, v. 90 n. 11, p. 1281-1285 [How to Cite?]
DOI: http://dx.doi.org/10.1136/hrt.2003.018507
 
dc.identifier.doihttp://dx.doi.org/10.1136/hrt.2003.018507
 
dc.identifier.epage1285
 
dc.identifier.hkuros96310
 
dc.identifier.isiWOS:000224477000011
 
dc.identifier.issn1355-6037
2013 Impact Factor: 6.023
2013 SCImago Journal Rankings: 2.793
 
dc.identifier.issue11
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1768534
 
dc.identifier.pmid15486121
 
dc.identifier.scopuseid_2-s2.0-7244219897
 
dc.identifier.spage1281
 
dc.identifier.urihttp://hdl.handle.net/10722/42621
 
dc.identifier.volume90
 
dc.languageeng
 
dc.publisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHeart
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHeart. Copyright © B M J Publishing Group.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshC-reactive protein - metabolism
 
dc.subject.meshMucocutaneous lymph node syndrome - blood - physiopathology
 
dc.subject.meshVascular resistance - physiology
 
dc.subject.meshCoronary aneurysm - blood - physiopathology
 
dc.subject.meshCarotid arteries - physiology
 
dc.titleIncreased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong