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Conference Paper: Effects of Bariatric Surgery on Kidney Diseases, Cardiovascular Diseases and Mortality among Patients with Type 2 Diabetes Mellitus

TitleEffects of Bariatric Surgery on Kidney Diseases, Cardiovascular Diseases and Mortality among Patients with Type 2 Diabetes Mellitus
Authors
Issue Date2020
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797
Citation
The 18th Asian Pacific Congress of Nephrology (APCN): Combating CKD in the Asia Pacific: Local Strategies for a Global Problem, Virtual Congress, Hong Kong, 2-4 October 2020. In Nephrology, 2020, v. 25 n. S1, p. 63 How to Cite?
AbstractObjectives: To measure and compare the risks of end‐stage kidney diseases (ESKD), cardiovascular diseases (CVD), all‐cause mortality between obese type 2 diabetes mellitus (T2DM) patients with and without bariatric surgery. Methods: A retrospective population‐based cohort of 1,690 obese T2DM patients who were free of ESKD and CVD were assembled based on 2006‐2017 Hospital Authority database. One‐to‐five propensity‐score matching was used to balance baseline covariates between patients in bariatric surgery and control groups. Incidence rates (IR) of stage 4/5 chronic kidney diseases, ESKD, CVD and all‐cause mortality events for two groups were calculated. Hazard ratios (HR) for stage 4/5 chronic kidney diseases, ESKD, CVD events were assessed using Cox proportional hazard models. Changes in estimated glomerular filtration rate (eGFR), and urine albumin‐creatinine ratio (UACR) were measured up to 60 months. Results: Over a mean follow‐up period of 34 months with 863 person‐years, cumulative incidences of mortality, stage 4/5 chronic kidney diseases, ESKD and CVD for surgical patients were 0, 0.050, 0.017, and 0.036, respectively. Surgical patients had reduced IR of all‐cause mortality, stage 4/5 chronic kidney diseases, ESKD and CVD (IR = 0, 1.784, 0.587 and 1.321 per 100 person‐years, respectively) than control patients (IR = 1.954, 2.028, 0.914 and 2.814 per 100 person‐years, respectively). Surgery group had a significant reduction in risk of CVD events (HR = 0.464, P = 0.015), and no occurrence of mortality events. However, the IR of stage 4/5 chronic kidney diseases and ESKD of the two groups were not significantly different. Surgical patients had significantly higher eGFR within 12 months, and had significantly lower until 48 months. Conclusions: Among obese T2DM patients, bariatric surgery lowered the risk of CVD and mortality, and was beneficial towards the kidney outcomes of eGFR up to 36 months.
DescriptionPoster Presentations - Session 3.4 Clinical CKD - no. 71
Persistent Identifierhttp://hdl.handle.net/10722/287247
ISSN
2019 Impact Factor: 1.749
2015 SCImago Journal Rankings: 0.894

 

DC FieldValueLanguage
dc.contributor.authorWu, T-
dc.contributor.authorWong, CKH-
dc.contributor.authorWong, SKH-
dc.contributor.authorLaw, BTT-
dc.contributor.authorGrieve, E-
dc.contributor.authorWu, O-
dc.contributor.authorLam, CLK-
dc.date.accessioned2020-09-22T02:58:05Z-
dc.date.available2020-09-22T02:58:05Z-
dc.date.issued2020-
dc.identifier.citationThe 18th Asian Pacific Congress of Nephrology (APCN): Combating CKD in the Asia Pacific: Local Strategies for a Global Problem, Virtual Congress, Hong Kong, 2-4 October 2020. In Nephrology, 2020, v. 25 n. S1, p. 63-
dc.identifier.issn1320-5358-
dc.identifier.urihttp://hdl.handle.net/10722/287247-
dc.descriptionPoster Presentations - Session 3.4 Clinical CKD - no. 71-
dc.description.abstractObjectives: To measure and compare the risks of end‐stage kidney diseases (ESKD), cardiovascular diseases (CVD), all‐cause mortality between obese type 2 diabetes mellitus (T2DM) patients with and without bariatric surgery. Methods: A retrospective population‐based cohort of 1,690 obese T2DM patients who were free of ESKD and CVD were assembled based on 2006‐2017 Hospital Authority database. One‐to‐five propensity‐score matching was used to balance baseline covariates between patients in bariatric surgery and control groups. Incidence rates (IR) of stage 4/5 chronic kidney diseases, ESKD, CVD and all‐cause mortality events for two groups were calculated. Hazard ratios (HR) for stage 4/5 chronic kidney diseases, ESKD, CVD events were assessed using Cox proportional hazard models. Changes in estimated glomerular filtration rate (eGFR), and urine albumin‐creatinine ratio (UACR) were measured up to 60 months. Results: Over a mean follow‐up period of 34 months with 863 person‐years, cumulative incidences of mortality, stage 4/5 chronic kidney diseases, ESKD and CVD for surgical patients were 0, 0.050, 0.017, and 0.036, respectively. Surgical patients had reduced IR of all‐cause mortality, stage 4/5 chronic kidney diseases, ESKD and CVD (IR = 0, 1.784, 0.587 and 1.321 per 100 person‐years, respectively) than control patients (IR = 1.954, 2.028, 0.914 and 2.814 per 100 person‐years, respectively). Surgery group had a significant reduction in risk of CVD events (HR = 0.464, P = 0.015), and no occurrence of mortality events. However, the IR of stage 4/5 chronic kidney diseases and ESKD of the two groups were not significantly different. Surgical patients had significantly higher eGFR within 12 months, and had significantly lower until 48 months. Conclusions: Among obese T2DM patients, bariatric surgery lowered the risk of CVD and mortality, and was beneficial towards the kidney outcomes of eGFR up to 36 months.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797-
dc.relation.ispartofNephrology-
dc.relation.ispartof18th Asian Pacific Congress of Nephrology (APCN), Hong Kong-
dc.titleEffects of Bariatric Surgery on Kidney Diseases, Cardiovascular Diseases and Mortality among Patients with Type 2 Diabetes Mellitus-
dc.typeConference_Paper-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.emailLam, CLK: clklam@hku.hk-
dc.identifier.authorityWong, CKH=rp01931-
dc.identifier.authorityLam, CLK=rp00350-
dc.description.natureabstract-
dc.identifier.hkuros314283-
dc.identifier.volume25-
dc.identifier.issueS1-
dc.identifier.spage63-
dc.identifier.epage63-
dc.publisher.placeAustralia-
dc.identifier.partofdoi10.1111/nep.13773-

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