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Article: Lymphoepithelial carcinoma of the salivary gland: In situ detection of Epstein-Barr virus

TitleLymphoepithelial carcinoma of the salivary gland: In situ detection of Epstein-Barr virus
Authors
KeywordsEpstein-Barr virus
Lymphoepithelial carcinoma
Salivary gland
Issue Date1995
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 1995, v. 48 n. 11, p. 1022-1027 How to Cite?
AbstractAim - To examine the role of Epstein-Barr virus (EBV) in lymphoepithelial carcinoma of the salivary gland in Hong Kong Chinese. Methods - Ten cases of lymphoepithelial carcinoma of the salivary gland (eight parotid and two submandibular) were examined. In situ hybridisation was used to localise EBER RNA, immunohistochemical methods to detect expression of latent membrane protein 1 (LMP-1) in EBV positive tumours, and Southern blot analysis to examine the clonality of EBV in the two cases where frozen tissue was available. Results - None of the cases had a history of Sjogren's syndrome or histological evidence of a benign lymphoepithelial lesion. The IgA antibody titre against EBV viral capsid antigen was elevated in four cases. All cases were EBV positive by in situ hybridisation, with a strong uniform positive signal in the epithelial cells, and all cases expressed LMP-1. Southern blot analysis revealed that the clonal episomal form of the virus was present. Two of the three female patients in this series also developed carcinoma of cervix. One of these carcinomas had histological features of a lymphoepithelioma-like carcinoma but was EBV negative. Conclusions - A consistent association between EBV and lymphoepithelial carcinoma of the salivary gland was found. The presence of the virus in a clonal episomal form, and the expression of LMP-1 viral oncoprotein is further evidence of the role of EBV in the oncogenesis of this tumour.
Persistent Identifierhttp://hdl.handle.net/10722/42314
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorHo, CMen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorChan, SYen_HK
dc.date.accessioned2007-01-08T02:34:23Z-
dc.date.available2007-01-08T02:34:23Z-
dc.date.issued1995en_HK
dc.identifier.citationJournal Of Clinical Pathology, 1995, v. 48 n. 11, p. 1022-1027en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42314-
dc.description.abstractAim - To examine the role of Epstein-Barr virus (EBV) in lymphoepithelial carcinoma of the salivary gland in Hong Kong Chinese. Methods - Ten cases of lymphoepithelial carcinoma of the salivary gland (eight parotid and two submandibular) were examined. In situ hybridisation was used to localise EBER RNA, immunohistochemical methods to detect expression of latent membrane protein 1 (LMP-1) in EBV positive tumours, and Southern blot analysis to examine the clonality of EBV in the two cases where frozen tissue was available. Results - None of the cases had a history of Sjogren's syndrome or histological evidence of a benign lymphoepithelial lesion. The IgA antibody titre against EBV viral capsid antigen was elevated in four cases. All cases were EBV positive by in situ hybridisation, with a strong uniform positive signal in the epithelial cells, and all cases expressed LMP-1. Southern blot analysis revealed that the clonal episomal form of the virus was present. Two of the three female patients in this series also developed carcinoma of cervix. One of these carcinomas had histological features of a lymphoepithelioma-like carcinoma but was EBV negative. Conclusions - A consistent association between EBV and lymphoepithelial carcinoma of the salivary gland was found. The presence of the virus in a clonal episomal form, and the expression of LMP-1 viral oncoprotein is further evidence of the role of EBV in the oncogenesis of this tumour.en_HK
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dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
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dc.languageengen_HK
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectEpstein-Barr virusen_HK
dc.subjectLymphoepithelial carcinomaen_HK
dc.subjectSalivary glanden_HK
dc.subject.meshCarcinoma, squamous cell - ethnology - pathology - virologyen_HK
dc.subject.meshHerpesviridae infections - complications - pathologyen_HK
dc.subject.meshHerpesvirus 4, human - immunology - isolation & purificationen_HK
dc.subject.meshImmunoenzyme techniquesen_HK
dc.subject.meshIn situ hybridizationen_HK
dc.titleLymphoepithelial carcinoma of the salivary gland: In situ detection of Epstein-Barr virusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-9746&volume=48&issue=11&spage=1022&epage=1027&date=1995&atitle=Lymphoepithelial+carcinoma+of+the+salivary+gland:+in+situ+detection+of+Epstein-Barr+virusen_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.pmid8543624-
dc.identifier.pmcidPMC503007-
dc.identifier.scopuseid_2-s2.0-0028824772en_HK
dc.identifier.hkuros9745-
dc.identifier.volume48en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1022en_HK
dc.identifier.epage1027en_HK
dc.identifier.isiWOS:A1995TF18200011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridHo, CM=7404652540en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridChan, SY=7404255845en_HK

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