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Article: A prospective pilot study of the effect of acupuncture on insulin sensitivity in women with polycystic ovary syndrome and insulin resistance

TitleA prospective pilot study of the effect of acupuncture on insulin sensitivity in women with polycystic ovary syndrome and insulin resistance
Authors
Keywordsacupuncture
insulin resistance
insulin sensitivity
polycystic ovary syndrome
Issue Date2020
PublisherSAGE Publications. The Journal's web site is located at http://v2.sherpa.ac.uk/id/publisher/65
Citation
Acupuncture in Medicine, 2020, v. 38 n. 5, p. 310-318 How to Cite?
AbstractObjective: To test the hypothesis that acupuncture improves insulin sensitivity in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Design: Prospective pilot study. Setting: Guangzhou, China, 2014–2016. Participants: Eighty women with PCOS aged 18–40 years with body mass index (BMI) above 18.5 kg/m2 and with homeostatic model assessment for insulin resistance (HOMA-IR) index ⩾2.14. Interventions: Subjects received acupuncture with combined manual and low-frequency electrical stimulation of the needles three times per week for 6 months. Primary and secondary outcome measures: The primary outcome was the change in HOMA-IR after 6 months of acupuncture relative to baseline. Secondary outcomes included changes after 6 months of acupuncture and at 3 months of follow-up (both relative to baseline) in oral glucose tolerance test (OGTT) parameters (glucose and insulin levels), anthropometric measurements, and circulating metabolic and endocrine variables. Results: HOMA-IR and fasting plasma glucose and insulin levels were significantly decreased after 6 months of acupuncture, and both HOMA-IR and fasting insulin remained significantly decreased at 3 months of follow-up. In a subgroup analysis of normal-weight and overweight/obese women, HOMA-IR was reduced after 6 months of acupuncture in both subgroups, but there was no significant difference between the two groups. Conclusions: Acupuncture treatment in Chinese women with PCOS and IR was associated with an encouraging improvement in insulin sensitivity. Further randomized controlled studies are required to confirm the efficacy of acupuncture for this indication. © The Author(s) 2020.
Persistent Identifierhttp://hdl.handle.net/10722/290700
ISSN
2019 Impact Factor: 2.129
2015 SCImago Journal Rankings: 0.582

 

DC FieldValueLanguage
dc.contributor.authorLi, J-
dc.contributor.authorWu, W-
dc.contributor.authorStener-Victorin, E-
dc.contributor.authorNg, EHY-
dc.contributor.authorLi, RHW-
dc.contributor.authorLi, M-
dc.contributor.authorLiu, H-
dc.contributor.authorLai, M-
dc.contributor.authorMeng, Y-
dc.contributor.authorZheng, Y-
dc.contributor.authorXia, Y-
dc.contributor.authorMa, H-
dc.date.accessioned2020-11-02T05:45:53Z-
dc.date.available2020-11-02T05:45:53Z-
dc.date.issued2020-
dc.identifier.citationAcupuncture in Medicine, 2020, v. 38 n. 5, p. 310-318-
dc.identifier.issn0964-5284-
dc.identifier.urihttp://hdl.handle.net/10722/290700-
dc.description.abstractObjective: To test the hypothesis that acupuncture improves insulin sensitivity in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Design: Prospective pilot study. Setting: Guangzhou, China, 2014–2016. Participants: Eighty women with PCOS aged 18–40 years with body mass index (BMI) above 18.5 kg/m2 and with homeostatic model assessment for insulin resistance (HOMA-IR) index ⩾2.14. Interventions: Subjects received acupuncture with combined manual and low-frequency electrical stimulation of the needles three times per week for 6 months. Primary and secondary outcome measures: The primary outcome was the change in HOMA-IR after 6 months of acupuncture relative to baseline. Secondary outcomes included changes after 6 months of acupuncture and at 3 months of follow-up (both relative to baseline) in oral glucose tolerance test (OGTT) parameters (glucose and insulin levels), anthropometric measurements, and circulating metabolic and endocrine variables. Results: HOMA-IR and fasting plasma glucose and insulin levels were significantly decreased after 6 months of acupuncture, and both HOMA-IR and fasting insulin remained significantly decreased at 3 months of follow-up. In a subgroup analysis of normal-weight and overweight/obese women, HOMA-IR was reduced after 6 months of acupuncture in both subgroups, but there was no significant difference between the two groups. Conclusions: Acupuncture treatment in Chinese women with PCOS and IR was associated with an encouraging improvement in insulin sensitivity. Further randomized controlled studies are required to confirm the efficacy of acupuncture for this indication. © The Author(s) 2020.-
dc.languageeng-
dc.publisherSAGE Publications. The Journal's web site is located at http://v2.sherpa.ac.uk/id/publisher/65-
dc.relation.ispartofAcupuncture in Medicine-
dc.rightsAcupuncture in Medicine. Copyright © SAGE Publications.-
dc.subjectacupuncture-
dc.subjectinsulin resistance-
dc.subjectinsulin sensitivity-
dc.subjectpolycystic ovary syndrome-
dc.titleA prospective pilot study of the effect of acupuncture on insulin sensitivity in women with polycystic ovary syndrome and insulin resistance-
dc.typeArticle-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.emailLi, RHW: raymondli@hku.hk-
dc.identifier.authorityNg, EHY=rp00426-
dc.identifier.authorityLi, RHW=rp01649-
dc.description.naturepostprint-
dc.identifier.doi10.1177/0964528420902144-
dc.identifier.pmid32249617-
dc.identifier.scopuseid_2-s2.0-85082960560-
dc.identifier.hkuros318093-
dc.identifier.volume38-
dc.identifier.issue5-
dc.identifier.spage310-
dc.identifier.epage318-
dc.publisher.placeUnited Kingdom-

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