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Article: Assessment of left ventricular function long term after arterial switch operation for transposition of the great arteries by dobutamine stress echocardiography

TitleAssessment of left ventricular function long term after arterial switch operation for transposition of the great arteries by dobutamine stress echocardiography
Authors
Issue Date2005
PublisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2005, v. 91 n. 1, p. 68-72 How to Cite?
AbstractObjectives: To use dobutamine stress echocardiography to determine left ventricular (LV) function and wall motion of children long term after arterial switch operation (ASO) for transposition of the great arteries. Design and patients: 31 patients (24 boys) with ASO performed at a mean (SD) of 15.5 (4.3) days of life were studied at an age of 9.4 (2.0) years. All had normal coronary angiographic findings. LV echocardiographic indexes, including fractional shortening, ejection fraction, rate corrected velocity of circumferential fibre shortening (VCFc), and wall stress, as well as LV wall motion abnormalities were determined at rest and under dobutamine stress. The results were compared with those of 20 healthy age matched control participants. Setting: Tertiary paediatric cardiac centre. Results: Fractional shortening, ejection fraction, and VCFc were significantly lower in patients than in controls at rest (all with p < 0.001). Stress-velocity index detected impaired LV contractility in 19 (61%) patients at rest. An older age at operation (p = 0.01), longer bypass (p = 0.01) and circulatory arrest times (p = 0.045), and an unusual coronary artery pattern (p = 0.059) were associated with impaired resting LV contractility. Dobutamine stress echocardiography unmasked wall motion abnormalities in 23 (74%) patients. Exercise myocardial perfusion scan, performed in 22 patients, showed reversible myocardial perfusion defects in 17. These defects corresponded to segments of hypokinesia as detected by dobutamine stress echocardiography. Conclusion: A significant proportion of children, albeit asymptomatic, had impaired baseline LV contractility and reversible myocardial perfusion defects and mild wall motion abnormalities on stress after ASO.
Persistent Identifierhttp://hdl.handle.net/10722/42171
ISSN
2014 Impact Factor: 5.595
2014 SCImago Journal Rankings: 2.710
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, Len_HK
dc.contributor.authorChau, AKTen_HK
dc.contributor.authorLeung, MPen_HK
dc.contributor.authorChiu, CSen_HK
dc.contributor.authorCheung, YFen_HK
dc.date.accessioned2007-01-08T02:30:53Z-
dc.date.available2007-01-08T02:30:53Z-
dc.date.issued2005en_HK
dc.identifier.citationHeart, 2005, v. 91 n. 1, p. 68-72en_HK
dc.identifier.issn1355-6037en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42171-
dc.description.abstractObjectives: To use dobutamine stress echocardiography to determine left ventricular (LV) function and wall motion of children long term after arterial switch operation (ASO) for transposition of the great arteries. Design and patients: 31 patients (24 boys) with ASO performed at a mean (SD) of 15.5 (4.3) days of life were studied at an age of 9.4 (2.0) years. All had normal coronary angiographic findings. LV echocardiographic indexes, including fractional shortening, ejection fraction, rate corrected velocity of circumferential fibre shortening (VCFc), and wall stress, as well as LV wall motion abnormalities were determined at rest and under dobutamine stress. The results were compared with those of 20 healthy age matched control participants. Setting: Tertiary paediatric cardiac centre. Results: Fractional shortening, ejection fraction, and VCFc were significantly lower in patients than in controls at rest (all with p < 0.001). Stress-velocity index detected impaired LV contractility in 19 (61%) patients at rest. An older age at operation (p = 0.01), longer bypass (p = 0.01) and circulatory arrest times (p = 0.045), and an unusual coronary artery pattern (p = 0.059) were associated with impaired resting LV contractility. Dobutamine stress echocardiography unmasked wall motion abnormalities in 23 (74%) patients. Exercise myocardial perfusion scan, performed in 22 patients, showed reversible myocardial perfusion defects in 17. These defects corresponded to segments of hypokinesia as detected by dobutamine stress echocardiography. Conclusion: A significant proportion of children, albeit asymptomatic, had impaired baseline LV contractility and reversible myocardial perfusion defects and mild wall motion abnormalities on stress after ASO.en_HK
dc.format.extent90510 bytes-
dc.format.extent3357 bytes-
dc.format.extent4482 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_HK
dc.relation.ispartofHearten_HK
dc.rightsHeart. Copyright © B M J Publishing Group.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdolescenten_HK
dc.subject.meshEchocardiography, stressen_HK
dc.subject.meshHeart septumen_HK
dc.subject.meshHemodynamic processesen_HK
dc.subject.meshVentricular dysfunction, leften_HK
dc.titleAssessment of left ventricular function long term after arterial switch operation for transposition of the great arteries by dobutamine stress echocardiographyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1355-6037&volume=91&issue=1&spage=68&epage=72&date=2005&atitle=Assessment+of+left+ventricular+function+long+term+after+arterial+switch+operation+for+transposition+of+the+great+arteries+by+dobutamine+stress+echocardiographyen_HK
dc.identifier.emailHui, L: huic@hkucc.hku.hken_HK
dc.identifier.emailCheung, YF: xfcheung@hku.hken_HK
dc.identifier.authorityHui, L=rp01698en_HK
dc.identifier.authorityCheung, YF=rp00382en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1136/hrt.2003.027524en_HK
dc.identifier.pmid15604338en_HK
dc.identifier.pmcidPMC1768615-
dc.identifier.scopuseid_2-s2.0-10844288905en_HK
dc.identifier.hkuros96992-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10844288905&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue1en_HK
dc.identifier.spage68en_HK
dc.identifier.epage72en_HK
dc.identifier.isiWOS:000225777100016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHui, L=12774460100en_HK
dc.identifier.scopusauthoridChau, AKT=35787094400en_HK
dc.identifier.scopusauthoridLeung, MP=7201944800en_HK
dc.identifier.scopusauthoridChiu, CS=8714554800en_HK
dc.identifier.scopusauthoridCheung, YF=7202111067en_HK

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