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Article: Increased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease

TitleIncreased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease
Authors
Issue Date2004
PublisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2004, v. 90 n. 11, p. 1281-1285 How to Cite?
Abstract
Objectives: To test the hypothesis that low grade inflammation persists after the acute phase and affects arterial stiffness in children with a history of Kawasaki disease. Design and patients: A cohort of 106 children was studied, which comprised 43 patients with Kawasaki disease with coronary aneurysms (group I), 28 patients with Kawasaki disease with normal coronary arteries (group II), and 35 healthy age matched children (group III). Their systemic blood pressure, fasting cholesterol concentrations, serum high sensitivity C reactive protein (hs-CRP) concentrations, and carotid artery stiffness index were compared. Significant determinants of serum hs-CRP concentration and carotid artery stiffness were identified and the relation between hs-CRP concentration and arterial stiffness was investigated. Setting: Tertiary paediatric cardiac centre. Results: Serum hs-CRP concentration of group I patients (median 0.39 mg/l, interquartile range 0.28-0.65 mg/l) was significantly greater than that of group II (median 0.24 mg/l, interquartile range 0.17-0.29 mg/l, p < 0.001) and of group III patients (median 0.25 mg/l, interquartile range 0.18-0.40 mg/l, p < 0.01). Likewise, carotid artery stiffness index of group I patients (mean (SD) 5.07 (1.11)) was significantly greater than that of group II (4.27 (0.83), p = 0.002), and of group III patients (4.24 (0.86), p = 0.001). For the entire cohort, the carotid artery stiffness index correlated positively with log serum hs-CRP concentration (r = 0.24, p = 0.013). In multiple linear regression analysis, age (standardised β = 0.22, p = 0.02), systolic blood pressure (standardised β = 0.28, p = 0.01), log serum hs-CRP concentration (standardised β = 0.21, p = 0.017), and patient grouping (standardised β = -0.36, p < 0.001) were all independently associated with the carotid artery stiffness index. Conclusions: These findings support the possibility of ongoing low grade inflammation late after the acute phase of Kawasaki disease in patients with coronary aneurysms. Furthermore, this low grade inflammation may have a role in increasing systemic arterial stiffness.
Persistent Identifierhttp://hdl.handle.net/10722/42621
ISSN
2013 Impact Factor: 6.023
2013 SCImago Journal Rankings: 2.793
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorHo, MHKen_HK
dc.contributor.authorTam, SCFen_HK
dc.contributor.authorYung, TCen_HK
dc.date.accessioned2007-03-23T04:28:03Z-
dc.date.available2007-03-23T04:28:03Z-
dc.date.issued2004en_HK
dc.identifier.citationHeart, 2004, v. 90 n. 11, p. 1281-1285en_HK
dc.identifier.issn1355-6037en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42621-
dc.description.abstractObjectives: To test the hypothesis that low grade inflammation persists after the acute phase and affects arterial stiffness in children with a history of Kawasaki disease. Design and patients: A cohort of 106 children was studied, which comprised 43 patients with Kawasaki disease with coronary aneurysms (group I), 28 patients with Kawasaki disease with normal coronary arteries (group II), and 35 healthy age matched children (group III). Their systemic blood pressure, fasting cholesterol concentrations, serum high sensitivity C reactive protein (hs-CRP) concentrations, and carotid artery stiffness index were compared. Significant determinants of serum hs-CRP concentration and carotid artery stiffness were identified and the relation between hs-CRP concentration and arterial stiffness was investigated. Setting: Tertiary paediatric cardiac centre. Results: Serum hs-CRP concentration of group I patients (median 0.39 mg/l, interquartile range 0.28-0.65 mg/l) was significantly greater than that of group II (median 0.24 mg/l, interquartile range 0.17-0.29 mg/l, p < 0.001) and of group III patients (median 0.25 mg/l, interquartile range 0.18-0.40 mg/l, p < 0.01). Likewise, carotid artery stiffness index of group I patients (mean (SD) 5.07 (1.11)) was significantly greater than that of group II (4.27 (0.83), p = 0.002), and of group III patients (4.24 (0.86), p = 0.001). For the entire cohort, the carotid artery stiffness index correlated positively with log serum hs-CRP concentration (r = 0.24, p = 0.013). In multiple linear regression analysis, age (standardised β = 0.22, p = 0.02), systolic blood pressure (standardised β = 0.28, p = 0.01), log serum hs-CRP concentration (standardised β = 0.21, p = 0.017), and patient grouping (standardised β = -0.36, p < 0.001) were all independently associated with the carotid artery stiffness index. Conclusions: These findings support the possibility of ongoing low grade inflammation late after the acute phase of Kawasaki disease in patients with coronary aneurysms. Furthermore, this low grade inflammation may have a role in increasing systemic arterial stiffness.en_HK
dc.format.extent140444 bytes-
dc.format.extent25600 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_HK
dc.relation.ispartofHearten_HK
dc.rightsHeart. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshC-reactive protein - metabolismen_HK
dc.subject.meshMucocutaneous lymph node syndrome - blood - physiopathologyen_HK
dc.subject.meshVascular resistance - physiologyen_HK
dc.subject.meshCoronary aneurysm - blood - physiopathologyen_HK
dc.subject.meshCarotid arteries - physiologyen_HK
dc.titleIncreased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6037&volume=90&issue=11&spage=1281&epage=1285&date=2004&atitle=Increased+high+sensitivity+C+reactive+protein+concentrations+and+increased+arterial+stiffness+in+children+with+a+history+of+Kawasaki+diseaseen_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/hrt.2003.018507en_HK
dc.identifier.pmid15486121en_HK
dc.identifier.pmcidPMC1768534-
dc.identifier.scopuseid_2-s2.0-7244219897en_HK
dc.identifier.hkuros96310-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7244219897&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume90en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1281en_HK
dc.identifier.epage1285en_HK
dc.identifier.isiWOS:000224477000011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridHo, MHK=8925896400en_HK
dc.identifier.scopusauthoridTam, SCF=7202037323en_HK
dc.identifier.scopusauthoridYung, TC=9132842300en_HK

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