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Article: Relationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus

TitleRelationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus
Authors
Issue Date2002
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2002, v. 186 n. 9, p. 1335-1338 How to Cite?
AbstractChinese patients with chronic hepatitis B virus (332 with and 44 without cirrhosis-related complications) were studied. Fifty percent of patients <30 years old had precore mutations. The prevalence of precore mutations among hepatitis B e antigen (HBeAg)-positive patients, although lower than that among anti-HBe-positive patients (P = .031), was already high (44.2%). Median HBV DNA level in anti-HBe-positive patients was 1.5 × 106-1.55 × 106 copies/mL, irrespective of the presence or absence of precore mutations. There was no difference in the prevalence of precore mutations between patients with and without complications (P, not significant). However the prevalence of core promoter mutations was higher among patients with complications than among those without complications (90.5% vs. 69.3%, respectively; P = .003). In conclusion, precore mutations occurred in a large proportion of Chinese patients with chronic hepatitis B virus before HBeAg seroconversion. The development of complications was not related to precore mutations but was probably due to the persistence of significant viremia after HBeAg seroconversion.
Persistent Identifierhttp://hdl.handle.net/10722/42156
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorSablon, Een_HK
dc.contributor.authorYuan, HJen_HK
dc.contributor.authorHui, CKen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorDoutreloigne, Jen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2007-01-08T02:30:26Z-
dc.date.available2007-01-08T02:30:26Z-
dc.date.issued2002en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2002, v. 186 n. 9, p. 1335-1338en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42156-
dc.description.abstractChinese patients with chronic hepatitis B virus (332 with and 44 without cirrhosis-related complications) were studied. Fifty percent of patients <30 years old had precore mutations. The prevalence of precore mutations among hepatitis B e antigen (HBeAg)-positive patients, although lower than that among anti-HBe-positive patients (P = .031), was already high (44.2%). Median HBV DNA level in anti-HBe-positive patients was 1.5 × 106-1.55 × 106 copies/mL, irrespective of the presence or absence of precore mutations. There was no difference in the prevalence of precore mutations between patients with and without complications (P, not significant). However the prevalence of core promoter mutations was higher among patients with complications than among those without complications (90.5% vs. 69.3%, respectively; P = .003). In conclusion, precore mutations occurred in a large proportion of Chinese patients with chronic hepatitis B virus before HBeAg seroconversion. The development of complications was not related to precore mutations but was probably due to the persistence of significant viremia after HBeAg seroconversion.en_HK
dc.format.extent73749 bytes-
dc.format.extent3035 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshHepatitis b core antigens - geneticsen_HK
dc.subject.meshHepatitis b, chronic - classification - diagnosisen_HK
dc.subject.meshMutationen_HK
dc.subject.meshPromoter regions (genetics)en_HK
dc.subject.meshHepatitis b virus - geneticsen_HK
dc.titleRelationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=186&issue=9&spage=1335&epage=1338&date=2002&atitle=Relationship+between+the+Development+of+Precore+and+Core+Promoter+Mutations+and+Hepatitis+B+e+Antigen+Seroconversion+in+Patients+with+Chronic+Hepatitis+B+Virusen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, DKH:danywong@hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/344327en_HK
dc.identifier.pmid12402204-
dc.identifier.scopuseid_2-s2.0-0036838283en_HK
dc.identifier.hkuros80564-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036838283&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume186en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1335en_HK
dc.identifier.epage1338en_HK
dc.identifier.isiWOS:000178577500017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridSablon, E=6603694538en_HK
dc.identifier.scopusauthoridYuan, HJ=7402446707en_HK
dc.identifier.scopusauthoridHui, CK=7202876933en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridDoutreloigne, J=6603727456en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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