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Article: Lymphoepithelial carcinoma of the salivary gland: In situ detection of Epstein-Barr virus
Title | Lymphoepithelial carcinoma of the salivary gland: In situ detection of Epstein-Barr virus |
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Authors | |
Keywords | Epstein-Barr virus Lymphoepithelial carcinoma Salivary gland |
Issue Date | 1995 |
Publisher | B M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/ |
Citation | Journal Of Clinical Pathology, 1995, v. 48 n. 11, p. 1022-1027 How to Cite? |
Abstract | Aim - To examine the role of Epstein-Barr virus (EBV) in lymphoepithelial carcinoma of the salivary gland in Hong Kong Chinese. Methods - Ten cases of lymphoepithelial carcinoma of the salivary gland (eight parotid and two submandibular) were examined. In situ hybridisation was used to localise EBER RNA, immunohistochemical methods to detect expression of latent membrane protein 1 (LMP-1) in EBV positive tumours, and Southern blot analysis to examine the clonality of EBV in the two cases where frozen tissue was available. Results - None of the cases had a history of Sjogren's syndrome or histological evidence of a benign lymphoepithelial lesion. The IgA antibody titre against EBV viral capsid antigen was elevated in four cases. All cases were EBV positive by in situ hybridisation, with a strong uniform positive signal in the epithelial cells, and all cases expressed LMP-1. Southern blot analysis revealed that the clonal episomal form of the virus was present. Two of the three female patients in this series also developed carcinoma of cervix. One of these carcinomas had histological features of a lymphoepithelioma-like carcinoma but was EBV negative. Conclusions - A consistent association between EBV and lymphoepithelial carcinoma of the salivary gland was found. The presence of the virus in a clonal episomal form, and the expression of LMP-1 viral oncoprotein is further evidence of the role of EBV in the oncogenesis of this tumour. |
Persistent Identifier | http://hdl.handle.net/10722/42314 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.934 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Leung, SY | en_HK |
dc.contributor.author | Chung, LP | en_HK |
dc.contributor.author | Yuen, ST | en_HK |
dc.contributor.author | Ho, CM | en_HK |
dc.contributor.author | Wong, MP | en_HK |
dc.contributor.author | Chan, SY | en_HK |
dc.date.accessioned | 2007-01-08T02:34:23Z | - |
dc.date.available | 2007-01-08T02:34:23Z | - |
dc.date.issued | 1995 | en_HK |
dc.identifier.citation | Journal Of Clinical Pathology, 1995, v. 48 n. 11, p. 1022-1027 | en_HK |
dc.identifier.issn | 0021-9746 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/42314 | - |
dc.description.abstract | Aim - To examine the role of Epstein-Barr virus (EBV) in lymphoepithelial carcinoma of the salivary gland in Hong Kong Chinese. Methods - Ten cases of lymphoepithelial carcinoma of the salivary gland (eight parotid and two submandibular) were examined. In situ hybridisation was used to localise EBER RNA, immunohistochemical methods to detect expression of latent membrane protein 1 (LMP-1) in EBV positive tumours, and Southern blot analysis to examine the clonality of EBV in the two cases where frozen tissue was available. Results - None of the cases had a history of Sjogren's syndrome or histological evidence of a benign lymphoepithelial lesion. The IgA antibody titre against EBV viral capsid antigen was elevated in four cases. All cases were EBV positive by in situ hybridisation, with a strong uniform positive signal in the epithelial cells, and all cases expressed LMP-1. Southern blot analysis revealed that the clonal episomal form of the virus was present. Two of the three female patients in this series also developed carcinoma of cervix. One of these carcinomas had histological features of a lymphoepithelioma-like carcinoma but was EBV negative. Conclusions - A consistent association between EBV and lymphoepithelial carcinoma of the salivary gland was found. The presence of the virus in a clonal episomal form, and the expression of LMP-1 viral oncoprotein is further evidence of the role of EBV in the oncogenesis of this tumour. | en_HK |
dc.format.extent | 786431 bytes | - |
dc.format.extent | 225 bytes | - |
dc.format.extent | 225 bytes | - |
dc.format.extent | 225 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | text/plain | - |
dc.language | eng | en_HK |
dc.publisher | B M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/ | en_HK |
dc.relation.ispartof | Journal of Clinical Pathology | en_HK |
dc.rights | Journal of Clinical Pathology. Copyright © B M J Publishing Group. | en_HK |
dc.subject | Epstein-Barr virus | en_HK |
dc.subject | Lymphoepithelial carcinoma | en_HK |
dc.subject | Salivary gland | en_HK |
dc.subject.mesh | Carcinoma, squamous cell - ethnology - pathology - virology | en_HK |
dc.subject.mesh | Herpesviridae infections - complications - pathology | en_HK |
dc.subject.mesh | Herpesvirus 4, human - immunology - isolation & purification | en_HK |
dc.subject.mesh | Immunoenzyme techniques | en_HK |
dc.subject.mesh | In situ hybridization | en_HK |
dc.title | Lymphoepithelial carcinoma of the salivary gland: In situ detection of Epstein-Barr virus | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=48&issue=11&spage=1022&epage=1027&date=1995&atitle=Lymphoepithelial+carcinoma+of+the+salivary+gland:+in+situ+detection+of+Epstein-Barr+virus | en_HK |
dc.identifier.email | Leung, SY: suetyi@hku.hk | en_HK |
dc.identifier.email | Chung, LP: lpchung@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, MP: mwpik@hkucc.hku.hk | en_HK |
dc.identifier.authority | Leung, SY=rp00359 | en_HK |
dc.identifier.authority | Chung, LP=rp00249 | en_HK |
dc.identifier.authority | Wong, MP=rp00348 | en_HK |
dc.description.nature | published_or_final_version | en_HK |
dc.identifier.doi | 10.1136/jcp.48.11.1022 | - |
dc.identifier.pmid | 8543624 | - |
dc.identifier.pmcid | PMC503007 | - |
dc.identifier.scopus | eid_2-s2.0-0028824772 | en_HK |
dc.identifier.hkuros | 9745 | - |
dc.identifier.volume | 48 | en_HK |
dc.identifier.issue | 11 | en_HK |
dc.identifier.spage | 1022 | en_HK |
dc.identifier.epage | 1027 | en_HK |
dc.identifier.isi | WOS:A1995TF18200011 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Leung, SY=7202044886 | en_HK |
dc.identifier.scopusauthorid | Chung, LP=24315879100 | en_HK |
dc.identifier.scopusauthorid | Yuen, ST=7103160927 | en_HK |
dc.identifier.scopusauthorid | Ho, CM=7404652540 | en_HK |
dc.identifier.scopusauthorid | Wong, MP=7403907887 | en_HK |
dc.identifier.scopusauthorid | Chan, SY=7404255845 | en_HK |
dc.identifier.issnl | 0021-9746 | - |