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Article: Role of hepatitis B virus genotypes in chronic hepatitis B exacerbation

TitleRole of hepatitis B virus genotypes in chronic hepatitis B exacerbation
Authors
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2003, v. 37 n. 4, p. 593-597 How to Cite?
AbstractHepatitis B virus (HBV) genotypes and precore and core promoter mutations were determined in 318 patients with HBV. Patients infected with HBV genotype B had a higher median alanine aminotransferase level and bilirubin level and a lower median albumin level during exacerbations of disease, compared with patients infected with HBV genotype C (all P < .001). By logistic regression analysis, HBV genotype B infection (P = .014) and low albumin levels (P = .006) were independently associated with a higher risk of hepatic decompensation during severe exacerbations of disease. Patients infected with genotype B had a significantly higher mortality due to hepatic decompensation than did patients with genotype C (70% vs. 27.8%; P = .05).
Persistent Identifierhttp://hdl.handle.net/10722/42157
ISSN
2015 Impact Factor: 8.736
2015 SCImago Journal Rankings: 4.742
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorSablon, Een_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorYuan, HJen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2007-01-08T02:30:27Z-
dc.date.available2007-01-08T02:30:27Z-
dc.date.issued2003en_HK
dc.identifier.citationClinical Infectious Diseases, 2003, v. 37 n. 4, p. 593-597en_HK
dc.identifier.issn1058-4838en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42157-
dc.description.abstractHepatitis B virus (HBV) genotypes and precore and core promoter mutations were determined in 318 patients with HBV. Patients infected with HBV genotype B had a higher median alanine aminotransferase level and bilirubin level and a lower median albumin level during exacerbations of disease, compared with patients infected with HBV genotype C (all P < .001). By logistic regression analysis, HBV genotype B infection (P = .014) and low albumin levels (P = .006) were independently associated with a higher risk of hepatic decompensation during severe exacerbations of disease. Patients infected with genotype B had a significantly higher mortality due to hepatic decompensation than did patients with genotype C (70% vs. 27.8%; P = .05).en_HK
dc.format.extent94729 bytes-
dc.format.extent3035 bytes-
dc.format.extent2319 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_HK
dc.relation.ispartofClinical Infectious Diseasesen_HK
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAlanine transaminase - metabolismen_HK
dc.subject.meshHepatitis b virus - classification - geneticsen_HK
dc.subject.meshHepatitis b, chronic - metabolismen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshGenotypeen_HK
dc.titleRole of hepatitis B virus genotypes in chronic hepatitis B exacerbationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=37&issue=4&spage=593&epage=597&date=2003&atitle=Role+of+hepatitis+B+virus+genotypes+in+chronic+hepatitis+B+exacerbationen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, DKH:danywong@hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/376988en_HK
dc.identifier.pmid12905145-
dc.identifier.scopuseid_2-s2.0-0041941607en_HK
dc.identifier.hkuros81370-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041941607&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue4en_HK
dc.identifier.spage593en_HK
dc.identifier.epage597en_HK
dc.identifier.isiWOS:000184618900018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridSablon, E=6603694538en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridYuan, HJ=7402446707en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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