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Article: Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: A comparison with genotype 1

TitleInterferon and ribavirin therapy for chronic hepatitis C virus genotype 6: A comparison with genotype 1
Authors
Issue Date2003
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2003, v. 187 n. 7, p. 1071-1074 How to Cite?
AbstractBecause there is a lack of data on the treatment outcome of patients who carry hepatitis C virus (HCV) genotype 6, we conducted a prospective study, to compare the effect of interferon and ribavirin therapy in HCV genotypes 1 and 6, of patients with seropositive anti-HCV, persistently elevated alanine transaminase levels, and detectable HCV RNA. Patients were treated with subcutaneous recombinant interferon α-2b and ribavirin for 12 months. Of 40 patients, 16 had genotype 6, and 24 had genotype 1. An end-of-treatment response was detected in 12 (75%) patients with genotype 6 and in 10 (41.6%) patients with genotype 1 (P = .05). A sustained virological response (SVR) was present in 10 (62.5%) patients with genotype 6 and in 7 (29.2%) patients with genotype 1 (P = .04). Genotype 6 has a better response than genotype 1 and is associated with a higher SVR.
Persistent Identifierhttp://hdl.handle.net/10722/42154
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, CKen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorSablon, Een_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorWong, BCYen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2007-01-08T02:30:24Z-
dc.date.available2007-01-08T02:30:24Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2003, v. 187 n. 7, p. 1071-1074en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/42154-
dc.description.abstractBecause there is a lack of data on the treatment outcome of patients who carry hepatitis C virus (HCV) genotype 6, we conducted a prospective study, to compare the effect of interferon and ribavirin therapy in HCV genotypes 1 and 6, of patients with seropositive anti-HCV, persistently elevated alanine transaminase levels, and detectable HCV RNA. Patients were treated with subcutaneous recombinant interferon α-2b and ribavirin for 12 months. Of 40 patients, 16 had genotype 6, and 24 had genotype 1. An end-of-treatment response was detected in 12 (75%) patients with genotype 6 and in 10 (41.6%) patients with genotype 1 (P = .05). A sustained virological response (SVR) was present in 10 (62.5%) patients with genotype 6 and in 7 (29.2%) patients with genotype 1 (P = .04). Genotype 6 has a better response than genotype 1 and is associated with a higher SVR.en_HK
dc.format.extent85405 bytes-
dc.format.extent3035 bytes-
dc.format.extent2319 bytes-
dc.format.mimetypeapplication/pdf-
dc.format.mimetypetext/plain-
dc.format.mimetypetext/plain-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org en_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.rightsJournal of Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntiviral agents - therapeutic useen_HK
dc.subject.meshHepacivirus - drug effects - geneticsen_HK
dc.subject.meshHepatitis c, chronic - drug therapy - virologyen_HK
dc.subject.meshInterferon alfa-2b - pharmacology - therapeutic useen_HK
dc.subject.meshRibavirin - pharmacology - therapeutic useen_HK
dc.titleInterferon and ribavirin therapy for chronic hepatitis C virus genotype 6: A comparison with genotype 1en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-1899&volume=187&issue=7&spage=1071&epage=1074&date=2003&atitle=Interferon+and+Ribavirin+Therapy+for+Chronic+Hepatitis+C+Virus+Genotype+6:+A+Comparison+with+Genotype+1en_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1086/368217en_HK
dc.identifier.pmid12660921-
dc.identifier.scopuseid_2-s2.0-0037385492en_HK
dc.identifier.hkuros80554-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037385492&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume187en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1071en_HK
dc.identifier.epage1074en_HK
dc.identifier.isiWOS:000181713000006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHui, CK=7202876933en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridSablon, E=6603694538en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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