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Conference Paper: Microstructural brain changes associated with neurocognitive and functional outcomes of intracranial germ cell tumor (GCT) survivors – a diffusional kurtosis imaging study

TitleMicrostructural brain changes associated with neurocognitive and functional outcomes of intracranial germ cell tumor (GCT) survivors – a diffusional kurtosis imaging study
Authors
Keywordsmagnetic resonance imaging
radiation therapy
neurotoxicity syndromes
diffusion
germ cells
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at https://academic.oup.com/neuro-oncology
Citation
The 19th International Symposium on Pediatric Neuro-Oncology (ISPNO) 2020, Karuizawa, Japan, 13-16 December 2020. In Neuro-Oncology, 2020, v. 22 n. Suppl. 3, p. iii436 How to Cite?
AbstractBACKGROUND: Childhood intracranial germ cell tumour (iGCT) survivors are prone to radiotherapy-related neurotoxicity which can lead to neurocognitive dysfunction. Diffusion kurtosis imaging (DKI) is a MRI technique that quantifies microstructural changes in the grey and white matter of the brain. This study aims to investigate the associations between MR-DKI metrics, the cognitive and functional outcomes of childhood iGCT survivors. METHOD: 20 childhood iGCT survivors who had received cranial radiotherapy were recruited. DKI parameters were determined for iGCT survivors and 18 control subjects. Neurocognitive assessment using the Hong Kong Wechsler Intelligence Scales for Children (HKWISC)/ Wechsler Adult Intelligence Scale – Revised (WAIS-R) and functional assessment using the Lansky/ Karnofsky performance scales were performed for GCT survivors. RESULTS: There were significant negative correlation between the IQ scores and the mean diffusivity (MD) in multiple white matter regions of iGCT survivors including: anterior limb of internal capsule, superior fronto-occipital fasciculus, anterior corona radiata, uncinate fasciculus, cingulum and hippocampus. Mean kurtosis (MK) values of the superior fronto-occipital fasciculus were positively correlated with IQ scores. For grey matter, the MD of the olfactory, insula, caudate, heschl gyrus, parahippocampal gyrus, hippocampus, anterior cingulum, frontal inferior operculum, middle and superior temporal gyrus, middle and superior frontal orbital gyri, cuneus and precentral gyrus were negatively correlated with IQ scores. Most of the microstructural changes with associated functional impairment were white matter regions. CONCLUSION: Our study identified vulnerable brain regions with significant white and grey matter microstructural changes that were associated with impaired cognitive function or deficits in physical functioning.
DescriptionPoster presentation - Section: Neuropsychology/Quality of Life - no. QOL-25
Persistent Identifierhttp://hdl.handle.net/10722/288272
ISSN
2019 Impact Factor: 10.247
2015 SCImago Journal Rankings: 3.196
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorTso, WYW-
dc.contributor.authorHui, ESK-
dc.contributor.authorLee, TMC-
dc.contributor.authorLiu, APY-
dc.contributor.authorIp, P-
dc.contributor.authorCheng, K-
dc.contributor.authorFong, DYT-
dc.contributor.authorChang, DHF-
dc.contributor.authorHo, FKW-
dc.contributor.authorYip, KM-
dc.contributor.authorKu, D-
dc.contributor.authorCheuk, DKL-
dc.contributor.authorLuk, CW-
dc.contributor.authorShing, MMK-
dc.contributor.authorLeung, LK-
dc.contributor.authorKhong, PL-
dc.contributor.authorChan, GCF-
dc.date.accessioned2020-10-05T12:10:26Z-
dc.date.available2020-10-05T12:10:26Z-
dc.date.issued2020-
dc.identifier.citationThe 19th International Symposium on Pediatric Neuro-Oncology (ISPNO) 2020, Karuizawa, Japan, 13-16 December 2020. In Neuro-Oncology, 2020, v. 22 n. Suppl. 3, p. iii436-
dc.identifier.issn1522-8517-
dc.identifier.urihttp://hdl.handle.net/10722/288272-
dc.descriptionPoster presentation - Section: Neuropsychology/Quality of Life - no. QOL-25-
dc.description.abstractBACKGROUND: Childhood intracranial germ cell tumour (iGCT) survivors are prone to radiotherapy-related neurotoxicity which can lead to neurocognitive dysfunction. Diffusion kurtosis imaging (DKI) is a MRI technique that quantifies microstructural changes in the grey and white matter of the brain. This study aims to investigate the associations between MR-DKI metrics, the cognitive and functional outcomes of childhood iGCT survivors. METHOD: 20 childhood iGCT survivors who had received cranial radiotherapy were recruited. DKI parameters were determined for iGCT survivors and 18 control subjects. Neurocognitive assessment using the Hong Kong Wechsler Intelligence Scales for Children (HKWISC)/ Wechsler Adult Intelligence Scale – Revised (WAIS-R) and functional assessment using the Lansky/ Karnofsky performance scales were performed for GCT survivors. RESULTS: There were significant negative correlation between the IQ scores and the mean diffusivity (MD) in multiple white matter regions of iGCT survivors including: anterior limb of internal capsule, superior fronto-occipital fasciculus, anterior corona radiata, uncinate fasciculus, cingulum and hippocampus. Mean kurtosis (MK) values of the superior fronto-occipital fasciculus were positively correlated with IQ scores. For grey matter, the MD of the olfactory, insula, caudate, heschl gyrus, parahippocampal gyrus, hippocampus, anterior cingulum, frontal inferior operculum, middle and superior temporal gyrus, middle and superior frontal orbital gyri, cuneus and precentral gyrus were negatively correlated with IQ scores. Most of the microstructural changes with associated functional impairment were white matter regions. CONCLUSION: Our study identified vulnerable brain regions with significant white and grey matter microstructural changes that were associated with impaired cognitive function or deficits in physical functioning.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at https://academic.oup.com/neuro-oncology-
dc.relation.ispartofNeuro-Oncology-
dc.relation.ispartofThe 19th International Symposium on Pediatric Neuro-Oncology (ISPNO) 2020-
dc.subjectmagnetic resonance imaging-
dc.subjectradiation therapy-
dc.subjectneurotoxicity syndromes-
dc.subjectdiffusion-
dc.subjectgerm cells-
dc.titleMicrostructural brain changes associated with neurocognitive and functional outcomes of intracranial germ cell tumor (GCT) survivors – a diffusional kurtosis imaging study-
dc.typeConference_Paper-
dc.identifier.emailTso, WYW: wytso@hku.hk-
dc.identifier.emailHui, ESK: edshui@hku.hk-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.emailIp, P: patricip@hku.hk-
dc.identifier.emailFong, DYT: dytfong@hku.hk-
dc.identifier.emailChang, DHF: changd@hku.hk-
dc.identifier.emailYip, KM: kmanyip@hku.hk-
dc.identifier.emailCheuk, DKL: cheukkld@hku.hk-
dc.identifier.emailKhong, PL: plkhong@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.authorityTso, WYW=rp01517-
dc.identifier.authorityHui, ESK=rp01832-
dc.identifier.authorityLee, TMC=rp00564-
dc.identifier.authorityLiu, APY=rp01357-
dc.identifier.authorityIp, P=rp01337-
dc.identifier.authorityFong, DYT=rp00253-
dc.identifier.authorityChang, DHF=rp02272-
dc.identifier.authorityKhong, PL=rp00467-
dc.identifier.authorityChan, GCF=rp00431-
dc.description.natureabstract-
dc.identifier.doi10.1093/neuonc/noaa222.687-
dc.identifier.pmcidPMC7715703-
dc.identifier.hkuros314993-
dc.identifier.volume22-
dc.identifier.issueSuppl. 3-
dc.identifier.spageiii436-
dc.identifier.epageiii436-
dc.publisher.placeUnited States-

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