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Article: Assessment of left ventricular function long term after arterial switch operation for transposition of the great arteries by dobutamine stress echocardiography
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TitleAssessment of left ventricular function long term after arterial switch operation for transposition of the great arteries by dobutamine stress echocardiography
 
AuthorsHui, L1
Chau, AKT1
Leung, MP1
Chiu, CS1
Cheung, YF1
 
Issue Date2005
 
PublisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
 
CitationHeart, 2005, v. 91 n. 1, p. 68-72 [How to Cite?]
DOI: http://dx.doi.org/10.1136/hrt.2003.027524
 
AbstractObjectives: To use dobutamine stress echocardiography to determine left ventricular (LV) function and wall motion of children long term after arterial switch operation (ASO) for transposition of the great arteries. Design and patients: 31 patients (24 boys) with ASO performed at a mean (SD) of 15.5 (4.3) days of life were studied at an age of 9.4 (2.0) years. All had normal coronary angiographic findings. LV echocardiographic indexes, including fractional shortening, ejection fraction, rate corrected velocity of circumferential fibre shortening (VCFc), and wall stress, as well as LV wall motion abnormalities were determined at rest and under dobutamine stress. The results were compared with those of 20 healthy age matched control participants. Setting: Tertiary paediatric cardiac centre. Results: Fractional shortening, ejection fraction, and VCFc were significantly lower in patients than in controls at rest (all with p < 0.001). Stress-velocity index detected impaired LV contractility in 19 (61%) patients at rest. An older age at operation (p = 0.01), longer bypass (p = 0.01) and circulatory arrest times (p = 0.045), and an unusual coronary artery pattern (p = 0.059) were associated with impaired resting LV contractility. Dobutamine stress echocardiography unmasked wall motion abnormalities in 23 (74%) patients. Exercise myocardial perfusion scan, performed in 22 patients, showed reversible myocardial perfusion defects in 17. These defects corresponded to segments of hypokinesia as detected by dobutamine stress echocardiography. Conclusion: A significant proportion of children, albeit asymptomatic, had impaired baseline LV contractility and reversible myocardial perfusion defects and mild wall motion abnormalities on stress after ASO.
 
ISSN1355-6037
2013 Impact Factor: 6.023
2013 SCImago Journal Rankings: 2.793
 
DOIhttp://dx.doi.org/10.1136/hrt.2003.027524
 
PubMed Central IDPMC1768615
 
ISI Accession Number IDWOS:000225777100016
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHui, L
 
dc.contributor.authorChau, AKT
 
dc.contributor.authorLeung, MP
 
dc.contributor.authorChiu, CS
 
dc.contributor.authorCheung, YF
 
dc.date.accessioned2007-01-08T02:30:53Z
 
dc.date.available2007-01-08T02:30:53Z
 
dc.date.issued2005
 
dc.description.abstractObjectives: To use dobutamine stress echocardiography to determine left ventricular (LV) function and wall motion of children long term after arterial switch operation (ASO) for transposition of the great arteries. Design and patients: 31 patients (24 boys) with ASO performed at a mean (SD) of 15.5 (4.3) days of life were studied at an age of 9.4 (2.0) years. All had normal coronary angiographic findings. LV echocardiographic indexes, including fractional shortening, ejection fraction, rate corrected velocity of circumferential fibre shortening (VCFc), and wall stress, as well as LV wall motion abnormalities were determined at rest and under dobutamine stress. The results were compared with those of 20 healthy age matched control participants. Setting: Tertiary paediatric cardiac centre. Results: Fractional shortening, ejection fraction, and VCFc were significantly lower in patients than in controls at rest (all with p < 0.001). Stress-velocity index detected impaired LV contractility in 19 (61%) patients at rest. An older age at operation (p = 0.01), longer bypass (p = 0.01) and circulatory arrest times (p = 0.045), and an unusual coronary artery pattern (p = 0.059) were associated with impaired resting LV contractility. Dobutamine stress echocardiography unmasked wall motion abnormalities in 23 (74%) patients. Exercise myocardial perfusion scan, performed in 22 patients, showed reversible myocardial perfusion defects in 17. These defects corresponded to segments of hypokinesia as detected by dobutamine stress echocardiography. Conclusion: A significant proportion of children, albeit asymptomatic, had impaired baseline LV contractility and reversible myocardial perfusion defects and mild wall motion abnormalities on stress after ASO.
 
dc.description.naturepublished_or_final_version
 
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dc.format.extent3357 bytes
 
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dc.format.mimetypeapplication/pdf
 
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dc.identifier.citationHeart, 2005, v. 91 n. 1, p. 68-72 [How to Cite?]
DOI: http://dx.doi.org/10.1136/hrt.2003.027524
 
dc.identifier.doihttp://dx.doi.org/10.1136/hrt.2003.027524
 
dc.identifier.epage72
 
dc.identifier.hkuros96992
 
dc.identifier.isiWOS:000225777100016
 
dc.identifier.issn1355-6037
2013 Impact Factor: 6.023
2013 SCImago Journal Rankings: 2.793
 
dc.identifier.issue1
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1768615
 
dc.identifier.pmid15604338
 
dc.identifier.scopuseid_2-s2.0-10844288905
 
dc.identifier.spage68
 
dc.identifier.urihttp://hdl.handle.net/10722/42171
 
dc.identifier.volume91
 
dc.languageeng
 
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofHeart
 
dc.relation.referencesReferences in Scopus
 
dc.rightsHeart. Copyright © B M J Publishing Group.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAdolescent
 
dc.subject.meshEchocardiography, stress
 
dc.subject.meshHeart septum
 
dc.subject.meshHemodynamic processes
 
dc.subject.meshVentricular dysfunction, left
 
dc.titleAssessment of left ventricular function long term after arterial switch operation for transposition of the great arteries by dobutamine stress echocardiography
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong