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Conference Paper: Siderophore-Antibiotic Conjugation Combating Antimicrobial Resistance
Title | Siderophore-Antibiotic Conjugation Combating Antimicrobial Resistance |
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Authors | |
Issue Date | 2020 |
Citation | The 27th Symposium on Chemistry Postgraduate Research in Hong Kong, Online Meeting, Hong Kong, 17 October 2020 How to Cite? |
Abstract | Pathogenic bacteria scavenge ferric iron from the host for survival and proliferation using small-molecular chelators, siderophores1. Siderophore-antibiotic conjugates, also called sideromycins, which were designed based on a “Trojan Horse” strategy wherein features enabled active uptake to bypass the Gram-negative cell wall, have been expected to be an efficient weapon for multidrug resistant strains caused infections in the clinic2. Herein, the siderophore-antibiotic conjugates were introduced to enhance the antimicrobial activity against Gram-negative bacteria. Through an optimized 11 steps synthesis route based on Miller’s work3, succinylated protected siderophore was synthesized and conjugated with ciprofloxacin (S1-Cip). Furthermore, a symmetric iron chelator conjugated with ciprofloxacin (S2-Cip) was designed and synthesized to investigate the antibacterial activity. |
Description | Organizer: The University of Hong Kong |
Persistent Identifier | http://hdl.handle.net/10722/294212 |
DC Field | Value | Language |
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dc.contributor.author | Wang, C | - |
dc.contributor.author | Zhang, H | - |
dc.contributor.author | Wang, R | - |
dc.contributor.author | Toy, PH | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Sun, H | - |
dc.date.accessioned | 2020-11-23T08:28:01Z | - |
dc.date.available | 2020-11-23T08:28:01Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | The 27th Symposium on Chemistry Postgraduate Research in Hong Kong, Online Meeting, Hong Kong, 17 October 2020 | - |
dc.identifier.uri | http://hdl.handle.net/10722/294212 | - |
dc.description | Organizer: The University of Hong Kong | - |
dc.description.abstract | Pathogenic bacteria scavenge ferric iron from the host for survival and proliferation using small-molecular chelators, siderophores1. Siderophore-antibiotic conjugates, also called sideromycins, which were designed based on a “Trojan Horse” strategy wherein features enabled active uptake to bypass the Gram-negative cell wall, have been expected to be an efficient weapon for multidrug resistant strains caused infections in the clinic2. Herein, the siderophore-antibiotic conjugates were introduced to enhance the antimicrobial activity against Gram-negative bacteria. Through an optimized 11 steps synthesis route based on Miller’s work3, succinylated protected siderophore was synthesized and conjugated with ciprofloxacin (S1-Cip). Furthermore, a symmetric iron chelator conjugated with ciprofloxacin (S2-Cip) was designed and synthesized to investigate the antibacterial activity. | - |
dc.language | eng | - |
dc.relation.ispartof | The 27th Symposium on Chemistry Postgraduate Research in Hong Kong, 2020 | - |
dc.title | Siderophore-Antibiotic Conjugation Combating Antimicrobial Resistance | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Zhang, H: hmzhang8@hku.hk | - |
dc.identifier.email | Wang, R: u3002771@connect.hku.hk | - |
dc.identifier.email | Toy, PH: phtoy@hkucc.hku.hk | - |
dc.identifier.email | Li, H: hylichem@hku.hk | - |
dc.identifier.email | Sun, H: hsun@hku.hk | - |
dc.identifier.authority | Toy, PH=rp00791 | - |
dc.identifier.authority | Sun, H=rp00777 | - |
dc.identifier.hkuros | 319117 | - |