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Article: Relation of arterial stiffness with gestational age and birth weight

TitleRelation of arterial stiffness with gestational age and birth weight
Authors
Issue Date2004
PublisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/
Citation
Archives Of Disease In Childhood, 2004, v. 89 n. 3, p. 217-221 How to Cite?
AbstractBackground: The cardiovascular risk of individuals who are born small as a result of prematurity remains controversial. Given the previous findings of stiffer peripheral conduit arteries in growth restricted donor twins in twin-twin transfusion syndrome regardless of gestational age, we hypothesised that among children born preterm, only those with intrauterine growth retardation are predisposed to an increase in cardiovascular risks. Aim: To compare brachioradial arterial stiffness and systemic blood pressure (BP) among children born preterm and small for gestational age (group 1, n = 15), those born preterm but having birth weight appropriate for gestational age (group 2, n = 36), and those born at term with birth weight appropriate for gestational age (group 3, n = 35). Methods: Systemic BP was measured by an automated device (Dinamap), while stiffness of the brachioradial arterial segment was assessed by measuring pulse wave velocity (PWV). The birth weight was adjusted for gestational age and expressed as a z score for analysis. Results: The 86 children were studied at a mean (SD) age of 8.2 (1.7) years. Subjects from group 1, who were born at 32.3 (2.0) weeks' gestation had a significantly lower z score of birth weight (-2.29 (0.63), p<0.001), compared with those from groups 2 and 3. They had a significantly higher mean blood pressure (p<0.001) and their diastolic blood pressure also tended to be higher (p=0.07). Likewise, their brachioradial PWV, and hence arterial stiffness, was the highest of the three groups (p<0.001). While subjects from group 2 were similarly born preterm, their PWV was not significantly different from that of group 3 subjects (p=1.00) and likewise their z score of birth weight did not differ(-0.01 (0.71) v-0.04 (1.1), p=1.00). Brachioradial PWV correlated significantly with systolic (r=0.31, p=0.004), diastolic (r=0.38, p<0.001), and mean (0.47, p<0.001) BP, and with z score of birth weight (r=-0.43, p<0.001). Multiple linear regression identified mean BP and z score of birth weight as significant determinants of PWV. Conclusion: The findings of the present study support the hypothesis that among children born preterm, only those with intrauterine growth retardation are disadvantaged as a result of increase in systemic arterial stiffness and mean blood pressure.
Persistent Identifierhttp://hdl.handle.net/10722/42429
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.118
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, YFen_HK
dc.contributor.authorWong, KYen_HK
dc.contributor.authorBarbara C Cen_HK
dc.contributor.authorLam, BCCen_HK
dc.contributor.authorTsoi, NSen_HK
dc.date.accessioned2007-01-29T08:49:47Z-
dc.date.available2007-01-29T08:49:47Z-
dc.date.issued2004en_HK
dc.identifier.citationArchives Of Disease In Childhood, 2004, v. 89 n. 3, p. 217-221en_HK
dc.identifier.issn0003-9888en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42429-
dc.description.abstractBackground: The cardiovascular risk of individuals who are born small as a result of prematurity remains controversial. Given the previous findings of stiffer peripheral conduit arteries in growth restricted donor twins in twin-twin transfusion syndrome regardless of gestational age, we hypothesised that among children born preterm, only those with intrauterine growth retardation are predisposed to an increase in cardiovascular risks. Aim: To compare brachioradial arterial stiffness and systemic blood pressure (BP) among children born preterm and small for gestational age (group 1, n = 15), those born preterm but having birth weight appropriate for gestational age (group 2, n = 36), and those born at term with birth weight appropriate for gestational age (group 3, n = 35). Methods: Systemic BP was measured by an automated device (Dinamap), while stiffness of the brachioradial arterial segment was assessed by measuring pulse wave velocity (PWV). The birth weight was adjusted for gestational age and expressed as a z score for analysis. Results: The 86 children were studied at a mean (SD) age of 8.2 (1.7) years. Subjects from group 1, who were born at 32.3 (2.0) weeks' gestation had a significantly lower z score of birth weight (-2.29 (0.63), p<0.001), compared with those from groups 2 and 3. They had a significantly higher mean blood pressure (p<0.001) and their diastolic blood pressure also tended to be higher (p=0.07). Likewise, their brachioradial PWV, and hence arterial stiffness, was the highest of the three groups (p<0.001). While subjects from group 2 were similarly born preterm, their PWV was not significantly different from that of group 3 subjects (p=1.00) and likewise their z score of birth weight did not differ(-0.01 (0.71) v-0.04 (1.1), p=1.00). Brachioradial PWV correlated significantly with systolic (r=0.31, p=0.004), diastolic (r=0.38, p<0.001), and mean (0.47, p<0.001) BP, and with z score of birth weight (r=-0.43, p<0.001). Multiple linear regression identified mean BP and z score of birth weight as significant determinants of PWV. Conclusion: The findings of the present study support the hypothesis that among children born preterm, only those with intrauterine growth retardation are disadvantaged as a result of increase in systemic arterial stiffness and mean blood pressure.en_HK
dc.format.extent239818 bytes-
dc.format.extent25600 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypeapplication/msword-
dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://www.archdischild.com/en_HK
dc.relation.ispartofArchives of Disease in Childhooden_HK
dc.rightsArchives of Disease in Childhood. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshBirth weight - physiologyen_HK
dc.subject.meshBlood flow velocity - physiologyen_HK
dc.subject.meshInfant, premature - physiologyen_HK
dc.subject.meshPulsatile flow - physiologyen_HK
dc.subject.meshVascular resistance - physiologyen_HK
dc.titleRelation of arterial stiffness with gestational age and birth weighten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9888&volume=89&issue=3&spage=217&epage=221&date=2004&atitle=Relation+of+arterial+stiffness+with+gestational+age+and+birth+weighten_HK
dc.identifier.emailCheung, YF:xfcheung@hku.hken_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/adc.2003.025999en_HK
dc.identifier.pmid14977693-
dc.identifier.pmcidPMC1719813-
dc.identifier.scopuseid_2-s2.0-1542374110en_HK
dc.identifier.hkuros85604-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542374110&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue3en_HK
dc.identifier.spage217en_HK
dc.identifier.epage221en_HK
dc.identifier.isiWOS:000189104700009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK
dc.identifier.scopusauthoridWong, KY=7404758500en_HK
dc.identifier.scopusauthoridBarbara C C=35232370900en_HK
dc.identifier.scopusauthoridLam, BCC=8553938300en_HK
dc.identifier.scopusauthoridTsoi, NS=6603693887en_HK

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